Dialysis apparatus with selective chemical activity

• US 4,192,748 A
• Filed: 11/02/1976
• Issued: 03/11/1980
• Est. Priority Date: 07/05/1973
• Status: Expired due to Term

• Current Assignee: Viktor H. Hyden
• Original Assignee: Viktor H. Hyden
• Inventors: Hyden, Viktor H.
• Primary Examiner(s): Spear, Jr., Frank A.
• Application Number:
  US05/738,328
• Time in Patent Office: 1,225 Days
• Field of Search: 210/22, 210/321 B, 210/494, 210/19, 210/87, 210/96 M, 210/259, 210/255, 210/258, 195/68
• US Class Current: 210/87
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1692 Detection of blood traces in dialysate
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/26 and internal elements which are moving
• CPC Class Codes: A61M 1/3687 Chemical treatment A61M1/3675 takes precedence
• CPC Class Codes: B01D 2313/22 Cooling or heating elements
• CPC Class Codes: B01D 2313/90 Additional auxiliary systems integrated with the module or apparatus
• CPC Class Codes: B01D 61/28 Apparatus therefor
• CPC Class Codes: B01D 61/32 Controlling or regulating
• CPC Class Codes: B01D 63/10 Spiral-wound membrane modules
• CPC Class Codes: B01D 67/0093 Chemical modification
• CPC Class Codes: B01D 69/105 Support pretreatment
• CPC Class Codes: B01D 69/141 Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes

Abstract

A compact dialysis unit having a dialysis membrane forming a partition between a liquid to be dialyzed and a dialysate, at least that surface of the membrane facing the liquid to be dialyzed having a selectively chemically active therapeutic substance fixed thereon and a selectively acting adsorbent in the dialysate circuit. Preferably, the dialysate circuit includes at least one dosimeter and a safety warning system.

Claims

1. A dialysis apparatus comprising a dialysate container, cover means for said dialysate container, a dialysis container mounted on said cover means, said dialysis container having an inlet means and an outlet means, spectrometer means mounted on said cover means, a first fluid circuit means connecting said dialysis container and said dialysate container through said spectrometer means, said first fluid circuit including purification means in said dialysate container, a dialysis membrane for permitting passage of substances with molecular weights of up to between 10,000-15,000 removably mounted in said dialysis container and having a selectively chemically active therapeutic substance insolubilized on at least the surface facing the liquid to be dialyzed, pump means mounted on said cover means for pumping dialysate from said dialysate container to said dialysis container, a second fluid circuit means connecting said pump means with said dialysate container and said dialysis container, and at least one dosimeter means on said dialysate container for metering fluid into said dialysate container.

2. The dialysis apparatus of claim 1 including heating means in said dialysate container.

3. The dialysis apparatus of claim 1 including signal means in combination with said spectrometer means.

4. The dialysis apparatus of claim 1 wherein said membrane is in the form of a helically wound flat hose and said membrane is wound with a distance means.

5. The dialysis apparatus of claim 1 including vibrator means mounted on said dialysate container for intensifying the liquid flow about said membrane.

6. The dialysis apparatus of claim 1 wherein said purification means is an adsorption means.

7. The dialysis apparatus of claim 1 including distribution means for distributing the liquid about said membrane.

8. The dialysis apparatus of claim 1 including further purification means.

9. The dialysis apparatus of claim 1 wherein said chemically active therapeutic substance is selected from the group consisting of enzymers, antibiotics, antigens, antibodies and synthetic adsorbents.

10. A dialysis apparatus comprising a dialysate container, cover means for said dialysate container, a dialysis container mounted on said cover means, said dialysis container having an inlet means and an outlet means, spectrometer means mounted on said cover means, a first fluid circuit means connecting said dialysis container and said dialysate container through said spectrometer means, said first fluid circuit including purification means in said dialysate container, a dialysis membrane for permitting passage of substances with molecular weights up to 10,000-15,000 removably mounted in said dialysis container and having a selectively chemically active therapeutic substance selected from the group consisting of L-aspariginase, urease and an antibiotic insolubilized on at least the surface facing the liquid to be dialyzed for purifying liquid passing through said apparatus, pump means mounted on said cover means for pumping dialysate from said dialysate container to said dialysis container, a second fluid circuit means connecting said pump means with said dialysate container and said dialysis container, and at least one dosimeter means on said dialysate container for metering fluid into said dialysate container.