Orally administrable form of progesterone

• US 4,196,188 A
• Filed: 01/12/1977
• Issued: 04/01/1980
• Est. Priority Date: 11/30/1976
• Status: Expired due to Term

• Current Assignee: Jean-Louis A. Besins
• Original Assignee: Jean-Louis A. Besins
• Inventors: Besins, Jean-Louis A.
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US05/759,277
• Time in Patent Office: 1,175 Days
• Field of Search: 424/37, 424/238, 424/243
• US Class Current: 424/455
• CPC Class Codes: A61K 31/57 substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• CPC Class Codes: A61K 9/14 Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51
• CPC Class Codes: A61K 9/4858 Organic compounds
• CPC Class Codes: C07J 7/002 not substituted in position 16

Abstract

The present invention relates to an orally active pharmaceutical preparation comprised of progesterone, finely ground such that 80% of the progesterone particles are about 1-15 microns in size, suspended in an excipient and contained in capsules. The drug effects increased progestational and contraceptive activity at this particle size.

Claims

1. An effective orally administrable soft gelatin capsule essentially containing micronised particles of recrystallized progesterone at least 80% having a particle size of from 5 to less than about 15 microns, in an oil vehicle, said micronized particles having been micronized in said oil phase.