Control of mastitis and compositions therefor
First Claim
Patent Images
1. An antibacterial composition, comprising:
- (a) a nitroalkanol of the formula ##STR7## wherein R1 is selected from the group consisting of hydrogen, alkyl having 1 to 12 carbon atoms, phenyl alkyl of up to 10 carbon atoms, and, together with R3, R1 and R3 can be the residue of a cycloalkyl ring having 5 to 7 carbon atoms, including the shared carbon atom;
R3, if not part of the said residue, is hydrogen; and
R2 is selected from the group consisting of hydrogen, methyl, ethyl, hydroxymethyl, and bromine;
(b) an aminocarboxylic acid or aminocarboxylate chelating agent having a calcium chelate stability constant of at least about 6;
said chelating agent being combined with said nitroalkanol in an amount sufficient to significantly increase the topical bactericidal effect, in nonalkaline aqueous solution, of said nitroalkanol against Pseudomonas aeruginosa organisms.
0 Assignments
0 Petitions
Accused Products
Abstract
Neutral to mildly acidic externally-applied mastitis control agents based upon antimicrobial nitroalkanols (e.g. 2-bromo-2-nitropropane-1,3-diol) can be made more effective against Pseudomonas aeruginosa through "potentiation" with an aminocarboxylic-type chelating agent. The chelating agent is believed to improve cell-wall permeability, even at a pH well below 7.
-
Citations
20 Claims
-
1. An antibacterial composition, comprising:
-
(a) a nitroalkanol of the formula ##STR7## wherein R1 is selected from the group consisting of hydrogen, alkyl having 1 to 12 carbon atoms, phenyl alkyl of up to 10 carbon atoms, and, together with R3, R1 and R3 can be the residue of a cycloalkyl ring having 5 to 7 carbon atoms, including the shared carbon atom;
R3, if not part of the said residue, is hydrogen; and
R2 is selected from the group consisting of hydrogen, methyl, ethyl, hydroxymethyl, and bromine;(b) an aminocarboxylic acid or aminocarboxylate chelating agent having a calcium chelate stability constant of at least about 6;
said chelating agent being combined with said nitroalkanol in an amount sufficient to significantly increase the topical bactericidal effect, in nonalkaline aqueous solution, of said nitroalkanol against Pseudomonas aeruginosa organisms. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
-
10. An antibacterial composition according to claim 5 wherein the pH of said composition is greater than 4 but less than 6.5 at 23°
- C.
-
11. An antibacterial composition according to claim 10 further comprising a buffering agent to stabilize the pH of said composition at about 5, and an effective amount of an emollient.
-
12. An aqueous teat dip comprising the composition of claim 1, said composition including a thickener for increasing the viscosity of water.
-
-
13. An antibacterial composition, said composition having a pH above 4 and below 6.5 and containing a major amount of water, said composition comprising:
-
(a) 0.05 to 0.5% by weight of 2-bromo-2-nitropropane-1,3-diol; (b) 0.1 to 4% by weight of an ethylenediaminetetraacetate of the formula Hm+ M4-m+ EDTA-4, wherein EDTA-4 represents the ethylenediaminetetraacetate anion, M+ represents a topically acceptable cation, and m represents an integer from 0 to 3; (c) 0.5 to 5% by weight of a compound selected from the group consisting of linear alkylbenzene sulfonic acid and its alkali metal salts; (d) substantially the balance of said composition being an aqueous diluent;
said components (a), (b), and (c) being uniformly distributed through said aqueous diluent. - View Dependent Claims (14, 20)
-
-
15. An aqueous antibacterial composition having a pH of about 5 at 23°
- C., comprising;
2-bromo-2-nitropropane-1,3-diol in an amount of 0.15% by weight; disodium ethylenediaminetetraacetate in an amount of about 1.0 to about 2.0% by weight; C9 to C18 -linear alkylbenzene sulfonate in an amount of from 0.5 to 3.5% by weight; glycerin in an amount of 0.1 to 10% by weight; carboxymethylcellulose in an amount of 1.5% by weight; water in an amount of from about 80 to about 92% by weight; and a citric acid-citrate buffer in an amount sufficient to stabilize said pH. - View Dependent Claims (18)
- C., comprising;
-
16. A method for killing organisms including Pseudomonas aeruginosa on an animal'"'"'s teats comprising the steps of treating the teats of the animal with an aqueous medium containing a nitroalkanol of the formula ##STR8## wherein R1 is selected from the group consisting of hydrogen, alkyl having 1 to 12 carbon atoms, phenyl alkyl of up to 10 carbon atoms, and, together with R3, R1 and R3 can be the residue of a cycloalkyl ring having 5 to 7 carbon atoms, including the shared carbon atom;
- R3, if not the part of the said residue, is hydrogen; and
R2 is selected from the group consisting of hydrogen, methyl, ethyl, hydroxymethyl, and bromine and an aminocarboxylic acid or aminocarboxylate chelating agent having a calcium chelate stability constant of at least about 6, said chelating agent being present in an amount sufficient to significantly increase the topical bactericidal effect of said nitroalkanol against Pseudomonas aeruginosa organisms. - View Dependent Claims (17, 19)
- R3, if not the part of the said residue, is hydrogen; and
Specification