Bladder for liquid dispenser

• US 4,201,207 A
• Filed: 11/26/1976
• Issued: 05/06/1980
• Est. Priority Date: 03/26/1973
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Leeper, Harold M., Buckles, Richard G.
• Primary Examiner(s): Hamrock, William F.
• Application Number:
  US05/745,132
• Time in Patent Office: 1,257 Days
• Field of Search: 526/57, 526/21, 128/214 F, 128/DIG. 12, 222/215, 222/206
• US Class Current: 604/132
• CPC Class Codes: A61M 5/152 pressurised by contraction of elastic reservoirs containers for dispensing contents by contraction of an elastic bag provided therein, in general B65D83/0061
• CPC Class Codes: C08L 9/00 Compositions of homopolymers or copolymers of conjugated diene hydrocarbons
• CPC Class Codes: Y10S 128/12 Pressure infusion

Abstract

An improvement in liquid dispensers, especially those used to infuse liquid drugs into patients, that dispense liquid under pressure from an expansible, elastomer bladder is disclosed. The improvement is that the bladder is made from synthetic vulcanized polyisoprene, especially polyisoprene that has 90% to 98% cis linkages and has been vulcanized with an organic peroxide, such as dicumyl peroxide, at a concentration of 5.5×10^-3 to 7.5×10^-3 moles of peroxide per 100 grams of polyisoprene.

Claims

1. In a dispenser for dispensing a liquid under pressure comprising an expansible elastic bladder for holding the liquid under pressure, the elastic force in whose walls provides the force by which the liquid is dispensed, a flow passage from the bladder, and flow metering means in the flow passage, the improvement wherein the bladder is made of vulcanized, synthetic polyisoprene having a stress relaxation of less than about 10% and a low frequency hysteresis of less than about 10%.

2. The improvement of claim 1 wherein the polyisoprene has from about 85% to about 89% cis linkages.

3. The improvement of claim 1 wherein the polyisoprene has from about 90% to about 98% cis linkages.

4. The improvement of claim 3 wherein the vulcanization has formed cross-links in the polyisoprene, the density of which is about 16 to about 24 cross-links per polyisoprene molecule.

5. The improvement of claim 3 wherein the polyisoprene has been vulcanized with an organic peroxide at a concentration of about 5.5×

10^-3 to about 7.5×

10^-3 moles of peroxide per 100 grams of polyisoprene.

6. The improvement of claim 5 wherein the peroxide is a dicumyl peroxide.

7. The improvement of claim 3 wherein the polyisoprene has been vulcanized with dicumyl peroxide at a concentration of about 6.7×

10^-3 moles of peroxide per 100 grams of polyisoprene.

8. The improvement of claim 1 wherein the dispenser includes a housing and the bladder is contained in the housing in a manner in which it is substantially unrestricted in its deflated and inflated states.

9. In an apparatus for infusing liquid drug into a patient at a controlled rate and under an essentially constant pressure comprising:

an elastomeric, expansible, generally cylindrical bladder for holding the liquid, said bladder having a deflated length that is not less than 5 times the deflated outside diameter and a wall thickness of from 0.01 to 1 times the deflated inside diameter, the elastic force in the wall of the bladder providing said pressure;

a flow passage that communicates with the interior of the bladder and extends to the infusion site; and

a flow control element in the passage for regulating the flow of liquid through the passage, the improvement wherein the bladder is made from synthetic, vulcanized polyisoprene having a stress relaxation of less than about 10% and a low frequency hysteresis of less than about 10%.

10. The improvement of claim 9 wherein the polyisoprene has about 85% to about 98% cis linkages.

11. The improvement of claim 9 wherein the polyisoprene has from about 90% to about 98% cis linkages.

12. The improvement of claim 11 wherein the vulcanization has formed cross-links in the polyisoprene, the density of which is about 16 to about 24 cross-links per polyisoprene molecule.

13. The improvement of claim 11 wherein the polyisoprene has been vulcanized with an organic peroxide at a concentration of about 5.5×

10^-3 to about 7.5×

10^-3 moles of peroxide per 100 grams of polyisoprene.

14. The improvement of claim 13 wherein the peroxide is dicumyl peroxide.

15. The improvement of claim 11 wherein the polyisoprene has been vulcanized with dicumyl peroxide at a concentration of about 6.7×

10^-3 moles of peroxide per 100 grams of polyisoprene.

16. The improvement of claim 9 wherein the apparatus includes a housing that contains the bladder, and the bladder is contained in the housing in a manner in which it is unrestricted in its inflated and deflated states.

17. The improvement of claim 9 wherein the bladder has a deflated length that is 5 to 20 times its deflated inside diameter and a wall thickness of from 0.1 to 0.5 times its deflated inside diameter.