Veterinary ocular ring device for sustained drug release

• US 4,201,210 A
• Filed: 11/28/1977
• Issued: 05/06/1980
• Est. Priority Date: 06/22/1976
• Status: Expired due to Term

• Current Assignee: United States Department Of Agriculture
• Original Assignee: United States Department Of Agriculture
• Inventors: Hughes, David E., Pugh, George W. Jr.
• Primary Examiner(s): Yasko, John D.
• Application Number:
  US05/855,495
• Time in Patent Office: 890 Days
• Field of Search: 128/260, 424/14, 424/22, 424/28
• US Class Current: 424/428
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants

Abstract

A novel ring-shaped device inserted into the conjunctival sac of an animal eye exhibits potential for prolonged release of therapeutic drugs to the eye region. Its prolonged retention properties render it suitable for use in the extended treatment of obstinate ocular infections, such as infectious bovine keratoconjunctivitis in cattle.

Claims

1. A method for releasing over a prolonged period of time a therapeutic agent into the region of an eye of an animal comprising inserting into the conjunctival sac of said eye a substantially ring-shaped device releasably containing said therapeutic agent, and releasing said agent into said eye region over a prolonged period.

2. The method of claim 1, wherein said inserted device is sufficiently pliable in all dimensions to permit conformation to the shape of said conjunctival sac.

3. The method of claim 1, wherein said inserted device surrounds the globe of the eye.

4. The method of claim 1, wherein said animal is a bovine.

5. The method of claim 1, wherein said therapeutic agent is an antibiotic.

6. The method of claim 1, wherein said ring-shaped device comprises an erodable matrix having said therapeutic agent releasably contained therein, and said releasing step is effected by the degradation of said matrix.

7. The method of claim 1, wherein said therapeutic agent is contained within a reservoir internal to said ring-shaped device, and said agent is released over a prolonged period through a plurality of holes from said reservoir to said eye region.

8. An apparatus adapted for insertion into the conjunctival sac of the eye of an animal surrounding the globe of said eye comprising a ring-shaped member having means associated therewith for the prolonged release of a therapeutic agent into the region of said eye.

9. The apparatus defined by claim 8 wherein said prolonged release means comprises an erodable matrix.

10. The apparatus defined by claim 8 wherein said prolonged release means comprises an internal reservoir cavity in said ring-shaped member for holding said therapeutic agent and a plurality of holes communicating with said cavity and the exterior of said member for releasing said agent into said eye region.

11. The apparatus defined by claim 10 further comprising a hollow tubular appendage affixed to said member and in communication with said internal cavity adapted for filling said cavity with said agent.

12. A method for releasing over a prolonged period of time a therapeutic agent into the region of an eye of an animal having an eye structure inclusive of a nictitating membrane, comprising inserting into the conjunctival sac of said eye, surrounding the globe of said eye, and positioning onto the outer surface of said nictitating membrane a substantially ring-shaped device releasably containing said therapeutic agent, and releasing said agent into said eye region over a prolonged period.

13. An apparatus adapted for insertion into the conjunctival sac of the eye of an animal and further adapted for surrounding the globe of said eye and for positioning onto the outer surface of the nictitating membrane comprising a ring-shaped member having means associated therewith for the prolonged release of a therapeutic agent into the region of said eye.

14. In a non-corneal, drug dispensing ocular insert comprising a flexible body containing a drug for application to the eyeball to dispense said drug to the eye over a prolonged period of time, the improvement comprising a means for permitting facile insertion into and comfortable retention within the eye, and concomitantly preventing the expulsion of the insert therefrom, wherein said flexible body comprises an annular ring that is sized relative to the eye so it can be placed about the eyeball and in contact therewith, completely posterior to the sulcus sclerae and within the upper and lower cul-de-sacs, the width of the ring being such that the ring is virtually invisible in the palpebral fissure when the eyelids are open.

15. The ocular insert as defined by claim 14, containing an ophthalmic drug.

16. The ocular insert as defined in claim 14, wherein said width is about 1 to 12 mm.