Method and apparatus for measurement and registration of the aggregation rate of particles suspended in a liquid
First Claim
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1. A method for measuring the rate of aggregation of particles suspended in a liquid and in particular for measuring the rate of aggregation of red blood corpuscles in the blood, comprising the steps of:
- introducing a blood sample into the interior of a disc-shaped cuvette having opposed side walls, the latter being disposed in the path of a light beam of a light source;
subjecting the blood sample contained within said cuvette to a shear movement around an axis of shear movement to prevent substantial sedimentation of the formed aggregates, said shear movement axis being substantially parallel and substantially coincident to said light beam path; and
measuring the change in intensity of the light beam which impinges on the blood sample within said cuvette.
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Abstract
A method for the measurement of the aggregation rate of particles suspended in a liquid, particularly of red blood corpuscles in the blood by measuring the intensity of a light beam impinging on the blood sample and leaving the sample again, wherein said blood sample is arranged in a disc cuvette in the horizontal beam path of a light source and is subjected to a shear movement during the course of the measurement of the light beam leaving the sample, and an apparatus for carrying out this measurement.
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32 Claims
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1. A method for measuring the rate of aggregation of particles suspended in a liquid and in particular for measuring the rate of aggregation of red blood corpuscles in the blood, comprising the steps of:
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introducing a blood sample into the interior of a disc-shaped cuvette having opposed side walls, the latter being disposed in the path of a light beam of a light source; subjecting the blood sample contained within said cuvette to a shear movement around an axis of shear movement to prevent substantial sedimentation of the formed aggregates, said shear movement axis being substantially parallel and substantially coincident to said light beam path; and measuring the change in intensity of the light beam which impinges on the blood sample within said cuvette. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 32)
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12. Apparatus for measuring the rate of aggregation of particles suspended in a liquid and in particular for measuring the rate of aggregation of red blood corpuscles in the blood, comprising:
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light source means for projecting a light beam along a light beam path; a disc-shaped cuvette having opposed side walls adapted to contain a blood sample, said cuvette being mounted in said light beam path for rotation about an axis of rotation which substantially concides with said light beam path; means provided within said cuvette for subjecting the blood sample to a shear movement around an axis of shear movement upon rotation of said cuvette, said shear movement axis being substantially parallel to said light beam path; and means for measuring the change in intensity of the light beam which impinges on the blood sample within said cuvette. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 30, 31)
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20. An apparatus for measuring the rate of aggregation of particles suspended in a liquid and in particular for measuring the rate of aggregation of red blood corpuscles in the blood, comprising:
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light source means for projecting a light beam along a light beam path; a disc-shaped cuvette mounted in said light beam path having opposed side walls adapted to contain a blood sample; a rotatable body disposed within said cuvette adapted to rotate in the plane of said cuvette around an axis substantially parallel to said light beam path to subject the blood sample to a shear movement upon rotation of said body; magnetic means located outside of said cuvette for magnetically coupling to and rotating said rotable body; and means for measuring the change in intensity of the light beam which impinges on the blood sample within said cuvette. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification