Limb blood flowmeter

• US 4,204,545 A
• Filed: 04/21/1978
• Issued: 05/27/1980
• Est. Priority Date: 09/07/1977
• Status: Expired due to Term

• Current Assignee: Asahi Medical Co. Ltd. (Asahi Kasei Corporation)
• Original Assignee: Asahi Medical Co. Ltd. (Asahi Kasei Corporation)
• Inventors: Yamakoshi, Kenichi
• Primary Examiner(s): Michell, Robert W.
• Assistant Examiner(s): Jaworski, Francis J.
• Application Number:
  US05/898,561
• Time in Patent Office: 767 Days
• Field of Search: 128/2.05 V, 128/2.1 Z, 128/2.05 F, 128/680, 128/689, 128/691, 128/693, 128/734, 73/194 R
• US Class Current: 600/506
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/0235 Valves specially adapted therefor
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: G01R 27/02 Measuring real or complex resistance, reactance, impedance, or other two-pole characteristics derived therefrom, e.g. time constant by measuring phase angle only G01R25/00

Abstract

A human limb to be examined is pressurized on the side of the heart to occlude the venous return alone for the measurement of admittance of the limb, and the measured initial admittance is retained and compared with subsequently measured admittance to detect a difference ΔY therebetween. The blood resistivity ρ, the length L of the limb segment to be examined and its tissue volume V_O are respectively set, and ρL² ΔY/V_O is computated. The initial gradient of the computation result to time is indicative of the blood flow rate in the limb being examined.

Claims

1. A limb blood flowmeter comprising:

occluding pressure means for applying pressure to a limb to be examined on the side of the heart to occlude only the venous return;

admittance measuring means for measuring the admittance of the limb;

means for holding an initial admittance of the limb at the start of measurement;

a subtractor for deriving an admittance change Δ

Y from the difference tetween the initial admittance and an admittance measured subsequently and operative to produce an electrical signal corresponding to Δ

Y;

means for setting the value of the blood resistivity ρ

of the limb and operative to produce a corresponding electrical signal;

means for setting the value of the length L of the region of the limb to be examined and operative to produce a corresponding electrical signal;

means for setting the value of the tissue volume V_O of the region to be examined and operative to produce a corresponding electrical signal;

a calculator responsive to said electrical signals for calculating ρ

L² Δ

Y/V_O based on the output Δ

Y from the subtractor and the blood resistivity ρ

, the length L and the volume V_O set in the setting means; and

a controller for controlling the occluding pressure means and the holding of the initial admittance of the limb.

2. A limb blood flowmeter according to claim 1, wherein the admittance measuring means is composed of impedance measuring means for measuring the impedance of the limb and a divider for obtaining the reciprocal of the measured impedance.

3. A limb blood flowmeter according to claim 2, wherein the impedance measuring means is composed of first and second electrodes disposed on the limb at spaced positions in the longitudinal direction of the limb, AC current supply means for applying a substantially constant AC current across the first and second electrodes, third and fourth electrodes disposed on the limb on the inside of the arrangement of the first and second electrodes, and impedance signal detecting means for obtaining a voltage corresponding to the impedance between the third and fourth electrodes.

4. A limb blood flowmeter according to claim 3, wherein the AC current supply means is composed of an AC current generator, an isolating transformer for applying the AC current from the AC current generator across the first and second electrodes, a current detecting resistor connected in series with the secondary side of the isolating transformer to provide a voltage proportional to the magnitude of the applied AC current, a transformer having its primary side connected to both ends of the current detecting resistor, and a comparator for comparing a voltage produced at the secondary side of the transformer with a reference voltage to control the AC current generator by negative feedback to make constant the current flowing across the first and second electrodes.

5. A limb blood flowmeter according to claim 3, wherein the impedance signal detecting means is composed of first and second coupling capacitors respectively connected at one end to the third and fourth electrodes, a differential amplifier connected between the other ends of the first and second coupling capacitors, a transformer connected to the output side of the differential amplifier, and an AC-DC converter connected to the secondary side of the transformer.

6. A limb blood flowmeter according to claim 1, wherein the calculator is composed of a part for calculating ρ

L² /V_O and a part for multiplying the calculated result by Δ

Y.

7. A limb blood flowmeter according to claim 1, wherein the occluding pressure means is composed of a band-like bag wrapped around the limb on the side of the heart and supplied with pressurized air to be inflated, and a pressure control part for controlling the supply of the pressurized air.

8. A limb blood flowmeter according to claim 7, wherein the pressure control part is composed of a compressed air source, means for converting a pressure control electrical signal from the controller to a pneumatic signal, and a three-way valve controlled by the converted pneumatic signal to switchingly connect the band-like bag to the compressed air source and the outside air.

9. A limb blood flowmeter according to claim 1, which further includes a recorder supplied with the output from the calculator to record it.

10. A limb blood flowmeter according to claim 1, which further includes a circuit for sampling the output from the calculator T₅ seconds after the occlusion of the venous return, a circuit for multiplying the sampled value by 60/T₅, and a display for displaying the multiplied result.

11. A limb blood flowmeter according to claim 1, which further includes means for picking up AC components of the measured admittance from the admittance measuring means, means for counting pulses of the AC components every unit time, and means for displaying the counted result as the heart rate.

12. A limb blood flowmeter according to claim 1, wherein the occluding pressure means is so constructed as to provide a pressure for also occluding the arterial inflow in the limb, and which further includes means for detecting the magnitude of the arterial inflow in the limb, means for displaying, as the systolic blood pressure, the pressure of the occluding pressure means upon stoppage or starting of the arterial inflow by pressure increasing or decreasing control of the occluding pressure means, and means for displaying, as the diastolic blood pressure, the pressure of the occluding pressure means at the moment of the amplitude of the arterial inflow becoming constant when the occluding pressure means is switched from its pressure increasing state to its pressure decreasing state.

13. A limb blood flow rate measuring method comprising the steps of:

appling pressure to a limb to be examined on the side of the heart to occlude only the venous return;

measuring the admittance of the limb and holding the initial admittance of the limb at the start of measurement;

measuring the admittance of the limb after holding of the initial admittance and subtracting the measured value from the initial admittance to obtain an admittance change Δ

Y;

calculating Δ

V=ρ

L² Δ

Y/V_O based on the blood resistivity ρ

of the limb to be measured and the length L and the tissue volume V_O of the region of the limb to be examined; and

obtaining the limb blood flow rate from an initial gradient of the calculated Δ

V.