System for controlling the flow of intravenous fluids to a patient

• US 4,207,871 A
• Filed: 06/07/1978
• Issued: 06/17/1980
• Est. Priority Date: 06/07/1978
• Status: Expired due to Term

• Current Assignee: ALARIS Medical Systems, Inc. (Becton, Dickinson & Co)
• Original Assignee: IMED Corp (Becton, Dickinson & Co)
• Inventors: Jenkins, Jon A.
• Primary Examiner(s): Artis, Henry K.
• Application Number:
  US05/913,294
• Time in Patent Office: 741 Days
• Field of Search: 128/214 R, 128/214 C, 128/214 E, 128/214 F, 128/260, 128/227
• US Class Current: 604/65
• CPC Class Codes: A61M 5/16809 by repeated filling and emptying of an intermediate volume pressure infusion using positive displacement pumps A61M5/142

Abstract

A controller provides precisely regulated flow of intravenous fluid on a gravitational basis to a patient. The controller includes a storage chamber with first and second compartments and a diaphragm separating the compartments and movable in the chamber to vary the volumes of the first and second compartments. The storage chamber may be disposed in a replaceable cassette. Control means provide at first times for the introduction of fluid from the source to the first compartment and the passage of fluid from the second compartment to the patient. The control means provide at other times for the introduction of fluid from the source to the second compartment and the passage of fluid from the first compartment to the patient. The control means may also be included at least partially in the cassette. Means operate upon the control means, upon the movement of the diaphragm to a particular position in the second compartment, to obtain the introduction of fluid from the source to the first compartment and the passage of fluid from the second compartment to the patient. Such means operate on the control means, upon the movement of the diaphragm to a particular position in the first compartment, to obtain the introduction of fluid from the source to the second compartment and the passage of fluid from the first compartment to the patient. The control means also control at each instant the rate at which fluid flows from each of the compartments to the patient by comparing at such instant desired and actual rates of fluid flow and by providing adjustments in accordance with such comparison.

Claims

1. In combination in a system for providing a controlled introduction of fluid from a source to a patient,

first means for storing the fluid, the first means including first and second compartments and a diaphragm separating the compartments and movable in the first means to vary the volumes of the first and second compartments,

second means operatively coupled to the first and second compartments for providing a first times for the introduction of fluid from the source to the first compartment and the passage of fluid from the second compartment to the patient and at other times for the introduction of fluid from the source to the second compartment and the passage of fluid from the first compartment to the patient, and

third means responsive to the movement of the diaphragm to a particular position in the second compartment for operating on the second means to obtaining the introduction of fluid from the source to the first compartment and the passage of fluid from the second compartment to the patient and responsive to the movement of the diaphragm to a particular position in the first compartment for operating on the second means to obtain the introduction of fluid from the source to the second compartment and the passage of fluid from the first compartment to the patient.

2. The combination set forth in claim 1, including,

a conduit extending from the second means to the patient,

adjustable means operatively coupled to the second means for controlling the flow of fluid through the conduit,

means for providing a desired rate of flow of the fluid to the patient,

means responsive to the movements of the diaphragm for providing an indication of the actual rate of flow to the patient, and

means responsive to the desired and actual rates of flow of the fluid to the patient for adjusting the adjustable means to control the actual rate of flow to the patient in accordance with any differences between the actual and desired rates.

3. The combination set forth in claim 2, including,

transducer means responsive to the movement of the diaphragm for producing a variable impedance in accordance with such movement,

means responsive to the variable impedance provided by the transducer means for producing signals having a variable frequency in accordance with such impedance variations, and

means responsive to the variable frequency of the signals for indicating the position of the diaphragm at each instant and the rate of flow of the fluid to the patient.

4. In combination in a system for providing a controlled introduction of fluid from a source to a patient,

first and second storage means,

first means operatively coupled to the first and second storage means and having first and second states of operation and operative in the first state for providing for a flow of fluid from the source to the first storage means and a simultaneous flow of fluid from the second storage means to the patient and operative in the second state for providing for a flow of fluid from the source to the second storage means and a simultaneous flow of fluid from the first storage means to the patient, and

second means operatively coupled to the first means and responsive to cumulative flows of fluid from each of the first and second storage means for alternately producing an operation of the first means in the first and second states.

5. The combination set forth in claim 4 wherein

the second means is responsive, in the first state of operation of the first means, to the flow of a particular amount of fluid to the first storage means and from the second storage means to produce an operation of the first means in the second state and is responsive, in the second state of operation of the first means, to the flow of a particular amount of fluid to the second storage means and from the first storage means to produce an operation of the first means in the first state.

6. The combination set forth in claim 5, including,

the first and second storage means being defined by a chamber and a diaphragm movable in the chamber to increase the volume of one of the storage means and correspondingly decrease the volume of the other storage means, and

the second means being responsive to each movement of the diaphragm to a particular position in the first compartment to initiate an operation of the first means in the second state and being responsive to each movement of the diaphragm to a particular position in the second compartment to initiate an operation of the first means in the first state.

7. The combination set forth in claim 5, including,

control means adjustable to control the rate at which fluid passes from the first means to the patient, and

third means responsive to the rate of flow of fluid to the patient for adjusting the control means to maintain the flow of the fluid to the patient at a particular rate.

8. The combination set forth in claim 7, including,

the first means including an output line extending to the patient and

the control means including an adjustable clamp for pinching the line to control the rate at which fluid flows through the output line to the patient, and

the third means including

means adjustable to provide a desired rate at which fluid flows to the patient,

means responsive to the flow of fluid to the patient for indicating the rate of such flow,

means responsive to the indications of the desired and actual rates of fluid flow for comparing such indications to produce an error signal in accordance with any differences in such indications, and

means reponsive to the error signal for adjusting the clamping action of the clamp on the output line to minimize the error signal.

9. In combination in a system for providing a controlled introduction of fluid from a source to a patient,

first means for storing the fluid, the storing means including a movable diaphragm for dividing the storing means into first and second compartments,

second means for providing for an introduction of fluid from the source to one of the compartments and for providing for the passage of fluid from the other compartment to the patient,

first adjustable means for controlling the rate at which fluid passes from the second means to the patient,

second adjustable means for providing a desired rate at which fluid is to pass to the patient,

third means operatively coupled to the second means for indicating the rate at which fluid is actually flowing to the patient,

fourth means operatively coupled to the second adjustable means and to the third means and responsive to the indications of the desired and actual rates of fluid flow for producing an error signal in accordance with any differences in such signals,

fifth means reponsive to the error signals for producing adjustments in the first adjustable means to minimize such error signals, and

sixth means operatively coupled to the second means and responsive to the flow of fluid to the patient for providing at first times for the introduction of fluid into the first compartment and the passage of fluid from the second compartment and, at second times alternating with the first times, for the introduction of fluid into the second compartment and the passage of fluid from the first compartment.

10. The combination set forth in claim 9, includng,

the first means including an output line to the patient,

the first adjustable means including a clamp adjustable on the output line to control the rate at which fluid flows through the output line, and

the fifth means including means for controlling the clamping of the first adjustable means on the output line.

11. The combination set forth in claim 9, including,

the first means constituting a replaceable cassette and the storage means constituting a chamber in the cassette and the movable diaphragm extending across the chamber to divide the chamber into first and second compartments and the diaphragm being resilient for movement across the chamber to increase the volume of one of the compartments and correspondingly decrease the volume of the other compartment.

12. The combination set forth in claim 11, including,

the sixth means including valve means disposed in the cassette and operative in first and second relationships and operative in the first relationship to provide for the introduction of fluid into the first compartment and the passage of fluid from the second compartment and operative in the second relationship to provide for the introduction of fluid into the second compartment and the passage of fluid from the first compartment.

13. The combination set forth in claim 12, including,

the sixth means including a first pair of valves each having first and second operative relationships, a first one of the valves in the first pair providing in the first operative relationship for the introduction of fluid into the first compartment from the source and preventing in the second operative relationship the introduction of fluid into the first compartment from the source, the other valve in the first pair providing in the first operative relationship for the passage of fluid from the second compartment to the patient and preventing in the second operative relationship the passage of fluid from the second compartment to the source,

the sixth means including a second pair of valves each having first and second operative relationships, a first one of the valves in the second pair providing in the first operative relationship for the introduction of fluid into the second compartment from the source and preventing in the second operative relationship the introduction of fluid into the second compartment from the source, the other valve in the second pair providing in the first operative relationship for the passage of fluid from the first compartment to the patient and preventing in the second operative relationship the passage of fluid from the first compartment to the source, and

the sixth means being responsive to the movement of the diaphragm to a particular position in a direction to reduce the size of the first compartment for producing an operation of the valves in the first pair in the first relationship and an operation of the valves in the second pair in the second relationship and being responsive to the movement of the diaphragm to a position in a direction to reduce the size of the second compartment for producing an operation of the valves in the second pair in the first relationship and an operation of the valves in the first pair in the second relationship.

14. In combination in a system for providing a controlled introduction of fluid from a source to a patient,

storage means constructed to provide a flow into the storage means from first and second operative directions and to provide a flow from the storage means from first and second opposite directions,

first means for providing for an introduction of fluid from the source into the storage means in the first and second opposite directions,

second means for providing for a passage of fluid from the storage means to the patient in the first and second opposite directions,

valve means operatively coupled to the storage means and having first and second operative relationships and operative in the first relationship to provide for a flow of fluid into the storage means only in the first direction and a passage of fluid from the storage means only in the second direction and operative in the second relationship to provide for a flow of fluid into the storage means only in the second direction and a passage of fluid from the storage means only in the first direction, and

means responsive to the flows of particular amounts of the fluid into and out of the storage means in one of the first and second operative relationships for reversing the operation of the valve means to the other one of the first and second operative relationships.

15. The combination set forth in claim 14, including,

the storage means being constructed to define first and second compartments and the flow in the first and second directions into the storage means respectively being into the first and second compartments and the flow in the second and second directions from the storage means being respectively from the first and second compartments.

16. The combination set forth in claim 15, including,

the valve means being operative in the first relationship to provide for the flow of fluid into the first compartment and out of the second compartment and being operative in the second relationship to provide for the flow into the second compartment and out of the first compartment.

17. The combination set forth in claim 16, including,

the reversing means being operatively associated with the storage means for providing for a flow at each instant of the same amount of fluid into one of the first and second compartments and from the other one of the first and second compartments.

18. The combination set forth in claim 17, including,

the reversing means also being operative to reverse the operative of the valve means from one of the first and second relationships to the other one of the first and second relationships upon each flow of a particular amount of fluid into one of the compartments and out of the other one of the compartments.

19. The combination set forth in claim 18, including,

the first providing means including an input line and a first pair of branch lines respectively extending from the input line to the first and second compartments,

the second providing means including a second pair of branch lines respectively extending from the first and second compartments and an output line communicating with the second pair of branch lines.

20. The combination set forth in claim 19, including,

the valve means including a plurality of valves each disposed in an individual one of the branch lines in the first and second pairs and operative to control the flow of fluid through the associated one of the branch lines in accordance with the operation of the valve means in the first and second relationships.

21. In combination in a system for providing a controlled introduction of fluid from a source to a patient,

means for providing an indication of a desired rate for introducing fluid into a patient,

means responsive to the flow of fluid for providing an indication of the rate at which fluid is flowing into the patient,

means responsive to the indications of the desired and actual rates of flow for producing an error signal having characteristics representing any differences in such indications,

means including a replaceable cassette for providing a reservoir for the controlled storage of fluid flowing from the source and for the controlled flow of the stored fluid to the patient,

an output line extending from the replaceable cassette for introducing fluid from the reservoir to the patient,

an input line extending to the replaceable cassette for introducing fluid to the reservoir from the source, and

means associated with the output line and responsive to the error signal for adjustably controlling the rate at which fluid flows from the reservoir through the output line to the patient in accordance with the characteristics of the error signal.

22. The combination set forth in claim 21 wherein

the reservoir has first and second ends and the means including the cassette includes means for providing for the introduction of fluid to the reservoir at a particular one of the first and second ends and for providing for the passage of fluid from the reservoir at the other one of the first and second ends and for obtaining a reversal of the particular one of the first and second ends for providing for the introduction of fluid into the reservoir and a reversal of the other one of the first and second ends for the passage of fluid from the reservoir to the patient.

23. The combination set forth in claim 22 wherein

the means including the cassette includes valve means having first and second operative relationships and operative in the first relationship to provide for an introduction of fluid to the first end of the reservoir and a passage of fluid from the second end of the reservoir and operative in the second relationship to provide for an introduction of fluid to the second end of the reservoir and a passage of fluid from the first end of the reservoir.

24. The combination set forth in claim 23, including,

the means including the cassette including means for providing for a reversal of the valve means between the first and second operative relationships every time that a particular amount of fluid flows from the reservoir to the patient.

25. In combination in a systen for providing a controlled introduction of fluid from a source to a patient,

means for providing an indication of a desired rate for introducing fluid to a patient,

means responsive to the flow of fluid for providing an indication of the rate at which fluid is flowing to the patient,

means responsive to the indications of the desired and actual rate of flow for producing an error signal having characteristics representing any differences in such indications,

means for providing a reservoir for the storage of fluid and for the controlled flow of fluid from the source and for the controlled flow of fluid to the patient and for the flow of fluid to the reservoir at the same rate as the flow of fluid from the reservoir,

an input line for introducing fluid from the source to the reservoir,

an output line for introducing fluid from the reservoir to the patient, and

means associated with the output line and responsive to the error signal for adjustably controlling the rate at which fluid flows from the reservoir through the output line to the patient.

26. The combination set forth in claim 25, including,

resilient means being disposed in the reservoir for dividing the reservoir into first and second compartments,

means operatively associated with the reservoir for providing for the introduction of fluid into one of the compartments and the simultaneous flow of fluid from the other compartment, and

means operatively associated with the last mentioned means and responsive to particular cumulative increases in the volume of fluid flowing to a patient to reverse the particular one of the compartments receiving the flow of fluid from the source and the other one of the compartments providing for the flow of fluid to the patient.

27. The combination set forth in claim 26, including,

each of the first and second compartments having an individual conduit extending from the input line and having an individual conduit extending to the output line and the reversing means including a plurality of valves each disposed in an individual one of the lines and having first and second states of operation and operative in the first state to provide for a flow of flow through the associated conduit and operative in the second state to prevent the flow of fluid through the associated conduit.

28. The combination set forth in claim 27, including,

the valves being paired to provide for an operation at each instant of the valves in one pair in the first state and the operation of the valves in the other pair in the second state and one of the valves in each pair being associated with an individual one of the conduits extending from the input line and the other valve in each pair being associated with an individual one of the conduits extending to the output line.

29. In combination in a system for providing a controlled introduction of fluid from a source to a patient,

means for providing an indication of a desired rate for introducing fluid to a patient,

means responsive to the flow of fluid for providing an indication of the rate at which fluid is flowing to the patient,

means responsive to the indications of the desired and actual rates of flow for producing an error signal having characteristics representing any differences in such indications,

means for providing a reservoir for the fluid,

means for providing for a flow of fluid from the reservoir to the patient,

means operatively coupled to the last-mentioned means and responsive to the error signal for adjusting the rate of the flow of fluid from the reservoir to the patient in accordance with the characteristics of such error signal, and

means for providing for the introduction of fluid from the source to the reservoir to replenish the fluid flowing from the reservoir to the patient.

30. The combination set forth in claim 29 wherein

the means for providing for the flow of fluid to the patient includes an output line having an orifice for the flow of fluid and the means for adjusting the rate of such fluid flow includes an adjustable clamp for controlling the size of the orifice in the output line.

31. In combination in a system for providing a controlled introduction of fluid from a source to a patient,

means for providing a first signal representing at each instant a desired flow of the fluid from the source to the patient,

means responsive to the first signal for integrating the signal to provide an indication of the cumulative amount of fluid flow desired at each instant,

conduit means for providing for a controlled flow of fluid from the source to the patient,

means for providing a second signal representing at each instant the actual flow of fluid from the source to the patient at that instant,

means responsive to the second signal for integrating the second signal to provide an indication of the cumulative amount of fluid actually flowing to the patient,

means responsive to the indications representing the cumulative values of the actual and desired flows of fluid to the patient for producing an error signal representative of such differences, and

means responsive to the error signal for adjusting the conduit means in a direction for varying the fluid flow through the conduit means to minimize the error signal.

32. The combination set forth in claim 31, including,

means responsive to the error signal for differentiating the error signal to indicate rate of change in the error signal, and

means for summing the error signal and the differentiated error signal to produce a composite signal,

the adjusting means for the conduit means being responsive to the composite signal to adjust the flow of fluid through the conduit means in a direction to minimize the composite signal.

33. The combination set forth in claim 31 wherein

the conduit means constitutes a plastic tube and wherein the adjustable means pinches the tube in accordance with the characteristics of the error signal.

34. The combination set forth in claim 32 wherein

the conduit means constitutes a plastic tube and wherein the adjustable means pinches the tube in accordance with the characteristics of the composite signal and wherein the error signal means constitutes a comparator for comparing the cumulative values of the actual and desired flows of fluid to the patient for producing the composite signal.

35. In combination in a system for providing a controlled introduction of fluid from a source to a patient,

means for providing a first signal representing at each instant a desired flow of the fluid from the source to the patient,

conduit means for providing for a flow of fluid from the source to the patient,

means operatively coupled to the conduit means for adjustably pinching the conduit means to control the rate at which the fluid flows from the source to the patient,

means operatively coupled to the conduit means for providing a second signal representing at each instant the actual flow of fluid from the source to the patient,

comparator means responsive to the first and second signals for comparing these signals to produce an error signal representing any differences between the first and second signals, and

means responsive to the error signal for adjusting the pinching of the conduit means in a direction to minimize the error signal.

36. The combination set forth in claim 35 wherein

the conduit means constitutes a plastic tube and the adjusting means pinches the tube to control the orifice in the tube.