Method and apparatus for the diagnosis of tissue samples
First Claim
1. Apparatus for the histological diagnosis of tissue samples, utilizing solid tissues samples particularly for effecting a quick diagnosis of tumors, comprising:
- a pair of planar plates transparent to ultraviolet light for pressing therebetween a solid tissue sample to be diagnosed;
a source of ultraviolet light arranged to direct said light through said tissue sample pressed between said glass plates;
convergent lens means located between said tissue sample and said light source;
monochromator means having an exit slit projected onto said sample by said lens means;
goniometer means having a movable graduated circle and defining a center located in said sample;
ultraviolet light detector means mounted on said movable graduated circle of said goniometer means arranged to receive ultraviolet radiation emerging from said tissue sample;
time-interval integrating digital voltmeter means receiving measuring signals from said detector; and
computer means connected to said digital voltmeter means;
said apparatus operating to analyze ultraviolet radiation emerging from said sample to determine a diagnostic parameter of said sample.
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Abstract
A diagnostic technique to histologically detect malignancy and other tissue properties is performed by pressing a solid tissue sample between a pair of planar parallel plates transparent to ultraviolet light to a fraction of the original thickness of the sample and by subsequently passing focused ultraviolet light therethrough. The ultraviolet light is passed transversely to the planar glass plates and the emerging angularly distributed light is analyzed to determine a dignity parameter of the sample containing diagnostic information. The dignity parameter is a unique, monotonous and continuous function of the relation of the forward scatter coefficient to the extinction coefficient of the compact portions of the tissue of the sample.
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Citations
13 Claims
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1. Apparatus for the histological diagnosis of tissue samples, utilizing solid tissues samples particularly for effecting a quick diagnosis of tumors, comprising:
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a pair of planar plates transparent to ultraviolet light for pressing therebetween a solid tissue sample to be diagnosed; a source of ultraviolet light arranged to direct said light through said tissue sample pressed between said glass plates; convergent lens means located between said tissue sample and said light source; monochromator means having an exit slit projected onto said sample by said lens means; goniometer means having a movable graduated circle and defining a center located in said sample; ultraviolet light detector means mounted on said movable graduated circle of said goniometer means arranged to receive ultraviolet radiation emerging from said tissue sample; time-interval integrating digital voltmeter means receiving measuring signals from said detector; and computer means connected to said digital voltmeter means; said apparatus operating to analyze ultraviolet radiation emerging from said sample to determine a diagnostic parameter of said sample. - View Dependent Claims (2, 3, 4, 5, 9, 11)
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6. A method for the histological diagnosis of tissue samples, particularly for effecting quick diagnosis of tumors, comprising the steps of:
- placing a solid tissue sample between a pair of planar members transparent to ultraviolet light;
pressing said sample between said members to a thickness substantially greater than the thickness of a single cell of said sample;
passing focused ultraviolet light through the pressed sample in a direction transversely to said planar members;
analyzing the angular distribution of ultraviolet radiation emerging from said sample; and
determining a diagnostic parameter of said sample from said analysis of said angular distribution of said emerging ultraviolet radiation. - View Dependent Claims (7, 8, 10, 12, 13)
- placing a solid tissue sample between a pair of planar members transparent to ultraviolet light;
Specification