Device using hydrophilic polymer for delivering drug to biological environment

• US 4,207,893 A
• Filed: 12/26/1978
• Issued: 06/17/1980
• Est. Priority Date: 08/29/1977
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Michaels, Alan S.
• Primary Examiner(s): Michell, Robert W.
• Assistant Examiner(s): Rosenbaum, C. F.
• Application Number:
  US05/972,958
• Time in Patent Office: 539 Days
• Field of Search: 128/213 R, 128/232, 128/260, 128/261-262, 128/271, 424/14, 424/25, 424/27
• US Class Current: 604/892.1
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A self-powered device for delivering drug is disclosed. The device comprises (1) a substantially rigid housing, (2) a collapsible container storing a drug and having a passageway for delivering the drug in the housing, and (3) an expandable laminate positioned between the housing and the container. The laminate comprises (a) a lamina formed of an absorbent material laminated to (b) a lamina placed adjacent to the container and formed of a swellable hydrophilic polymer. In operation, when the device is in a biological environment, fluid from the environment is imbibed by the laminate into the housing causing the laminate to expand and exert pressure on the container, thereby collapsing the container and concomitantly pumping drug through the passageway from the device at a correspondingly controlled rate over a prolonged period of time.

Claims

1. A Drug delivery device comprising:

(a) a drug

(b) a housing having a shape-retaining wall defining an internal space and an opening connecting the space with the exterior of the device, said housing formed of a member selected from the group consisting of a fluid permeable and microporous polymers;

(c) a container in the housing, the container consisting essentially of a collapsible wall surrounding a reservoir for storing the drug and a passageway that projects through the opening for delivering drug from the container to the exterior of the device, said container formed of a material selected from the group consisting of natural rubber, gutta, percha, cyclised rubber, synthetic rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, nitrile rubber, chloroprene rubber and ethylene-propylene rubber;

(d) a laminate in the housing, the laminate surrounding the container and comprising a lamina of an absorbent material and a lamina of a swellable hydrophilic polymer, said laminate capable of imbibing fluid into the housing through the polymer thereby causing the laminate to expand and exert pressure on the container which collapses said container and concomitantly pumps drug through the passageway from the device at a controlled rate over a prolonged period of time.

2. The drug delivery device according to claim 1, wherein the lamina formed of the absorbent material is formed of a member selected from the group consisting of wool, cotton, straw, flax, paper and mixtures thereof.

3. The drug delivery device according to claim 1, wherein the swellable hydrophilic polymer is cross-linked and it is a member selected from the group consisting of cross-linked poly(hydroxyalkyl methacrylate), poly(N-vinyl-2-pyrrolidone), polyelectrolyte complexes, poly(vinyl alcohol) cross-linked with glyoxal, formaldehyde or gluturaldehyde, and cross-linked cellulose.

4. The drug delivery device according to claim 1 wherein the drug is a member selected from the group consisting of locally and systemically acting gastrointestinal, nervous system, hypnotic, sedative, psychic energizer, tranquilzer, anticonvulsant, antiparkinson, muscle relaxant, analgesic, antipyretic, anti-inflammatory, anesthetic, antispasmodic, antimicrobial, antiviral, antiulcer, hormonal, sympthomimetic, diurectic, hypoglycemic, and anticontraceptive drugs.

5. The drug delivery device according to claim 14, wherein the drug in the container is mixed with a pharmaceutically acceptible carrier.