Haemodialyzer apparatus

• US 4,212,744 A
• Filed: 06/14/1978
• Issued: 07/15/1980
• Est. Priority Date: 06/21/1977
• Status: Expired due to Term

• Current Assignee: Asahi Medical Co. Ltd. (Asahi Kasei Corporation)
• Original Assignee: Asahi Medical Co. Ltd. (Asahi Kasei Corporation)
• Inventors: Oota, Kazuhiro
• Primary Examiner(s): Hart, Charles N.
• Assistant Examiner(s): Sadowski, David
• Application Number:
  US05/915,354
• Time in Patent Office: 762 Days
• Field of Search: 210/253, 210/295, 210/321 R, 210/321 A, 210/321 B, 210/321 UT, 210/340, 210/345, 210/433 M, 210/257 M, 210/DIG. 23, 210/323 T, 128/DIG. 3
• US Class Current: 210/321.64
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: B01D 61/145 Ultrafiltration
• CPC Class Codes: B01D 61/58 Multistep processes
• CPC Class Codes: B01D 63/04 comprising multiple hollow fibre assemblies
• CPC Class Codes: B01D 71/16 Cellulose acetate

Abstract

A haemodialyzer apparatus in which there are disposed two different types of membranes, namely, semi-permeable membranes that are substantially incapable of passing therethrough blood plasma proteins and filter membranes that are capable of passing therethrough blood plasma proteins. By the use of the present haemodialyzer apparatus, in addition to urea, creatinine and the like, the relatively high molecular weight substances such as the peptides having a molecular weight of more than 1,000 as well as the plasma proteins with their functions lowered, which relatively high molecular weight substances cannot be removed by any of the conventional haemodialyzers, can be effectively removed, to a desired extent, from the blood, thereby not only purifying or detoxifying the blood or components thereof but also recovering the toxic substances-absoring abilities of the plasma proteins so that the patients suffering from renal and/or liver failure may be remedied more satisfactorily.

Claims

1. In a haemodialyzer comprising a housing having an inlet and an outlet for blood and an inlet and an outlet for dialyzate, a plurality of membranes positioned in said housing and fixation block means for holding said membranes at their end portions, in a liquid tight connection, in relation to said housing wherein separate liquid passages for said blood and said dialyzate are formed by said plurality of membranes that are separately communicated with said inlet and outlet for blood and with said inlet and outlet for dialyzate, the improvement wherein said membranes comprise a first plurality of semi-permeable dialyzing membrane means substantially incapable of passing blood plasma proteins therethrough, said dialyzing membrane means contacting all components of said blood on one side thereof and contacting said dialyzate on the other side thereof, and a second plurality of filter membrane means for passing blood plasma proteins and for not passing blood corpuscles therethrough, wherein said dialyzing membrane means and said filter membrane means are held in said fixation block means.

2. A haemodialyzer apparatus according to claim 1 wherein said filter membrane means are present in a quantity of about 0.1 to 5% based on said semi-permeable membrane means, in terms of membrane area.

3. A haemodialyzer apparatus according to claim 2, wherein said filter membrane means are made of cellulose acetate.