Dialysis with ion exchange extraction of phosphates

• US 4,213,859 A
• Filed: 04/10/1978
• Issued: 07/22/1980
• Est. Priority Date: 04/12/1977
• Status: Expired due to Term

• Current Assignee: Cobe Nephross, B.V.
• Original Assignee: Akzo Nobel N.V. (Nouryon BV)
• Inventors: Smakman, Robert, van den Berg, Gerrit H.
• Primary Examiner(s): Castel, Benoit
• Assistant Examiner(s): Sadowski, David R.
• Application Number:
  US05/895,057
• Time in Patent Office: 834 Days
• Field of Search: 210/DIG. 23, 210/500 M, 210/321 R, 210/321 B, 210/433 M, 210/27, 210/282, 210/37 R, 210/37 B, 210/257 M, 210/22, 210/23 R, 210/36, 210/266, 210/295 , 210/259
• US Class Current: 210/638
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 47/585 Ion exchange resins, e.g. polystyrene sulfonic acid resin
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: B01J 39/04 Processes using organic exchangers
• CPC Class Codes: B01J 39/05 in the strongly acidic form
• CPC Class Codes: B01J 39/07 in the weakly acidic form
• CPC Class Codes: B01J 39/20 obtained by reactions only involving unsaturated carbon-to-carbon bonds
• CPC Class Codes: B01J 41/05 in the strongly basic form

Abstract

An apparatus for purifying blood has a blood compartment and a clearance compartment separated by a semi-permeable membrane. The apparatus includes a device containing a cation exchange resin charged with metal ions whose phosphates are insoluble in water. Metal salts of iron, aluminium, zirconium, lanthanum, thorium and tin are deposited on a cation exchange material and the charged cation exchange resin is contacted with dialysis liquid. The process of treating blood with the dialysis liquid is also contemplated.

Claims

1. An apparatus for the purification of blood comprising at least one selectively permeable membrane, a blood compartment on one side of the membrane and a clearance compartment on the other side thereof, means for passing through said compartments blood and a dialysis liquid, respectively, for removing the waste products from the blood, and a sorbent which is in contact with the clearance liquid and serves to extract phosphates from the liquid discharged from the clearance compartment, said sorbent being an organic cation exchanger charged with ions of a metal whose phosphate is poorly soluble in water.

2. The apparatus of claim 1, characterized in that as sorbent there is used an organic cation exchanger charged with ions of metals selected from the group of thorium, iron, tin, lanthanum, aluminium and zirconium.

3. The apparatus of claim 1 characterized in that the sorbent is an organic cation exchanger charged with iron ions.

4. The apparatus of claim 3, characterized in that the cation exchanger charged with iron ions is a cation exchanger charged with iron (III) ions.

5. The apparatus according to claim 1 characterized in that the cation exchanger contains weakly acid groups.

6. The apparatus according to claim 5, characterized in that the cation exchanger contains carboxylic acid groups, phosphonic acid groups and/or amidoxime groups.

7. The apparatus of claim 6, characterized in that the cation exchanger contains aminocarboxylic acid or iminodicarboxylic acid groups.

8. The apparatus according to claim 7, characterized in that the cation exchanger contains aminoacetic acid and/or iminodiacetic acid groups.

9. The apparatus according to claim 1 characterized in that the cation exchanger contains strongly acid groups.

10. The apparatus according to claim 9, characterized in that the cation exchanger contains sulphonic acid groups.

11. The apparatus of claim 9, characterized in that the macroporous matrix of the strongly acid cation exchanger has a high degree of cross-linking.

12. The apparatus of claim 1, characterized in that the matrix of the cation exchanger is a polymer or a polycondensation product of an aromatic compound or an acryl or methacryl compound or vinyl compound.

13. The apparatus of claim 1 characterized in that the matrix of the cation exchanger is macroporous.

14. The apparatus of claim 1, characterized in that the sorbent is also charged with alkaline earth metal ions.

15. The apparatus according to claim 14, characterized in that the sorbent is also charged with calcium ions and/or magnesium ions.

16. The apparatus according to claim 1, characterized in that the sorbent is included in capsules having a cationic semipermeable wall.

17. The apparatus according to claim 1, characterized in that it also contains an anion exchanger in contact with the clearance liquid which anion exchanger is at least partly charged with acetate ions and/or bicarbonate ions.

18. The apparatus according to claim 17, characterized in that the anion exchanger is strongly basic.

19. In a method of purifying blood which comprises treating the blood in a hemodialyzer with a dialysis liquid, the improvement which comprises contacting the blood with an ion exchange resin charged with metal ions which will combine with phosphate ions to form a phosphate which is substantially insoluble in blood.