Combination and method for mixing the contents of a blood collection tube and thereafter removing the mixing element

• US 4,214,874 A
• Filed: 02/08/1979
• Issued: 07/29/1980
• Est. Priority Date: 02/08/1979
• Status: Expired due to Term

• Current Assignee: Dade Behring, Inc. (Siemens AG)
• Original Assignee: American Hospital Supply Corp. (Baxter International Inc.)
• Inventors: White, Fred K.
• Primary Examiner(s): Turk, Arnold
• Application Number:
  US06/010,234
• Time in Patent Office: 537 Days
• Field of Search: 23/230 B, 422/99, 422/100, 366/243, 366/273, 366/332, 366/344, 366/348, 73/421 R, 73/425.4 P, 220/DIG. 19, 220/352, 128/1.3
• US Class Current: 73/864.01
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/150343 Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes sampling from within body cavities A61B5/150015, A61B5/150045
• CPC Class Codes: A61B 5/150587 by friction fit
• CPC Class Codes: A61B 5/150717 manually removed
• CPC Class Codes: A61B 5/150755 Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: B01F 31/441 performing a rectilinear reciprocating movement
• CPC Class Codes: B01F 33/452 using independent floating stirring elements
• CPC Class Codes: B01L 3/5082 Test tubes per se
• CPC Class Codes: Y10S 220/19 Rubber plugs and caps
• CPC Class Codes: Y10T 436/25 including sample preparation

Abstract

Combination and method for mixing a blood sample and an anticoagulant within a collection tube and for then capturing, removing and discarding the mixing element without danger of direct contact between the blood sample and the technician. The full combination includes a blood collection tube, at least one resilient end cap for the tube having a cavity which extends well beyond that tube when the cap is in place, a magnetic element slidable within the tube and receivable in the cap, and a magnet for shifting the magnetic element. After being directed into the cap following a mixing operation, the blood-covered magnetic element may be held within the cavity by finger pressure on the cap and discarded along with the cap.

Claims

1. A method for mixing blood with anticoagulant in a collection tube and thereafter safely removing the mixing element therefrom, said method involving the preliminary steps of drawing blood into a collection tube containing anticoagulant, introducing a magnetic element into said tube, sealing the ends of the tube, and thereafter moving a magnet back and forth along the outside of the tube to shift the magnetic element within the tube and thereby mix the blood and anticoagulant together, wherein the improvement comprises

utilizing an elongated tubular resilient cap as the means for sealing at least one end of said tube, said cap providing an elongated cavity having a mouth portion sealingly and removably receiving an end of said tube and having a main cavity portion extending beyond said tube, moving said magnet to shift said element into said cavity of said cap after said blood and anticoagulant have been mixed in said tube, and thereafter removing and discarding said cap with the blood-coated magnetic element captured therein.

2. The method of claim 1 in which the combined length of said mouth portion and said main portion of said cavity is substantially greater than the length of said magnetic element.

3. The method of claims 1 or 2 in which said step of removing said cap is accompanied by the further step of squeezing the portion of said cap extending beyond said tube between the user'"'"'s fingers so that said magnetic element is gripped and held between interior surface portions of said cap.

4. The method of claims 1 or 2 in which said magnet is annular and is loosely fitted about said tube for shifting said magnet during said mixing step, said step of moving said magnet to shift said element into the cavity of said cap including the step of moving said annular magnet off of said tube and axially away from said cap.

5. A method for mixing blood with anticoagulant in a blood collection tube and thereafter safely removing the mixing element from that tube, said method involving the preliminary steps of drawing blood into a standard blood collection tube containing anticoagulant, introducing a magnetic element into said tube, sealing the ends of said tube, and thereafter loosely fitting an annular magnet over said tube and moving said magnet back and forth along the length of said tube to shift said magnetic element within the tube and to mix the blood and anticoagulant therein, wherein the improvement comprises

utilizing an elongated tubular resilient cap as the means for sealing at least one end of said tube, said cap providing an elongated cavity having a mouth portion receivng said one end of said tube and having a main portion extending beyond said one end of said tube, moving said magnet off of said one end of said tube and away from said cap to shift said magentic element into the cavity of said cap after said blood and anticoagulant have been mixed together, squeezing the portion of said cap extending beyond said one end of said tube to hold said magnetic element within said cavity, and thereafter removing said cap and said magnetic element held therein from said tube and discarding said cap and the magnetic element captured therein.

6. A combination for mixing blood in a collection tube and for then removing and discarding the mixing element without danger of direct blood contact with the user, comprising an elongated blood collection tube having a bore for receiving a blood sample, means for sealing the ends of said tube, said means including a cap providing an elongated cavity having a mouth portion removably receiving one end of said tube and a main portion adapted to extend beyond said one end of said tube, a magnetic element slidable within said tube and dimensioned to be received within the cavity of said cap, and a magnet adapted to be moved along the outside of said tube for mixing the contents thereof and for thereafter shifting said magnetic element into said cap, whereby, said cap with said magnet captured therein may be removed and discarded without direct contact between the user and the contents of the tube.

7. The combination of claim 6 in which said magnetic element is rod-shaped and has a length substantially less than the length of said elongated cavity.

8. The combination of claim 6 in which said cavity of said cap is tapered.

9. The combination of claim 6 in which said magnet is annular and said cap has a maximum external diameter smaller than the inside diameter of said magnet.

10. The combination of claim 6 in which said cap is transparent.

11. The combination of claim 6 in which said cap includes an internal shoulder between said mouth portion and said main portion of said cavity, said shoulder being engageable with said one end of said tube to limit the insertion of said tube into said cavity.

12. The combination of claim 11 in which the smallest diameter of said shoulder is greater than the inside diameter of said collection tube.

13. The combination of claims 6, 7, 8, 9, 10, 11 or 12 in which said cap is formed of resilient plastic material, said cap having wall portions capable of being deformed inwardly when squeezed between a user'"'"'s fingers to engage and retain the magnetic element within said cap as said cap is removed from said tube and discarded.

14. A combination for use in mixing blood and anticoagulant within a blood collection tube and for thereafter removing and discarding the mixing element without danger of direct contact between the blood and a user, comprising a resilient cap provided with an elongated cavity having a mouth portion for sealingly but removably receiving an end of a blood collection tube and having a main portion adapted to extend beyond the end of such tube, a magnetic element dimensioned to slide within a blood collection tube and to fit within said cavity of said cap, said resilient cap having wall portions extending about said main portion of said cavity capable of being flexed inwardly to engage and grip said magnetic element when said element is disposed within said cavity and said wall portions are squeezed between a user'"'"'s fingers.

15. The combination of claim 14 in which said combination also includes an annular magnet for shifting said magnetic element through the bore of said tube and into said cap, said annular magnet having an inside diameter greater than the maximum outside diameter of said cap.

16. The combination of claims 14 or 15 in which said magnetic element is rod-shaped and has a length substantially less than the length of said elongated cavity.

17. The combination of claims 14 or 15 in which said cavity of said cap is tapered.

18. The combination of claim 14 in which said cap is transparent.

19. The combination of claim 14 in which said cap includes an internal shoulder between said mouth portion and said main portion of said cavity, said shoulder being adapted for engagement with the end of a blood collection to limit the extent of insertion of such tube into said cavity.