Device for removal of excess water from blood

• US 4,218,321 A
• Filed: 08/02/1978
• Issued: 08/19/1980
• Est. Priority Date: 08/05/1977
• Status: Expired due to Term

• Current Assignee: Agency of Industrial Science & Technology (Government of Japan), Ministry of International Trade & Industry (Government of Malaysia)
• Original Assignee: Agency of Industrial Science & Technology (Government of Japan), Ministry of International Trade & Industry (Government of Malaysia)
• Inventors: Okada, Akira, Suehiro, Tetsuro, Sasaki, Kanji
• Primary Examiner(s): Castel, Benoit
• Assistant Examiner(s): Sadowski, David R.
• Application Number:
  US05/930,159
• Time in Patent Office: 748 Days
• Field of Search: 210/321 B, 210/321 A, 210/DIG. 23, 210/317, 210/259, 210/22, 210/23 R, 210/39, 210/283, 210/284, 210/287, 210/291, 210/321 R, 210/27, 210/295, 210/266 , 210/500 M
• US Class Current: 210/259
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: B01D 61/28 Apparatus therefor
• CPC Class Codes: B01D 71/10 Cellulose; Modified cellulose

Abstract

A device for removal of excess water from blood is formed by having a plurality of solution chambers and a plurality of blood chambers arranged alternately, partitioning the adjoining ones of the alternately disposed chambers by insertion of semi-permeable membranes one each along the boundaries thereof and having a sorbent retained in the form of a bed inside the blood chambers, whereby the blood containing waste material and excess water in consequence of renal insufficiency is freed from such fouling substances by causing the blood to flow through the blood chambers in order for the beds of sorbent to deprive the blood of the waste material through sorption and for the high concentration solutions flowing through the adjoining solution chambers to deprive the blood of the excess water through osmosis effected through the medium of the semi-permeable membranes.

Claims

1. A device for the removal of excess water contained in the blood by utilization of osmotic pressure, which device comprises in combination:

a plurality of solution chambers possessed of one feed inlet connected to all of said solution chambers, said feed inlet having a pinch cock, and one constantly open discharge outlet connected to all of said solution chambers;

water suction means disposed inside said plurality of solution chambers for removing the excess water in the blood, said water suction means being a high concentration solution containing a concentration of 3.7-6 mol/liter solutes comprising calcium chloride, and one from the group consisting of glucose and sucrose,

said pinch cock permitting the passage of a fresh high concentration solution through said feed inlet into said plurality of solution chambers and thereby allowing the discharge of said high concentration solution in said plurality of solution chambers out of said discharge outlet when said pinch cock is opened;

a plurality of blood chambers allowing the blood subjected to perfusion treatment to pass therethrough, said solution chambers and said blood chambers being alternately disposed; and

a plurality of normal osmotic semi-permeable membranes inserted to partition the adjoining ones of the alternately disposed chambers, said semi-permeable membranes exhibiting solute permeability for said solutions in the range of from 1×

10^-7 cm/min. to 7×

10^-6 cm/min. at the time said semi-permeable membranes have come into contact with said high concentration solution at one side thereof and with the blood at the other side thereof, whereby the excess water contained in the blood is allowed to pass through said semi-permeable membranes by osmotic pressure into said solution chambers and said solutes contained in said high concentration solution are prevented from passing through said semi-permeable membranes into said blood chambers.

2. The device according to claim 1, wherein the blood chambers retain therein a sorbent wrapped up in a liquid-previous substance.

3. The device according to claim 2, wherein the sorbent is in the form of spheres of activated carbon.

4. The device according to claim 1, which further comprises means for supplying to said blood chambers blood which has been treated in advance with a sorbent.

5. The device according to claim 1, which further comprises means for treating blood with a sorbent after the blood has passed through said blood chambers.

6. The device according to claim 1, wherein said semi-permeable membranes are made of acetyl cellulose with a degree of acetylation of 60.5%.