Prefilled, vented two-compartment syringe

• US 4,226,236 A
• Filed: 05/07/1979
• Issued: 10/07/1980
• Est. Priority Date: 05/07/1979
• Status: Expired due to Term

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Genese, Joseph N.
• Primary Examiner(s): Yasko, John D.
• Application Number:
  US06/036,927
• Time in Patent Office: 519 Days
• Field of Search: 128/218 M, 128/272.1, 128/215, 128/216, 128/234, 128/218 D, 128/218 DA, 128/218 R, 128/218 P, 128/235
• US Class Current: 604/89
• CPC Class Codes: A61M 2005/3123 having air entrapping or venting means, e.g. purging channels in pistons
• CPC Class Codes: A61M 2005/31506 formed as a single piece, e.g. moulded
• CPC Class Codes: A61M 5/284 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/288 by piercing without internal pressure increase A61M5/283 takes precedence
• CPC Class Codes: A61M 5/3134 characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
• CPC Class Codes: A61M 5/3145 Filters incorporated in syringes
• CPC Class Codes: A61M 5/315 Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms

Abstract

A prefilled, readily activated syringe assembly wherein a fluid medicament and a diluent therefor can be intermixed in a syringe barrel with a venting thereof. A medical powder is sealed in a barrel by means of an intermediate slidable stopper and the diluent is sealed in the same barrel between the stopper and a plunger stopper. A bypass channel is provided in the syringe barrel which permits intermixing of the diluent and the medicament when the plunger stopper is moved toward the intermediate stopper. Movement of the plunger stopper inwardly in the barrel is afforded by means of a hydrophobic filter element associated with the nozzle portion. After intermixing of the diluent and the medicament the filter vent is pierced by means of a piercing tubular member to which is attached a hypodermic needle. Continued movement of the plunger stopper will expel the mixed medicament from the syringe.

Claims

1. A prefilled, vented, readily activated syringe assembly adapted to receive a hypodermic needle comprising:

a barrel member defining a substantially tubular chamber having a wall portion;

a nozzle portion communicating with said tubular chamber;

a hydrophobic filter element operatively associated with said nozzle portion of said barrel member;

a holder member in sealing arrangement with said nozzle portion and positioned outwardly from said filter element;

means to retain said holder member on said nozzle portion;

passage means defined by said holder element;

a piercing tubular member having a piercing point, slidably positioned in said passage means of said holder member and said piercing point spaced from said filter element;

a first stopper in slidable and sealing engagement in said tubular chamber to provide a compartment for a first flowable medicinal material;

a second stopper adapted to receive a plunger rod in slidable and sealing engagement in said tubular chamber of said barrel member and spaced from said first stopper to provide a compartment for a second flowable medicinal material;

means constructed and arranged in combination with said first and second stoppers and said barrel member to provide upon movement of said first stopper toward said second stopper fluid communication between said compartments for said first and second medicinal materials;

whereby upon movement of said second stopper in the direction of said first stopper, intermixing of said first and second medicinal materials will be effected with emission of air through said filter element;

upon subsequent movement of said piercing tubular member toward said filter with a piercing thereof;

attachment of said hypodermic needle to said piercing tubular member; and

upon further movement of said second stopper toward said first stopper substantially;

all of said medicinal materials will be expelled from said syringe.

2. The prefilled, vented, readily activated syringe assembly as defined in claim 1 further including a second filter element secured to said piercing tubular member at an end opposite said piercing point.

3. The prefilled, vented, readily activated syringe assembly as defined in claim 2 wherein said piercing tubular member defines a male luer adapter portion for attachment to said second filter element and said hypodermic needle.

4. The prefilled, vented, readily activated syringe assembly as defined in claim 2 wherein said holder member is composed of a resilient material and said passage means and said piercing tubular member defines a slidable frictional engagement means for said piercing tubular member.

5. The prefilled, vented, readily activated syringe assembly as defined in claim 4 wherein said slidable frictional engagement is defined by at least one projection extending from said piercing tubular member and an accommodating groove in said holder member.

6. The prefilled, vented, readily activated syringe assembly as defined in claim 1 wherein said piercing tubular member includes a flange for contact with said holder member after said piercing point pierces said hydrophobic filter element.

7. The prefilled, vented, readily activated syringe assembly as defined in claim 5 wherein said nozzle portion defines a flange portion, said syringe assembly includes an annular support with a flange section seated on said flange portion of said nozzle portion, said hydrophobic filter element is secured to said annular support and said holder member includes a shoulder section for holding said flange section of said annular support against said flange portion of said nozzle portion.

8. The prefilled, vented, readily activated syringe assembly defined in claim 7 wherein said annular support is dimensioned to position said filter element within the confines of said nozzle portion.

9. The prefilled, vented, readily activated syringe system as defined in claim 7 further including an annular sealing element positioned between said flange section of said annular support and said flange portion of said nozzle portion and said filter element is positioned outside the confines of said nozzle portion.

10. The prefilled, vented, readily activated syringe assembly as defined in claim 5 wherein said nozzle portion defines a flange portion, said holder member includes a shoulder for seating on said flange portion and a compartment for housing said filter element and said syringe assembly includes a filter retaining member for seating in said compartment and retaining said filter therein.

11. The prefilled, vented, readily activated syringe assembly as defined in claims 7 or 10 further including removable closure means for surrounding said holder member for securing said closure means to said flange portion of said nozzle portion.

12. A prefilled, vented, readily activated syringe assembly adapted to receive a hypodermic needle comprising:

a barrel member defining a substantially tubular chamber having a wall portion with a bypass channel formed in said wall portion;

a nozzle portion communicating with said tubular chamber;

a hydrophobic filter element in sealing engagement with said nozzle portion of said barrel member;

a holder member in sealing engagement with said nozzle portion and positioned outwardly from said filter element;

passage means defined by said holder element;

a piercing tubular member having a piercing point, slidably positioned in said passage means of said holder member and said piercing point spaced from said filter element;

a first stopper in slidable and sealing engagement in said tubular chamber and spaced from said bypass channel opposite said nozzle portion to provide a compartment for a first flowable medicinal material;

a second stopper adapted to receive a plunger rod in slidable and sealing engagement in said tubular chamber of said barrel member and spaced from said stopper to provide a compartment for a second flowable medicinal material;

whereby upon movement of said second stopper in the direction of said first stopper, said first stopper will move adjacent said bypass channel to thereby permit intermixing of said first and second medicinal materials with emission of air through said filter element;

upon subsequent movement of said piercing tubular member toward said filter with a piercing thereof;

attachment of said hypodermic needle to said piercing tubular member; and

upon further movement of said second stopper toward said first stopper substantially all of said medicinal materials will be expelled from said syringe.

13. The prefilled, vented, readily activated syringe assembly as defined in claim 12 further including a second hydrophobic filter element secured to said piercing tubular member at an end opposite said piercing point.

14. The prefilled, vented, readily activated syringe assembly as defined in claim 13 wherein said first flowable medicinal material is solid material in powder form and said second material is a liquid.

15. The prefilled, vented, readily activated syringe assembly as defined in claim 14 further including a removable closure means positioned over said holder member and secured to said nozzle portion.

16. The prefilled, vented, readily activated syringe assembly as defined in claim 15 wherein said syringe barrel is formed from glass and all of said other components are formed from materials other than glass.