Optical density detector

• US 4,227,814 A
• Filed: 02/01/1979
• Issued: 10/14/1980
• Est. Priority Date: 02/01/1979
• Status: Expired due to Term

• Current Assignee: Baxter Travenol Laboratories Incorporated
• Original Assignee: Baxter Travenol Laboratories Incorporated
• Inventors: Lohr, David, Soodak, Charles, Lamadrid, Rene G.
• Primary Examiner(s): Evans, F. L.
• Application Number:
  US06/008,274
• Time in Patent Office: 621 Days
• Field of Search: 356/39-41, 356/410, 356/414, 356/436, 356/440, 356/246, 250/573-576
• US Class Current: 356/410
• CPC Class Codes: A61M 1/1692 Detection of blood traces in dialysate
• CPC Class Codes: A61M 1/3696 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: A61M 2205/3313 used specific wavelengths
• CPC Class Codes: B04B 13/00 Control arrangements specially designed for centrifuges; Programme control of centrifuges control arrangements for feed, charge, or discharge B04B11/00
• CPC Class Codes: B04B 5/0442 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: G01N 2021/0364 flexible, compressible
• CPC Class Codes: G01N 21/85 Investigating moving fluids or granular solids

Abstract

The optical detector is particularly adapted for use with an apparatus for separating blood into its components and is of the type including a centrifuge for centrifuging whole blood to separate same into the components thereof and of the type wherein plasma is withdrawn from the centrifuge through a flexible, light transmitting tubing and the spillover of red blood cells into the plasma withdrawn is monitored by the optical detector. The optical detector comprises a block having a slot across the top face thereof, the inner portion of the slot having a width less than the outer diameter of the tubing which is received in the slot such that when the tubing is pressed into the slot, it is squeezed from a circular cross section to an oval cross section to present two flat portions of the tubing adjacent opposite sidewalls of the slot. A first cavity is situated in the block behing a first sidewall of the slot and a second cavity is situated in the block behind a second sidewall of the slot. Apertures are provided in the sidewalls and light from a light source is directed along the axis of the apertures, through lenses in the cavities which seal the cavities from the slot and through the tubing in the slot from the first cavity to the second cavity where a photosensor is located. The photosensor is operable to generate an electrical signal which is indicative of the light sensed and which can be utilized for measuring the optical density of the plasma flowing through the tubing.

Claims

1. An optical density detector for sensing the change in optical density of a fluid flowing in a flexible, light transmitting tubing, said detector comprising a block having a slot across one face thereof, the inner portion of said slot having a width less than the outer diameter of the tubing which is received in said slot such that the tubing is squeezed from a circular cross section to an oval cross section with two respective flat portions adjacent opposite sidewalls of said slot, a first cavity in said block located behind a first sidewall of said slot and a second cavity in said block located behind a second sidewall of said slot, a first aperture in said first sidewall and a second aperture in said second sidewall, said apertures being coaxial, low power light generating means for directing light from said first cavity through said first aperture, through the flat portions of the tubing and through said second aperture into said second cavity and light sensing means in said second cavity for sensing the amount of light passed through the tubing and received in said second cavity and for generating an electrical signal which is indicative of the amount of light sensed and which can be utilized for measuring the optical density of the fluid flowing through the tubing, and said block being constructed in a manner to dissipate heat generated by said light generating means.

2. The detector according to claim 1 including first and second clear borosilicate glass filters, each fixed in one of said first and second cavities adjacent said first or second sidewall and each providing a fluid seal between said slot and said first or second cavity.

3. The detector according to claim 2 including a colored glass filter situated between said light sensing means and said clear borosilicate glass filter in said second cavity.

4. The detector according to claim 1 wherein said block has an elongate third cavity with an elongate axis normal to the axis of said apertures with one end opening into said first cavity, and wherein said light generating means includes an electrical lamp in said third cavity and a reflecting member mounted in said first cavity at an angle of 45 degrees, said elongate axis and said aperture axis intersecting at the surface of said reflecting member.

5. The detector according to claim 4 wherein said electric lamp received in said third cavity comprises a low wattage "pen" lamp which emits a strong light beam along the elongate axis thereof, said lamp being mounted in said elongate third cavity with said elongate axis thereof coaxial with said elongate axis of said third cavity.

6. The detector according to claim 5 wherein said lamp has a light output of approximately 750 foot candles at a power consumption of between 1 and 2 watts.

7. The detector according to claim 1 wherein said sensing means comprises a photosensor having a short response time, low drift and low memory.

8. The detector according to claim 1 particularly adapted for use with a blood separating apparatus of the type including a centrifuge for centrifuging whole blood to separate the whole blood into the components thereof and of the type wherein plasma is withdrawn from the centrifuge through the flexible tubing and wherein said detector is utilized to monitor the plasma being withdrawn from the centrifuge device and to detect the spillover of red blood cells into the plasma being withdrawn, and wherein said detector includes a blue green glass filter for passing blue green light at approximately 550 nonometers so that the detector is highly sensitive to the absorption of blue green light by oxygenated hemoglobin in red blood cells to quickly detect the spillover of red blood cells into the plasma.

9. The detector according to claim 8 wherein said light sensing means comprises a photosensor which has a short response time, low drift and low memory and which is highly sensitive to blue green light.

10. The detector according to claim 9 wherein said photosensor is a type 9 cadmium sulfide photocell having a peak response at approximately 550 nanometers.

11. The detector according to claim 1 wherein said block is made of a heat conductive material and has a mass sufficient to dissipate heat generated by said light generating means thereby to prevent such heat from adversely affecting the operation of said light sensing means.

12. The detector according to claim 11 wherein said block is made of a heat conducting material having a high thermal conductivity.

13. The detector according to claim 12 wherein said block has a mounting flange integral therewith which forms part of the heat dissipation structure of said block and which is adapted to be mounted to and between heat conducting frame members.

14. The detector according to claim 1 wherein said block includes a generally rectangular base integral therewith and forming a mounting flange, said slot being formed in the top face of said block and said block having four sides with said slot extending between one pair of oppositely facing sides and said first and second cavities being formed by coaxial bores extending into respective ones of the other pair of oppositely facing sides.

15. The detector according to claim 14 having a third bore extending upwardly from the bottom of said block to said first cavity.

16. The detector according to claim 15 having a fourth bore extending upwardly from the bottom of said block to said second cavity.