Peristaltic dialysate solution pump

• US 4,229,299 A
• Filed: 03/22/1978
• Issued: 10/21/1980
• Est. Priority Date: 03/22/1978
• Status: Expired due to Term

• Current Assignee: Hoechst Aktiengesellschaft (Sanofi )
• Original Assignee: Hoechst Aktiengesellschaft (Sanofi )
• Inventors: Savitz, Steven R., Drago, James A.
• Primary Examiner(s): Spear, Jr., Frank A.
• Application Number:
  US05/888,858
• Time in Patent Office: 944 Days
• Field of Search: 210/321 B, 210/22 A, 210/96 M, 210/85, 210/186, 210/195 R, 210/416 M, 210/137, 210/180, 210/188, 417/477, 417/53
• US Class Current: 210/85
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/1658 Degasification
• CPC Class Codes: A61M 1/1662 with heat exchange between fresh and used dialysate
• CPC Class Codes: A61M 1/1668 Details of containers
• CPC Class Codes: F04B 43/1215 having no backing plate (deforming of the tube only by rollers)

Abstract

Peristaltic pump means for pumping dialysate solution through a dialysate solution flow circuit in a hemodialysis system. The pump comprises four rollers mounted on a rotatable base member with a relatively long segment of flow circuit tubing tensionally extended around the pump head so as to be simultaneously engaged and compressed by at least two of the rollers, the rollers being mounted for longitudinal movement of the points of compression along the tubing during rotation of the pump head assembly to advance dialysate solution through the flow circuit. The disclosed pump means provides a substantially uniform dialysate solution flow rate under conditions of varying dialysate solution negative pressure and is particularly suitable for use in a unitary, portable hemodialysis module of a type adapted for coupling with either a single-pass proportioning system or a batch dialysate solution supply. A proportioning system is disclosed for such arrangement which employs a recirculating deaeration means for removal of soluble gases from the water employed for make-up of dialysate solution. The peristaltic dialysate solution pump is mounted in the portable hemodialysis module in a manner which facilitates rapid changeover from single-pass to batch dialysate solution flow, and vice versa.

Claims

1. Peristaltic pump means for use in hemodialysis apparatus, comprising a rotatable pump head assembly including a base member positioned for rotation about a fixed axis with four circumferentially spaced apart rollers mounted thereon for independent rotation about respective axes parallel to the base member fixed axis;

flexible resilient tubing through which a negative pressure fluid is pumped;

means for anchoring end segments of the flexible resilient tubing such that the tubing is tensionally extended around the pump head assembly, being simultaneously engaged and compressed by at least two of said circumferentially spaced apart rollers, said rollers being mounted for longitudinal movement of the points of compression along the tubing during rotation of said pump head assembly to advance fluid through said tubing;

each of said four rollers having a generally convex surface profile, for only partial closure of the tubing at the points of compression by said rollers, and circumferentially spaced 90°

apart from adjacent rollers;

said flexible resilient tubing having a length, as measured longitudinally along the tubing between the anchored end segments thereof, of from 6.75 to 11.0 inches, a wall thickness no greater than 0.125 inch, and an internal diameter no greater than 0.35 inch; and

drive means coupled to said pump head assembly for rotation thereof.

2. The invention of claim 1 wherein said peristaltic pump means is mounted for service in a unitary enclosure dialysis module.

3. The invention of claim 1 wherein the flexible resilient tubing is formed of a silicone elastomer.

4. The invention of claim 3 wherein said silicone elastomer has a durometer value of from 40 to 60.

5. Hemodialysis apparatus for treatment of blood to remove waste impurities therefrom, including:

dialyzer means through which waste impurity-containing blood and a dialysate solution are passed in indirect mass transfer dialyzing relationship for transfer of said waste impurities from said blood to said dialysate solution;

means for transferring waste impurity-containing blood from a patient to said dialyzer means including a flexible resilient tubing pumping section through which blood is pumped and means for returning waste impurity-depleted blood to said patient forming a blood flow circuit;

means for transferring dialysate solution from a negative pressure dialysate solution source to said dialyzer means and means for discharging waste impurity-enriched dialysate solution from said dialyzer means forming a dialysate solution flow circuit including a flexible resilient tubing pumping section through which dialysate solution is pumped;

peristaltic blood pump means disposed in said blood flow circuit and peristaltic dialysate pump means disposed in said dialysate solution flow circuit each pump means comprising a rotatable pump head assembly including a base member positioned for rotation about a fixed axis with a plurality of circumferentially spaced apart rollers mounted thereon for independent rotation about respective axes parallel to the base member fixed axis, at least said peristaltic dialysate pump means having four spaced apart rollers mounted on the base member thereof;

means for anchoring the end segments of the flexible resilient tubing pumping section in said blood flow circuit and means for anchoring the end segments of the flexible resilient tubing pumping section in said dialysate solution flow circuit such that the tubing in each circuit is tensionally extended around the pump head assembly of a respective one of said peristaltic pump means and is simultaneously engaged and compressed by at least two of said circumferentially spaced apart rollers of the respective peristaltic pump means, the rollers of each peristaltic pump means being mounted for longitudinal movement of the points of compression along the associated tubing during rotation of said pump head assembly to advance fluid through said tubing;

each of said four rollers in at least the peristaltic dialysate pump means having a generally convex surface profile, for only partial closure of the tubing at the points of compression by the rollers, with a maximum diameter between 0.25 and 0.75 inch and circumferentially spaced 90°

apart from adjacent rollers with a radial distance between the roller axis and said base member fixed axis of from 0.50 to 1.50 inches;

said flexible resilient tubing pumping section in the dialysate flow circuit having a length, as measured longitudinally along the tubing between the anchored end segments thereof, of from 6.75 to 11.0 inches, a wall thickness of from 0.07 to 0.125 inch, and an internal diameter of from 0.18 to 0.35 inch; and

drive means coupled to the pump head assembly of the peristaltic dialysate pump means for rotation thereof at a speed in the range of from 150 to 400 rpm.

6. Apparatus according to claim 5 wherein a portion of said dialysate solution flow circuit, including said peristaltic dialysate pump means, is disposed in a unitary enclosure dialysis module, with said dialysate solution flow circuit portion being alternatively and detachably interconnectable with either a dialysate solution proportioning system, for single-pass flow of dialysate solution through said dialysate solution flow circuit, or a dialysate solution supply container, for batch recirculation of dialysate solution through said dialysate solution flow circuit.

7. Apparatus according to claim 6 wherein said proportioning system comprises means for providing a continuous flow of water at elevated temperature to proportioning means wherein said water and a dialysate concentrate are mixed together in a predetermined ratio to form said dialysate solution, said means for providing a continuous flow of water at elevated temperature including water source means and means for heating water from said source means to said elevated temperature, and deaeration means for removing soluble gases from the heated water prior to passage thereof to said proportioning means, said deaeration means including:

(a) a first reservoir receiving heated water from said heating means, having venting means to permit gases desolubilized from said water in said heating to disengage from the heated water to form partially deaerated water;

(b) a vacuum pump;

(c) a conduit joining said first reservoir with an inlet of said vacuum pump for passage of said partially deaerated water from said first reservoir to said vacuum pump;

(d) adjustable flow restriction means disposed in said conduit for reduction in pressure of the partially deaerated water passed through said conduit to further desolubilize gases therefrom and form lower pressure water with desolubilized gas dispersed therein;

(e) a conduit joined at one end to an outlet of said vacuum pump for discharging higher pressure water with desolubilized gas dispersed therein from said pump;

(f) a second reservoir joined to the other end of said conduit (e) for receiving discharged higher pressure water therefrom, having venting means to permit said desolubilized gas to disengage from said higher pressure water to form finally deaerated water; and

(g) means for transferring said finally deaerated water from said second reservoir to said proportioning means,

wherein said proportioning means are joinable to said dialysate solution flow circuit to supply dialysate solution to same.

8. Apparatus according to claim 7 wherein said deaeration means further include:

overflow discharge means for maintaining liquid level in said first reservoir below a predetermined level; and

a conduit joining said first reservoir with said second reservoir for recirculation of a portion of said finally deaerated water from said second reservoir to said first reservoir to enhance removal of soluble gases by said deaeration means.

9. Apparatus according to claim 6 wherein the remainder of said dialysate solution flow circuit is detachably coupled to said flexible resilient tubing pumping section thereof.

10. Apparatus according to claim 7 wherein said proportioning system is mounted for service in a unitary enclosure as a dialysate solution supply module.

11. Apparatus according to claim 5 wherein said dialysate flow circuit forms a closed loop with said dialysate solution source for batch recirculation of said dialysate solution through said dialyzer means.

12. Apparatus according to claim 5 wherein said dialysate solution source comprises proportioning means for continuously mixing water from a source of same with dialysate concentrate to form said dialysate solution and wherein said dialysate solution is flowed through said dialysate solution flow circuit in single pass flow.

13. Apparatus according to claim 5 wherein said dialysate solution flow circuit includes a portion upstream of said dialyzer means with which are associated:

means for heating said dialysate solution;

means for sensing the temperature of said dialysate solution disposed downstream from said heating means and for adjusting the rate of heating of said dialysate solution by said heating means in response to said temperature sensing to maintain a predetermined dialysate solution temperature level; and

means for sensing the electrolytic conductivity of said dialysate solution.

14. Apparatus according to claim 13 wherein means for detecting blood leakage are associated with a dialysate solution flow circuit portion downstream of said dialyzer means.

15. Apparatus according to claim 13 comprising:

means for converting said dialysate solution temperature sensing into a transmittable signal;

means for transmitting said temperature sensing signal;

visual display means coupled with said temperature sensing means by said signal transmitting means for indication of said sensed dialysate solution temperature;

means for converting said dialysate solution electrolytic conductivity into a transmittable signal;

means for transmitting said electrolytic conductivity sensing signal; and

visual display means coupled with said electrolytic conductivity sensing means by said conductivity signal transmitting means for indication of said sensed dialysate solution electrolytic conductivity.

16. Apparatus according to claim 5 wherein said dialysate solution flow circuit has associated therewith in a portion of said circuit upstream of said dialyzer means:

(a) means for heating said dialysate solution;

(b) means for sensing the temperature of said dialysate solution and adjusting the rate of heating of said dialysate solution by said heating means in response to said temperature sensing to maintain a predetermined dialysate solution temperature level;

(c) means for converting said dialysate solution temperature sensing into a transmittable signal;

(d) means for transmitting said temperature sensing signal;

(e) visual display means coupled with said temperature sensing means by said signal transmitting means for indication of said sensed dialysate solution temperature;

(f) means for sensing the electrolytic conductivity of said dialysate solution;

(g) means for converting said dialysate solution electrolytic conductivity into a transmittable signal;

(h) means for transmitting said electrolytic conductivity sensing signal; and

(i) visual display means coupled with said electrolytic conductivity sensing means by said conductivity signal transmitting means for indication of said sensed dialysate solution electrolytic conductivity; and

a portion of said dialysate solution flow circuit downstream of said dialyzer means has associated therewith (j) means for detecting blood leakage;

wherein said dual peristaltic pump means, anchoring means, pump drive means, and said means (a)-(j) associated with said dialysate solution flow circuit are mounted for service in a unitary enclosure.

17. Apparatus according to claim 5 wherein said flexible resilient tubing pumping section in the dialysate solution flow circuit has a length of 7 to 10 inches.

18. Apparatus according to claim 5 wherein the ratio of said wall thickness to said internal diameter of said flexible resilient tubing pumping section in the dialysate solution flow circuit is in the range of from 0.35 to 0.40.