Somatostatin analogues
First Claim
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1. A compound of the formula:
- ##STR3## its linear precursor intermediates or non-toxic acid addition salts thereof in whichX2 is NH2, Ala-Gly-, Ala-D-Ala, Gly-Gly-Gly-, lower alkanoyl or benzoyl;
X4 is Arg, His, D-Arg, or D-His;
X5 is His, Tyr, Glu, D-His, D-Tyr, or D-Glu;
X7 is Trp, Tyr, Met, or His;
andX8 is Trp or D-Trp.
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Abstract
The polypeptides, ##STR1## the linear precursor intermediates therefor or non-toxic acid addition salts thereof in which
X2 is NH2, Ala-Gly-, Ala-D-Ala-, Gly-Gly-Gly-, lower alkanoyl or benzoyl;
X4 is Arg, His, D-Arg or D-His;
X5 is His, Tyr, Glu, D-His, D-Tyr or D-Glu;
X7 is Trp, Tyr, Met or His;
and
X8 is Trp or D-Trp;
inhibit the release of growth hormone and are useful in the treatment of acromegaly and diabetes.
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4 Claims
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1. A compound of the formula:
- ##STR3## its linear precursor intermediates or non-toxic acid addition salts thereof in which
X2 is NH2, Ala-Gly-, Ala-D-Ala, Gly-Gly-Gly-, lower alkanoyl or benzoyl; X4 is Arg, His, D-Arg, or D-His; X5 is His, Tyr, Glu, D-His, D-Tyr, or D-Glu; X7 is Trp, Tyr, Met, or His; and X8 is Trp or D-Trp. - View Dependent Claims (2, 3, 4)
- ##STR3## its linear precursor intermediates or non-toxic acid addition salts thereof in which
Specification