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Cyclic hexapeptide somatostatin analogs

  • US 4,235,886 A
  • Filed: 10/31/1979
  • Issued: 11/25/1980
  • Est. Priority Date: 10/31/1979
  • Status: Expired due to Term
First Claim
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1. A compound having the formula:

  • ##STR15## wherein X is (CH2)n wherein n is 0, 1 or 2 or sulfur;

    Y is (CH2)m wherein m is 0, 1 or 2 or sulfur such that the sulfur may be in any position along the chain;

    R1 and R2 are independently lower alkyl, benzyl, substituted benzyl wherein the substituent may be one or two of loweralkyl, halogen, hydroxy, amino, nitro or loweralkoxy; and

    loweralkyl substituted with a 5- or 6-membered heterocyclic ring;

    R3 is 3-indolylmethyl or substituted 3-indolylmethyl wherein the substituent may be loweralkyl, loweralkoxy or halogen; and

    R4 is loweralkyl, hydroxyloweralkyl, benzyl, carboxyloweralkyl, aminoloweralkyl or substituted hydroxy benzyl wherein the substituent may be loweralkyl, loweralkoxy, hydroxy, halogen, amino or nitro.

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