Hypoglycaemically and hypolipidaemically active derivatives of phenyl-alkane-carboxylic acids
First Claim
1. A phenyl-alkane-carboxylic acid of the formula ##STR14## wherein A is an aryl, aralkyl or arylvinyl radical optionally substituted by hydroxy, halogen, trifluoromethyl, alkyl, alkylthio, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino, aryloxy or alkoxy-substituted aryloxy, or is an aryloxyalkyl or arylthioalkyl radical, or a thienyl or quinolyl radical optionally substituted by halogen, or alkyl or alkoxy containing up to 5 carbon atoms, any aryl moiety of A containing from 6 to 10 carbon atoms and any alkyl, alkoxy or alkenyloxy moiety of A containing 2 5 carbon atoms,Y is an unbranched or branched lower alkylene radical containing up to 3 carbon atoms,X is a straight or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing 2 to 8 carbon atoms, there being at least 2 carbon atoms between the benzene ring and the carboxyl group, andR is a hydrogen atom or a lower alkyl radical containing up to 5 carbon atoms,or a physiologically compatible salt, ester or amide thereof.
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Abstract
Phenyl-alkane-carboxylic acids of the formula ##STR1## wherein A is an aryl, aralkyl or arylvinyl radical optionally substituted by hydroxy, halogen, trifluoromethyl, alkyl, alkylthio, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino, aryloxy or alkoxy-substituted aryloxy, or is an aryloxyalkyl or arylthioalkyl radical, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy,
Y is a valency bond or an unbranched or branched lower alkylene radical containing up to 3 carbon atoms,
X is a straight or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing 2 to 8 carbon atoms, there being at least 2 carbon atoms between the benzene ring and the carboxyl group, and
R is a hydrogen atom or a lower alkyl radical, as well as physiologically compatible salts, esters and amides thereof, exhibit hypoglycaemic and hypolipidaemic activity.
100 Citations
9 Claims
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1. A phenyl-alkane-carboxylic acid of the formula ##STR14## wherein A is an aryl, aralkyl or arylvinyl radical optionally substituted by hydroxy, halogen, trifluoromethyl, alkyl, alkylthio, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino, aryloxy or alkoxy-substituted aryloxy, or is an aryloxyalkyl or arylthioalkyl radical, or a thienyl or quinolyl radical optionally substituted by halogen, or alkyl or alkoxy containing up to 5 carbon atoms, any aryl moiety of A containing from 6 to 10 carbon atoms and any alkyl, alkoxy or alkenyloxy moiety of A containing 2 5 carbon atoms,
Y is an unbranched or branched lower alkylene radical containing up to 3 carbon atoms, X is a straight or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing 2 to 8 carbon atoms, there being at least 2 carbon atoms between the benzene ring and the carboxyl group, and R is a hydrogen atom or a lower alkyl radical containing up to 5 carbon atoms, or a physiologically compatible salt, ester or amide thereof.
Specification
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- Resources
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Current AssigneeBoehringer Mannheim GmbH (Roche Holding AG)
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Original AssigneeBoehringer Mannheim GmbH (Roche Holding AG)
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InventorsBosies, Elmar, Heerdt, Ruth, Schmidt, Felix H., Stach, deceased, Kurt, Kuhnle, Hans-Frieder
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Primary Examiner(s)Reamer, James H.
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Application NumberUS05/920,508Time in Patent Office894 DaysField of Search424/319, 424/309, 424/258, 424/275, 560/37, 560/42, 562/442, 562/451, 260/332.2 C, 546/169US Class Current514/563CPC Class CodesC07C 2603/18 Fluorenes; Hydrogenated flu...C07D 213/82 in position 3C07D 241/24 Carbon atoms having three b...C07D 307/79 with only hydrogen atoms, h...C07D 311/66 with carbon atoms having th...C07D 333/38 Carbon atoms having three b...
