Apparatus for producing gradient elution in a liquid chromatographic system
First Claim
1. An apparatus for producing gradient elution in a liquid chromatographic system, said apparatus comprisingvariable dosing means for at least two different solvents said dosing means including variable flow resistances for said solvents;
- mixing means for mixing said solvents and delivering a solvent mixture;
pump means for feeding said solvent mixture to a chromatographic column;
density measuring means for measuring the density of said solvent mixture said density being a function of the mixing ratio of said different solvents; and
control means responsive to said density measuring means for adjusting said flow resistances in accordance with a given nominal density curve corresponding to a desired elution gradient.
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Abstract
An aparatus for producing gradient elution in a liquid chromatographic system is diclosed. The apparatus comprises variable dosing means for at least two different solvents said dosing means including variable flow resistances for said solvents. A mixing means is provided for mixing said solvents and delivering a solvent mixture which is fed by pump means to a chromatographic column. Density measuring means is provided for measuring the density of said solvent mixture which density is a function of the mixing ratio of said different solvents. Control means responsive to said density measuring means adjust said flow resistances in accordance with a given nominal density curve corresponding to a desired elution gradient.
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Citations
3 Claims
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1. An apparatus for producing gradient elution in a liquid chromatographic system, said apparatus comprising
variable dosing means for at least two different solvents said dosing means including variable flow resistances for said solvents; -
mixing means for mixing said solvents and delivering a solvent mixture; pump means for feeding said solvent mixture to a chromatographic column; density measuring means for measuring the density of said solvent mixture said density being a function of the mixing ratio of said different solvents; and control means responsive to said density measuring means for adjusting said flow resistances in accordance with a given nominal density curve corresponding to a desired elution gradient. - View Dependent Claims (2, 3)
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Specification
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Current AssigneeHewlett-Packard Company (HP Inc.)
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Original AssigneeHewlett-Packard Company (HP Inc.)
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InventorsSchrenker, Helge
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Primary Examiner(s)Adee, John
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Application NumberUS06/110,285Time in Patent Office344 DaysField of Search210/198 C, 210/96.1, 73/61.1 CUS Class Current210/96.1CPC Class CodesB01D 15/08 Selective adsorption, e.g. ...G01N 30/34 of fluid composition, e.g. ...G05D 21/02 characterised by the use of...
