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Anti-thrombogenic PVP-heparin polymer

  • US 4,239,664 A
  • Filed: 10/31/1978
  • Issued: 12/16/1980
  • Est. Priority Date: 10/31/1978
  • Status: Expired due to Term
First Claim
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1. An anti-thrombogenic chloroform soluble polymer compound where the PVP has a molecular weight of 10,000 to 360,000 and heparin has a normal molecular weight of 6,000 to 20,000 consisting essentially of a covalently bound poly-N-vinyl pyrrolidinone (PVP)-heparin formed by activating PVP with thionyl chloride to form an imidoyl ion and bonding heparin, said polymer compound being useful as a protracted i.v. therapeutic drug in humans.

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