Liposomes containing heparin and a process for obtaining them

• US 4,239,754 A
• Filed: 10/25/1977
• Issued: 12/16/1980
• Est. Priority Date: 10/23/1976
• Status: Expired due to Term

• Current Assignee: Choay SA
• Original Assignee: Choay SA
• Inventors: Sache, Edgar, Bertrand, Henri
• Primary Examiner(s): Brown, Johnnie R.
• Assistant Examiner(s): Hazel, Blondel
• Application Number:
  US05/845,106
• Time in Patent Office: 1,148 Days
• Field of Search: 424/180, 424/183, 424/315, 536/21
• US Class Current: 514/56
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 9/127 Liposomes
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

Heparin-based preparations wherein heparin is retained in or on liposomes.

The lipids of said liposomes are preferably phospholipids comprising acyl chains derived from non saturated fatty acids, advantageously essential acids.

These heparin-liposomes preparations have heparinic activity when administered in vivo by the oral route and a delayed-type action.

Claims

1. A method for the control of blood coagulability in vivo comprising orally adminstering in an amount effective to control blood coagulation a pharmaceutical composition comprising orally administrable heparin-liposomes, the lipids of which are formed of non-toxic physiologically acceptable and metabolizable phospholipids, with heparin retained therein or thereon in association with a pharmaceutical vehicle.

2. A method for the control of blood coagulability in vivo comprising orally administering in an amount effective to control blood coagulation a pharmaceutical composition comprising orally administrable heparin-liposomes, the lipids of which comprise lecithin, with heparin retained therein or thereon in association with a pharmaceutical vehicle.