Cell culture device
First Claim
1. A cell culture device comprising,a housing,a stationary spool mounted within and wholly surrounded by said housing,said housing and spool defining a fluid tight cavity therebetween,said housing having a port communicating with said cavity for introduction of cells into said cavity,said housing having inlet and outlet means,a semipermeable tube wrapped about said spool along the longitudinal axis thereof to form coils in said cavity,the ends of said tube extending through said inlet and outlet means,the interior of said tube defining a fluid flow path for communicating with a fluid source, andthe walls of said housing, spool, and tube defining an enclosed cell culture compartment,said tube being of a material capable of permitting transport, from said compartment to fluid flowing along said path, of products produced by said cells, and transport from said fluid to said compartment of nutrients for said cells, while maintaining immunological separation between said fluid and said cells.
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Accused Products
Abstract
A cell culture device for use, e.g., as an artificial pancreas, featuring, in various aspects, a semipermeable tube wrapped about a spool and mounted within a cylinder to form a cell culture compartment; an inlet and an outlet strand of the semipermeable tube being wrapped to form alternating adjacent coils to provide improved convective transport; and the semipermeable tube being wrapped to form helical coils to provide improved conductive transport.
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Citations
18 Claims
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1. A cell culture device comprising,
a housing, a stationary spool mounted within and wholly surrounded by said housing, said housing and spool defining a fluid tight cavity therebetween, said housing having a port communicating with said cavity for introduction of cells into said cavity, said housing having inlet and outlet means, a semipermeable tube wrapped about said spool along the longitudinal axis thereof to form coils in said cavity, the ends of said tube extending through said inlet and outlet means, the interior of said tube defining a fluid flow path for communicating with a fluid source, and the walls of said housing, spool, and tube defining an enclosed cell culture compartment, said tube being of a material capable of permitting transport, from said compartment to fluid flowing along said path, of products produced by said cells, and transport from said fluid to said compartment of nutrients for said cells, while maintaining immunological separation between said fluid and said cells.
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11. A cell culture device comprising,
a housing having a fluid tight cavity therein, said housing having a port communicating with said cavity for introduction of cells into said cavity, said housing having inlet and outlet means, a stationary semipermeable tube mounted in and wholly enclosed by said housing, said tube being curved about a transition region to form inlet and outlet portions extending between said region and said means, said inlet and outlet portions being wrapped within said cavity to form adjacent coils, with coils formed from said wrapped inlet portion alternating with coils formed from said wrapped outlet portion, the interior of said tube defining a fluid flow path for communicating with a fluid source, and the walls of said cavity and the exterior of said tube defining a cell culture compartment, said tube being of a material capable of permitting transport, from said compartment to fluid flowing along said path, of products produced by said cells, and transport from said fluid to said compartment of nutrients for said cells, while maintaining immunological separation between said fluid and said cells.
Specification
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Current AssigneeGeorg Panol, Peter D. Richardson, Pierre M. Galletti, William L. Chick
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Original AssigneeGeorg Panol, Peter D. Richardson, Pierre M. Galletti, William L. Chick
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InventorsChick, William L., Galletti, Pierre M., Panol, Georg, Richardson, Peter D.
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Primary Examiner(s)Warden, Robert J.
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Application NumberUS05/972,961Time in Patent Office735 DaysField of Search435/283, 435/284, 435/285, 435/286, 435/240, 435/241, 435/1, 435/2, 210/21, 210/321 R, 210/321 A, 210/497.1, 128/DIG. 3, 3/1US Class Current435/297.2CPC Class CodesA61M 1/1627 Dialyser of the inside perf...A61M 1/3472 with treatment of the filtrateA61M 1/3475 with filtrate treatment age...A61M 1/3489 by biological cells, e.g. b...C12M 23/06 Tubular C12M23/08, C12M23/1...C12M 29/04 Filters; Permeable or porou...C12M 29/10 PerfusionY10S 128/03 Heart-lungY10S 623/915 Method or apparatus for pre...
