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Apparatus and method for determining serum concentrates of metabolites by monitoring dialysate fluid

  • US 4,244,787 A
  • Filed: 06/11/1979
  • Issued: 01/13/1981
  • Est. Priority Date: 06/11/1979
  • Status: Expired due to Term
First Claim
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1. The method of determining the level of a predetermined metabolically important species in serum, without withdrawing blood or entering a sensor into the bloodstream, comprising the steps of:

  • diverting at least a portion of a dialysate effluent stream, obtained from equilibration with blood through a hemodialyzer, through a sampling apparatus, including an ion-specific electrode sensitive to a desired species;

    producing an electrode EMF proportional to the concentration of the sensed species; and

    converting the EMF to data indicating the dialysate concentrations of the species and determining the serum levels of the species from such data.

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