Artificial beta cell
First Claim
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1. An artificial beta cell comprising:
- blood analysis means for determining serial values of blood glucose concentration in the blood (BG) and including signal means for providing input signals corresponding to said values;
means coupled to the blood analysis means to receive said input signals and including, first means for deriving serial values of the rate of change of blood glucose concentration in the blood (BG), second means receiving said values of BG and deriving a difference factor (DF) in accordance with a function of BG which is monotonic and symmetrical in the first and third quadrants, and has a slope which is never negative and which is smaller adjacent the origin than it is remote from the origin, and third means receiving DF and adding corresponding values of DF and BG to give a projected blood glucose concentration (PBG), and fourth means for deriving a desired rate of insulin infusion (RI) using the derived value of PBG from a sigmoidal relationship between PBG and RI and providing an output signal corresponding to the desired value of RI; and
pump means coupled to receive the output signal and responsive to the output signal to supply the desired rate of insulin infusion to the subject.
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Abstract
An artificial beta cell regulates blood glucose concentration in a subject by continuously analyzing blood from the patient and deriving a computer output signal to drive a pump which infuses insulin at a rate corresponding to the signal. A value of blood glucose concentration from the analyzed blood is used by a computer to determine a rate of change of this concentration which in turn is used to derive a projected blood glucose level. A sigmoidal relationship between the projected blood glucose concentration and the rate of infusion is used to determine the actual rate of infusion required and hence an output signal is fed to the pump to create this actual rate of insulin infusion.
929 Citations
1 Claim
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1. An artificial beta cell comprising:
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blood analysis means for determining serial values of blood glucose concentration in the blood (BG) and including signal means for providing input signals corresponding to said values; means coupled to the blood analysis means to receive said input signals and including, first means for deriving serial values of the rate of change of blood glucose concentration in the blood (BG), second means receiving said values of BG and deriving a difference factor (DF) in accordance with a function of BG which is monotonic and symmetrical in the first and third quadrants, and has a slope which is never negative and which is smaller adjacent the origin than it is remote from the origin, and third means receiving DF and adding corresponding values of DF and BG to give a projected blood glucose concentration (PBG), and fourth means for deriving a desired rate of insulin infusion (RI) using the derived value of PBG from a sigmoidal relationship between PBG and RI and providing an output signal corresponding to the desired value of RI; and pump means coupled to receive the output signal and responsive to the output signal to supply the desired rate of insulin infusion to the subject.
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Specification
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Current AssigneeHospital For SICK Children
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Original AssigneeHospital For SICK Children
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InventorsAlbisser, Anthony M., Leibel, Bernard S.
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Primary Examiner(s)Kamm, William E.
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Application NumberUS06/011,601Time in Patent Office708 DaysField of Search128/635, 128/637, 128/213 R, 128/214 E, 128/214 F, 128/260US Class Current604/66CPC Class CodesA61B 5/14865 invasive, e.g. introduced i...A61M 5/1723 using feedback of body para...
