C-5 Substituted uracil nucleosides
First Claim
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1. A compound of the formula:
- ##STR7## wherein Ro is --CH═
CH--CH3 or --CH═
CH--CF3 and R is β
-D-ribofuranosyl, β
-D-2-deoxyribofuranosyl or β
-D-arabinofuranosyl.
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Abstract
Compounds of the formula ##STR1## wherein Ro is --CH═CH--CH3 or --CH═CH--CF3 and R is β-D-ribofuranosyl, β-D-2-deoxyribofuranosyl or β-D-arabinofuranosyl are useful as antiviral agents.
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Citations
7 Claims
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1. A compound of the formula:
- ##STR7## wherein Ro is --CH═
CH--CH3 or --CH═
CH--CF3 and R is β
-D-ribofuranosyl, β
-D-2-deoxyribofuranosyl or β
-D-arabinofuranosyl. - View Dependent Claims (2, 3, 4, 5)
- ##STR7## wherein Ro is --CH═
-
6. A composition useful for treating HSV-1 virus infections in mammals which comprises an effective amount of compound of the formula ##STR8## wherein Ro is CH═
- CH--CH3 or --CH═
CH--CF3 and R is β
-D-ribofuranosyl, β
-D-2-deoxyribofuranosyl or β
-D-arabinofuranosyl.
- CH--CH3 or --CH═
-
7. A method of treating a HSV-1 virus infection in a host mammal afflicted with such infection which comprises administering to said host an effective amount of the compound of the formula ##STR9## wherein Ro is --CH═
- CH--CH3 or --CH═
CH--CF3 and R is β
-D-ribofuranosyl, β
-D-2-deoxyribofuranosyl or β
-D-arabinofuranosyl.
- CH--CH3 or --CH═
Specification
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Current AssigneeRegents of the University of California (University of California)
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Original AssigneeRegents of the University of California (University of California)
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InventorsBergstrom, Donald E., Ruth, Jerry L.
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Primary Examiner(s)Brown, Johnnie R.
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Assistant Examiner(s)Hazel, Blondel
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Application NumberUS06/053,925Time in Patent Office575 DaysField of Search536/23, 424/180US Class Current514/50CPC Class CodesC07H 19/06 Pyrimidine radicals
