L-Cysteine derivatives and medicaments containing them

• US 4,248,890 A
• Filed: 06/05/1979
• Issued: 02/03/1981
• Est. Priority Date: 06/22/1978
• Status: Expired due to Term

• Current Assignee: Parcor
• Original Assignee: Parcor
• Inventors: Maffrand, Jean-Pierre
• Primary Examiner(s): Trousof, Natalie
• Assistant Examiner(s): SHIPPEN, MICHAEL L
• Application Number:
  US06/045,771
• Time in Patent Office: 609 Days
• Field of Search: 424/309, 424/319, 560/18, 562/432
• US Class Current: 514/533
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: C07C 323/58 with amino groups bound to the carbon skeleton

Abstract

L-cysteine derivatives of formula ##STR1## in which R is a lower alkoxycarbonyl or carboxy group, and salts thereof. The compounds have been found to have a mucolytic activity and low toxicity. Processes for the preparation of the compounds and medicaments containing them are described and exemplified.

Claims

1. L-cysteine compound of the formula ##STR5## in which R is lower alkoxycarbonyl or carboxy or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1, which is S-(o-methoxycarbonylbenzyl) cysteine.

3. The compound of claim 1, which is S-(o-carboxybenzyl) cysteine.

4. The compound of claim 1, which is S-(m-carboxybenzyl) cysteine.

5. The compound of claim 1, which is S-(p-carboxybenzyl) cysteine.

6. A mucolytic medicament comprising a pharmaceutically acceptable carrier and an effective amount of the compound of claim 1.

7. The medicament of claim 6 wherein said compound is present in an amount of 2 and 5 percent by weight.

8. A unit dose of the medicament of claim 6 containing 0.050 to 1.0 g of said compound.

9. The medicament of claim 6 wherein said compound is S-(o-methoxycarbonylbenzyl) cysteine.

10. The medicament of claim 6 wherein said compound is S-(o-carboxybenzyl) cysteine.

11. The medicament of claim 6 wherein said compound is S-(m-carboxybenzyl) cysteine.

12. The medicament of claim 6 wherein said compound is S-(p-carboxybenzyl) cysteine.

13. A process for facilitating expectoration, for clearing the respiratory tract, for reestablishing the physiological secretion of mucus and for protecting the respiratory tract comprising administering an effective amount of the medicament of claim 6.