Method and apparatus suitable for ocular blood flow analysis

• US 4,249,825 A
• Filed: 05/14/1979
• Issued: 02/10/1981
• Est. Priority Date: 05/14/1979
• Status: Expired due to Term

• Current Assignee: Trustees of Boston University
• Original Assignee: Trustees of Boston University
• Inventors: Shapiro, Jerrold M.
• Primary Examiner(s): Corbin, John K.
• Assistant Examiner(s): Arnold, Bruce Y.
• Application Number:
  US06/038,610
• Time in Patent Office: 638 Days
• Field of Search: 356/223, 354/20, 128/654, 128/745
• US Class Current: 356/223
• CPC Class Codes: A61B 3/1241 specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
• CPC Class Codes: A61B 5/0275 using tracers, e.g. dye dilution
• CPC Class Codes: G01N 21/86 Investigating moving sheets G01N21/89 takes precedence

Abstract

Glaucoma and other diseases may be detected by the analysis of angiograms to determine ocular blood flow. Using rapid sequence photography an ocular image is recorded on successive film frames. To determine the optical density of the film at selected image sites, the image position on the frames being subject to change from frame to frame, each frame is initially positioned manually at a starting position relative to a density sensing system. Then, X-Y stepping motors move the film under control of a digital processor to position the film frame at each selected image site. A detector is insensitive to light from a viewing optical system because of a filter included in that system. A crosshair image-point indicator is included on a filter in the viewing system.

Claims

1. A film analysis system for determining the optical density of an image on successive film frames at the same preselected image sites, the image position on the frames being subject to change from frame to frame, the system comprising:

a film carrier;

a sensing optical system for illuminating a film on the carrier and for projecting the light from an illuminated point onto a photodetector;

drive means for providing relative movement between the sensing optical system and the film carrier to illuminate selected points on the film; and

drive control means, including a control data memory, for controlling automatic relative movement of the sensing optical system and the film carrier from an initial film position to subsequent positions in accordance with stored position control data to successively illuminate preselected image sites.

2. A film analysis system as claimed in claim 1 wherein the drive conrol means also controls a short scanning movement between the sensing optical system and the film carrier at each image site.

3. A film analysis system as claimed in claim 2 further comprising a data memory for storing minimum or maximum values of the photodetector output during scans.

4. A film analysis system as claimed in claim 1 wherein the drive means provides for rectilinear movement in orthogonal X and Y directions.

5. A film analysis system as claimed in claim 4 wherein the drive means includes X and Y stepping motors.

6. A film analysis system as claimed in claim 5 wherein the drive control means further comprises manual control for positioning the film carrier at an initial position.

7. A film analysis system as claimed in claim 1 wherein the drive control means includes a digital processor.

8. A film analysis system as claimed in claim 1 wherein the photodetector detects a passband of light frequencies and further comprising:

a viewer optical system for illuminating the image on the film and for directing the image illuminating light from the film to the viewer, the viewer optical system including an optical filter ahead of the film for filtering a stopband of frequencies from the image illuminating light, the stopband coinciding with the photodetector passband.

10. A film analysis system as claimed in claim 8 or 9 wherein the viewer optical system includes an image point indicator.

11. An film analysis system as claimed in claim 10 wherein the image point indicator is a pair of crosshairs on the optical filter.

9. A film analysis system for viewing an image on a film while determining the optical density of an image point comprising:

a detector for detecting a passband of light frequencies;

a viewer for viewing the image on the film;

a sensing optical system for illuminating the image point on the film and for directing the point illuminating light from the image point to the detector;

a viewer optical system for illuminating the image on the film and for directing the image illuminating light from the film to the viewer, the viewer optical system including an optical filter ahead of the film for filtering a stopband of frequencies from the image illuminating light, the stopband coinciding with the detector passband.

12. A method of determining the optical density of a recorded image at preselected image sites for successive instants in time comprising:

providing a plurality of image frames, each taken as a known instant in time;

positioning each image frame relative to a density sensing system at a predetermined starting position of the image;

moving each image frame and the density sensing system relative to each other under electronic control to predetermined image sites in accordance with stored position control data; and

sensing the image density at each image site.

13. A method of determining the optical density of a recorded image as claimed in claim 12 wherein the image is recorded on film.

14. A method of determining the optical density of a recorded image as claimed in claim 12 further comprising the step of moving each image frame and the density sensing system relative to each other in a short scan at each of the image sites.

15. A method of determining the optical density of a recorded image as claimed in claim 14 further comprising the step of selecting the minimum or maximum image density during the scan at an image site.

16. A method of determining the optical density of a recorded image as claimed in claim 12 wherein each image frame is positioned relative to the density sensing system at the starting position under manual control.

17. A method of determining the optical density of a recorded image as claimed in claim 12 wherein the electronic control is provided by a digital processor.