Oxygen-transferable fluorocarbon emulsion
First Claim
1. A stable emulsion in a physiologically acceptable aqueous medium of an oxygen-transferrable perfluorocarbon compound having a particle size of about 0.05 to 0.3μ
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2.0 to 5.0% (w/v) in the amount of a high molecular weight nonionic surfactant which is a polyoxyethylene-polyoxypropylene copolymer having a molecular weight of 2,000 to 20,000;
0.1 to 1.0% (w/v) in the amount of a phospholipid; and
0.004 to 0.1% (w/v) in the amount of at least one fatty acid compound selected from the group consisting of fatty acids having 8 to 22 carbon atoms, physiologically acceptable salts and monoglycerides thereof;
the proportion of the said perfluorocarbon compound (A) and the said perfluoro tert-amine (B) being 95-50 to 5-50 by weight.
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Abstract
50-95 Parts by weight of a perfluorocarbon compound such as perfluorodecalin, perfluoromethyldecalin, perfluoro alkylcyclohexanes having 3 to 5 carbon atoms in the alkyl, perfluoro alkyltetrahydrofurans having 5 to 7 carbon atoms in the alkyl, perfluoro alkyltetrahydropyrans having 4 to 6 carbon atoms in the alkyl, perfluoroalkanes having 9 to 11 carbon atoms, and 50-5 parts by weight of a perfluoro tert.-amine such as perfluoro tert.-alkylamines having 9-11 carbon atoms, perfluoro N-alkylpiperidines having 4 to 6 carbon atoms in the alkyl, and perfluoro N-alkylmorpholines having 5 to 7 carbon atoms in the alkyl are emulsified in an aqueous medium by the aid of a high-molecular-weight nonionic surfactant have a molecular weight of about 2,000 to 20,000, and phospholipids as emulsifying agent, and fatty acids having 8 to 22 carbon atoms or salts or monoglycerides thereof as emulsifying adjuvant.
The resulting oxygen-transferable emulsion having a particle size of 0.05 to 0.25μ is very stable for a long period of time, can be mixed with plasma extenders, and retains for long time in the blood stream of animals when it is used as an artificial blood substitute while being excreted very rapidly.
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Citations
20 Claims
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1. A stable emulsion in a physiologically acceptable aqueous medium of an oxygen-transferrable perfluorocarbon compound having a particle size of about 0.05 to 0.3μ
- , which comprises 10 to 50% (w/v) in the sum of the amount of (A) perfluorodecalin and (B) perfluoro tripropylamine;
2.0 to 5.0% (w/v) in the amount of a high molecular weight nonionic surfactant which is a polyoxyethylene-polyoxypropylene copolymer having a molecular weight of 2,000 to 20,000;
0.1 to 1.0% (w/v) in the amount of a phospholipid; and
0.004 to 0.1% (w/v) in the amount of at least one fatty acid compound selected from the group consisting of fatty acids having 8 to 22 carbon atoms, physiologically acceptable salts and monoglycerides thereof;
the proportion of the said perfluorocarbon compound (A) and the said perfluoro tert-amine (B) being 95-50 to 5-50 by weight. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16, 17, 18, 19, 20)
- , which comprises 10 to 50% (w/v) in the sum of the amount of (A) perfluorodecalin and (B) perfluoro tripropylamine;
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11. The emulsion according to claim 30, wherein the plasma expander is hydroxyethyl starch or modified gelatin or dextran.
Specification
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- Resources
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Current AssigneeGreen Cross Corporation (Green Cross Holdings Corporation)
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Original AssigneeGreen Cross Corporation (Green Cross Holdings Corporation)
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InventorsYamanouchi, Kouichi, Yokoyama, Kazumasa, Murashima, Ryoichiro, Tsuda, Yoshio
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Primary Examiner(s)Waddell, Frederick E.
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Application NumberUS06/041,794Time in Patent Office643 DaysField of Search424/366, 424/352US Class Current514/776CPC Class CodesA61K 9/0026 Blood substitute; Oxygen tr...
