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Oxygen-transferable fluorocarbon emulsion

  • US 4,252,827 A
  • Filed: 05/23/1979
  • Issued: 02/24/1981
  • Est. Priority Date: 05/23/1979
  • Status: Expired due to Term
First Claim
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1. A stable emulsion in a physiologically acceptable aqueous medium of an oxygen-transferrable perfluorocarbon compound having a particle size of about 0.05 to 0.3μ

  • , which comprises 10 to 50% (w/v) in the sum of the amount of (A) perfluorodecalin and (B) perfluoro tripropylamine;

    2.0 to 5.0% (w/v) in the amount of a high molecular weight nonionic surfactant which is a polyoxyethylene-polyoxypropylene copolymer having a molecular weight of 2,000 to 20,000;

    0.1 to 1.0% (w/v) in the amount of a phospholipid; and

    0.004 to 0.1% (w/v) in the amount of at least one fatty acid compound selected from the group consisting of fatty acids having 8 to 22 carbon atoms, physiologically acceptable salts and monoglycerides thereof;

    the proportion of the said perfluorocarbon compound (A) and the said perfluoro tert-amine (B) being 95-50 to 5-50 by weight.

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