Structural configuration for transport of a liquid drop through an ingress aperture

• US 4,254,083 A
• Filed: 07/23/1979
• Issued: 03/03/1981
• Est. Priority Date: 07/23/1979
• Status: Expired due to Term

• Current Assignee: Clinical Diagnostic Systems Inc.
• Original Assignee: Eastman Kodak Company
• Inventors: Columbus, Richard L.
• Primary Examiner(s): Turk, Arnold
• Application Number:
  US06/059,924
• Time in Patent Office: 589 Days
• Field of Search: 422/55-58, 422/68, 422/99, 422/100, 435/4, 435/310, 23/230 R, 23/230 B, 356/244
• US Class Current: 422/401
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 3/50273 characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043
• CPC Class Codes: B01L 3/502746 characterised by the means for controlling flow resistance, e.g. flow controllers, baffles B01L3/502738 takes precedence
• CPC Class Codes: Y10T 436/146666 Bile pigment
• CPC Class Codes: Y10T 436/171538 Urea or blood urea nitrogen

Abstract

A device is disclosed that includes an ingress aperture which provides improved transport of a drop of liquid, from an exterior surface of the device to the device interior. Means are provided at the intersection of the aperture sidewall and the exterior surface for urging a drop deposited thereon to move into contact with the aperture sidewall and thus into the aperture.

Claims

1. In a liquid transport device comprising an exterior, drop-receiving surface, means interior of said surface for transporting the liquid through a zone, and an ingress aperture comprising an internal sidewall fluidly connecting said surface and said interior transporting means,

the improvement wherein at least the intersection of said exterior surface and said sidewall includes at a predetermined location, means for substantially urging a portion of a drop of liquid deposited thereon to move into contact with said sidewall, said urging means including a surface configuration capable of forming a compound meniscus on a contacting liquid drop.

2. A device as defined in claim 1, wherein said surface configuration comprises an interior corner in the aperture sidewall at at least said exterior surface.

3. A device as defined in claim 1, wherein said intersection includes from 3 to about 10 of said urging means at spaced-apart locations.

4. A device as defined in claim 1, wherein said aperture has six of said urging means.

5. A device as defined in claim 1, wherein said transporting means includes two spaced-apart opposed surfaces at least one of which includes an absorbent layer containing at least one reagent capable of producing a radiometrically detectable signal when contacted by the liquid of the drop.

16. A device as defined in claim 1, 7 or 12, wherein the liquid is a biological liquid.

17. A device as defined in claim 16, wherein said liquid is blood serum.

18. A device as defined in claim 1 or 6, wherein said transporting means comprises opposing surfaces of first and second wall members, spaced apart a distance effective to induce capillary flow of liquid introduced into said zone.

6. In a liquid transport device comprising an exterior surface, means interior of said surface for transporting the liquid through a zone, and an ingress aperture comprising an internal sidewall fluidly connecting said surface and said interior transporting means,

the improvement wherein aperture has a transverse cross-sectional shape of a regular hexagon.

7. In a liquid transport device comprising an exterior surface, a capillary transport zone interior of said surface formed by interior, capillary-spaced surfaces of first and second wall members, one of said wall members including a liquid ingress aperture comprising a sidewall extending from said exterior surface to said transport zone,

the improvement wherein at least the intersection of said exterior surface and said sidewall includes at a predetermined location, means for substantially urging liquid deposited on said surface to move into contact with said sidewall, said means including an interior corner in the aperture sidewall at at least said exterior surface.

8. A device as defined in claim 7, wherein said urging means comprises a plurality of predetermined, spaced-apart interior corners numbering from 3 to about 10.

9. A device as defined in claim 7, wherein said urging means comprises six generally equidistantly spaced interior corners in said aperture.

10. A device as defined in claim 7, wherein said urging means comprises said aperture having a transverse cross-sectional shape of a regular hexagon.

11. A device as defined in claim 7, wherein one of said interior surfaces includes an absorbent layer containing at least one reagent capable of producing a radiometrically detectable signal when contacted by the liquid of the drop.

12. In a liquid transport device comprising an exterior, drop-receiving surface, a capillary transport zone interior of said surface formed by interior, capillary-spaced surfaces of first and second members, one of said members including an ingress aperture extending from said exterior surface to said transport zone,

the improvement wherein said aperture comprises from 3 to about 10 distinct sidewalls extending between said exterior surface and said interior surface of said one member, and intersecting to define from 3 to about 10 interior corners.

13. A device as defined in claim 12, wherein said aperture has six corners defined by six intersecting sidewalls.

14. A device as defined in claim 12, wherein said aperture has a transverse cross-sectional shape of a regular hexagon.

15. A device as defined in claim 12, wherein said other member interior surface is the exposed surface of an absorbent layer containing at least one reagent capable of producing a radiometrically detectable signal when contacted by the liquid.

19. A test device for radiometric detection of an analyte of a liquid, comprising

a support,

a cover member spaced away from the support,

one or more layers disposed sequentially on the support and containing at least one reagent composition in at least one of said layers, said composition being capable of producing a radiometrically detectable signal that is proportional to the quantity of the analyte,

means for sealing said layers between said support and said cover member with a capillary space between the outermost one of said layers and said cover member, said space being effective to provide capillary flow of liquid between said cover member and said outermost layer,

said cover member including a liquid ingress aperture and an air vent aperture spaced away from said access aperture,

said ingress aperture having a sidewall extending through said cover member and comprising six surfaces intersecting to form six corners,

whereby liquid placed in contact with said cover member at said ingress aperture is urged by said corners to enter the aperture and said capillary space.