Control of mastitis and compositions therefor

• US 4,258,056 A
• Filed: 04/19/1979
• Issued: 03/24/1981
• Est. Priority Date: 12/18/1978
• Status: Expired due to Term

• Current Assignee: Economics Laboratory Inc (Ecolab, Inc.)
• Original Assignee: Economics Laboratory Inc (Ecolab, Inc.)
• Inventors: Lentsch, Steven E.
• Primary Examiner(s): Phillips, Delbert R.
• Application Number:
  US06/031,429
• Time in Patent Office: 705 Days
• Field of Search: 424/303, 424/309
• US Class Current: 514/566
• CPC Class Codes: A61K 31/195 having an amino group

Abstract

Neutral to mildly acidic externally-applied mastitis control agents comparable to iodophor teat dips in activity can be obtained from the combination of an anionic surfactant (e.g. an aromatic sulfonate or sulfonic acid) and an aminocarboxylic-type chelating agent. A nitroalkanol antibacterial can be included in the composition. The full strength teat dip contains a major amount of water (but less than 98%) and typically includes an emollient, a buffering agent, and a thickener. The anionic surfactant (which is believed to be effective against gram positive mastitis-causing organisms) and the chelating agent appear to cooperate in the pH range above 4 and below 7. The chelating agent is believed to improve the cell wall permeability of the mastitis-causing organisms, even in this pH range.

Claims

1. A method for killing mastitis-causing organisms on an animal'"'"'s teats, wherein control over the organisms can be obtained in less than 15 minutes, said method comprising the step of treating the teats of the animal with a composition containing a major amount of water, having a pH above 4 and below 6.5 at 23°

C., and consisting essentially of;

(a) at least about 0.1% by weight of an aminocarboxylic acid or aminocarboxylate chelating agent having a calcium chelate stability constant of at least about 6;

(b) at least 0.5% by weight of an anionic surfactant uniformly distributable in water and having the general formula

space="preserve" listing-type="equation">LSO.sub.x.sup.⊖

N.sup.⊕

wherein L is organic, x is 3 or 4, and N.sup.⊕

is a topically acceptable cation; and

(c) up to about 98% by weight of an aqueous diluent;

said components (a) and (b) being uniformly distributed through said aqueous diluent.

2. A method according to claim 1 wherein said chelating agent is selected from the topically acceptable salts of a nitrilopolyacetic acid selected from the group consisting of EDTA, CDTA, HEDTA, and NTA.

3. A method according to claim 1 wherein said chelating agent comprises an ethylenediaminetetraacetate of the formula H_m⁺ M_4-m⁺ EDTA^-4, wherein

EDTA^-4 represents the ethylenediaminetetraacetate anion,

M⁺ represents a topically acceptable cation, and

m represents an integer from 0 to 3.

4. A method according to claim 3 wherein said M⁺ is an alkali metal cation.

5. A method according to claim 4 wherein said ethylenediaminetetraacetate comprises the disodium salt of ethylenediaminetetraacetic acid.

6. A method according to claim 2 wherein said composition comprises 80-92% by weight of water, said carboxylate salt being dissolved in said water.

7. A method according to claim 2 further comprising a buffering agent to stabilize the pH of said composition at about 5, and an effective amount of an emollient.

8. A method according to claim 1 wherein said anionic surfactant is selected from the group consisting of linear alkylbenzene sulfonic acid and its topically acceptable salts.

9. A method according to claim 1, wherein said composition is a teat dip further comprising:

(d) 0.1 to about 10% by weight of emollient;

(e) a thickening amount of a water-thickening agent; and

(f) a buffering amount of a buffer, sufficient to provide a buffered pH in the said pH range.

10. A method according to claim 1 wherein said treating comprises the step of dipping the teats in a reservoir of said composition.

11. A method according to claim 9, wherein said treating comprises the step of dipping the teats in a reservoir of said composition.

12. A method according to claim 1, wherein said composition consists essentially of:

disodium or tetrasodium ethylenediaminetetraacetate in an amount of about 1.0 to about 2.0% by weight;

C₉ to C₁₈ -linear alkyl-benzene sulfonate in an amount of from 0.5 to 3.5% by weight;

glycerine in an amount of 0.1 to 10% by weight;

a cellulosic thickener in an amount of more than 0.1% but less than 20% by weight;

water in an amount of from about 80 to about 92% by weight;

a citric acid--citrate buffer in an amount sufficient to stabilize said pH; and

14. A method according to claim 1 comprising the step of spraying the teats of the animal with the said composition.

13. - 0. 4 by weight of colorants, odorants, and any additional surfactants.