Method of reducing the number of microorganisms in a media and a method of preservation
First Claim
1. A method of reducing the number of viable bacteria, fungi, algae and yeast in media by physically contacting the bacteria, fungi, algae and yeast with a surface which has been altered in a manner which comprises contacting a substrate, which develops a negative charge in water, with an amount effective to inhibit the growth of said microorganisms of a substance that ionizes in water to form cations and anions which substance is selected from the group consisting of sulfonium salts of the formula R8 R9 R10 S+ X-, sulfonium salts of the formula ##STR6## isothiuronium salts of the formula RSC(NH2)2+ X-, isothiuronium salts of the formula ##STR7## phosphonium salts of the formula R4 R5 R6 R7 P+ X-, and phosphonium salts of the formula ##STR8## wherein R8, R9 and R10 are independently alkyl groups or aralkyl groups wherein there is a total of less than 30 carbon atoms in the molecule or a silylsubstituted alkyl radical of the formula ##STR9## where Y is a hydrolyzable group, Q is an alkyl radical of 1 or 2 carbon atoms or (CH3)3 SiO, a has an average value of 0-3, b has an average value of 0-3, n is an integer of 1 or greater and X- is a water soluble monovalent anion, R is independently alkyl or aralkyl groups wherein there is a total of less than 20 carbon atoms in the molecule or a silylsubstituted alkyl radical of the formula ##STR10## as defined above, R4, R5, R6 and R7 are as defined above for R8, R9 and R10 ;
- R11 and R12 are independently alkyl groups or aralkyl groups wherein there is a total of less than 60 carbon atoms in the molecule and d is an integer of 1 or greater.
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Abstract
What is disclosed is a method of reducing microorganisms by contacting the microorganisms with the surface of a substrate which has been altered by contacting a substrate which develops a negative charge in water with a substance that ionizes in water to form cations and anions, which cations absorb to the substrate by a process of ion exchange in which protons are replaced by the cations of the ionizing substance. The altered surfaces can include hospital sheeting, clothing and a wide variety of surfaces which come into contact with microorganisms.
60 Citations
26 Claims
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1. A method of reducing the number of viable bacteria, fungi, algae and yeast in media by physically contacting the bacteria, fungi, algae and yeast with a surface which has been altered in a manner which comprises contacting a substrate, which develops a negative charge in water, with an amount effective to inhibit the growth of said microorganisms of a substance that ionizes in water to form cations and anions which substance is selected from the group consisting of sulfonium salts of the formula R8 R9 R10 S+ X-, sulfonium salts of the formula ##STR6## isothiuronium salts of the formula RSC(NH2)2+ X-, isothiuronium salts of the formula ##STR7## phosphonium salts of the formula R4 R5 R6 R7 P+ X-, and phosphonium salts of the formula ##STR8## wherein R8, R9 and R10 are independently alkyl groups or aralkyl groups wherein there is a total of less than 30 carbon atoms in the molecule or a silylsubstituted alkyl radical of the formula ##STR9## where Y is a hydrolyzable group, Q is an alkyl radical of 1 or 2 carbon atoms or (CH3)3 SiO, a has an average value of 0-3, b has an average value of 0-3, n is an integer of 1 or greater and X- is a water soluble monovalent anion, R is independently alkyl or aralkyl groups wherein there is a total of less than 20 carbon atoms in the molecule or a silylsubstituted alkyl radical of the formula ##STR10## as defined above, R4, R5, R6 and R7 are as defined above for R8, R9 and R10 ;
- R11 and R12 are independently alkyl groups or aralkyl groups wherein there is a total of less than 60 carbon atoms in the molecule and d is an integer of 1 or greater.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A method of reducing the number of viable bacterial, fungi, algae and yeast in media by physically contacting the bacteria, fungi, algae and yeast with a surface which has been altered in a manner which comprises contacting a substrate, which develops a negative charge in water, with an amount effective to inhibit the growth of said microorganism of a substance that ionizes in water to form cations and anions which substance consists of an organic amine of the formula ##STR11## in which d in each case is an integer of 1 or greater.
Specification