Method of determining pressure within liquid containing vessel

• US 4,265,251 A
• Filed: 06/28/1979
• Issued: 05/05/1981
• Est. Priority Date: 06/28/1979
• Status: Expired due to Term

• Current Assignee: Schering Ag (Merck & Co., Inc.)
• Original Assignee: Rasor Associates, Inc.
• Inventors: Tickner, Ernest G.
• Primary Examiner(s): Michell, Robert W.
• Assistant Examiner(s): Jaworski, Francis J.
• Application Number:
  US06/052,745
• Time in Patent Office: 677 Days
• Field of Search: 128/661-663, 128/672-673, 128/660, 73/703, 73/700, 73/861.25
• US Class Current: 600/438
• CPC Class Codes: A61B 2017/22089 Gas-bubbles
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 8/04 Measuring blood pressure
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61K 49/223 Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
• CPC Class Codes: G01F 1/66 by measuring frequency, phase shift or propagation time of electromagnetic or other waves, e.g. using ultrasonic flowmeters
• CPC Class Codes: G01F 1/704 using marked regions or existing inhomogeneities within the fluid stream, e.g. statistically occurring variations in a fluid parameter G01F1/76, G01F25/00 take precedence
• CPC Class Codes: G01L 11/04 by acoustic means

Abstract

Pressure within a liquid containing vessel is determined by adding a solid precursor for at least one bubble to the liquid, retaining the precursor in the liquid for a sufficient time for it to form at least one bubble and generate a sonic signal, metering a characteristic of the sonic signal which is representative of the pressure in the liquid and determining the pressure in the liquid from the measured characteristic.

Claims

1. A method of determining pressure within a liquid containing vessel, comprising:

adding a solid microbubble precursor to said liquid;

retaining said precursor in said liquid for sufficient time to form a plurality of microbubbles thereby generating a plurality of sonic signals, said precursor forming said plurality of microbubbles at a plurality of times, wherein said precursor is formed to provide each of said microbubbles of a substantially equal selected size, said size being selected to be within a range from about 0.5 micron to about 325 microns;

measuring a characteristic of said sonic signals representative of the pressure in the liquid, said measuring being of the ultrasonic frequency generated by formation of said microbubbles as a function of said times; and

determining the pressure in the liquid from the measured characteristic, said determining being of the pressure in the liquid as a function of time.

2. A method as in claim 1, wherein said vessel is a cardiovascular system of a living being.

3. A method as in claim 1, wherein said vessel is a cardiovascular system of living test subject and said determined pressure include the systolic and the diastolic pressures of the living being.

4. A method as in claim 1, wherein said solid bubble precursor comprises at least one particle having a hollow space completely enclosed therein, said space being filled with a gas at a pressure above the pressure in said vessel, wherein said retaining is for a time sufficient to dissolve sufficient of said particles to allow said gas to escape from said hollow space and alternately expand and contract under the lesser pressure in said vessel towards an equilibrium bubble size and shape at said lesser pressure, and wherein said sonic signal is generated by said alternate expansion and contraction.

5. A method as in claim 1, wherein said particle is formulated of saccharide materials.

6. A method as in claim 5, wherein said vessel is a cardiovascular system of a living test subject and said determined pressure include the systolic and diastolic pressures of said living being.

7. A method of obtaining the substantially instantaneous volumetric flow rate in a cardiovascular system of a living being, comprising:

adding a solid microbubble precursor to said system;

retaining said precursor in said system for sufficient time to form a plurality of microbubbles and thereby generate a plurality of ultrasonic signals opposite a location in said system, each of said microbubbles being of a size within a range from about 0.5 micron to about 325 microns;

obtaining an ultrasonic image representative of said ultrasonic signal, said image simultaneously providing a measurement of both the positions and velocities of said microbubbles opposite said location; and

determining the substantially instantaneous volumetric flow rate at said location from said image.

8. A method as in claim 7, wherein said microbubbles are of generally a uniform size.

9. A method of enhancing ultrasonic echographic imaging in a liquid enclosed in a vessel by increasing image contrast, comprising:

adding a solid microbubble precursor to said liquid;

retaining said precursor in said vessel for sufficient time to form a plurality of microbubbles in said liquid, each of said microbubbles being of a size within a range from about 0.5 micron to about 325 microns; and

obtaining an enhanced ultrasonic echographic image of said liquid opposite a position therein containing said microbubbles by increasing the relative contrast between said liquid and said vessel.