Matansinol 3-n-hexadecanoate

• US 4,265,814 A
• Filed: 03/19/1979
• Issued: 05/05/1981
• Est. Priority Date: 03/24/1978
• Status: Expired due to Term

• Current Assignee: Takeda Chemical Industries, Ltd. (Takeda Pharmaceutical Company Limited)
• Original Assignee: Takeda Chemical Industries, Ltd. (Takeda Pharmaceutical Company Limited)
• Inventors: Hashimoto, Naoto, Kishi, Toyokazu
• Primary Examiner(s): BOND, ROBERT
• Application Number:
  US06/021,702
• Time in Patent Office: 778 Days
• Field of Search: 260/239.3 P
• US Class Current: 540/462
• CPC Class Codes: C07D 498/14 Ortho-condensed systems

Abstract

Maytansinoids of the formula: ##STR1## wherein R is hydrogen or alkyl of 1 to 15 carbon atoms are produced by contacting, in the presence of a carbodiimide, maytansinol with a carboxylic acid of the formula:

R--COOH

wherein R has the same meaning as defined above.

In accordance with a second aspect of the invention there are provided novel maytansinoids of the formula ##STR2## wherein R'"'"' is hydrogen, n-butyl or alkyl of 5 to 15 carbon atoms.

Claims

1. A maytansinoid of the formula:

##STR6##