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Method of delivering drug with aid of effervescent activity generated in environment of use

  • US 4,265,874 A
  • Filed: 04/25/1980
  • Issued: 05/05/1981
  • Est. Priority Date: 04/25/1980
  • Status: Expired due to Term
First Claim
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1. An osmotic device for delivering a drug to an environment of use, said device comprising:

  • (a) a shaped laminated wall comprising a lamina formed of a semi-permeable material and a lamina formed of a microporous material, said wall permeable to the passage of an external fluid present in the environment of use and substantially impermeable to the passage of drug, the wall surrounding and forming;

    (b) a compartment containing the drug indomethacin which exhibits a limited solubility in the fluid, and a pharmaceutically acceptable compound selected from the group consisting of carbonates, bicarbonates and mixtures thereof, which compounds are capable of reactively effervescing with fluid present in the environment of use; and

    ,(c) a passageway in the wall connecting the compartment and the exterior of the device for delivering (1) the drug in a therapeutically effective amount to the envirionment, and (2) the compound which reacts with fluid in the environment and effervesces, and thereby aids in delivering the drug to the environment over a prolonged period of time.

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