Biological materials

• US 4,269,821 A
• Filed: 05/02/1980
• Issued: 05/26/1981
• Est. Priority Date: 03/20/1975
• Status: Expired due to Term

• Current Assignee: Jorg Kreuter, Speiser; Peter Paul
• Original Assignee: Jorg Kreuter, Speiser; Peter Paul
• Inventors: Kreuter, Jorg, Speiser, Peter P.
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US06/146,018
• Time in Patent Office: 389 Days
• Field of Search: 427/1, 252/316, 424/16, 424/32, 424/33, 424/81, 424/88, 424/89, 424/92
• US Class Current: 424/489
• CPC Class Codes: A61K 2039/6093 Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
• CPC Class Codes: A61K 2039/622 non-covalent binding
• CPC Class Codes: A61K 39/385 Haptens or antigens, bound to carriers
• CPC Class Codes: A61K 41/17 by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
• CPC Class Codes: C12N 11/04 entrapped within the carrier, e.g. gel or hollow fibres
• CPC Class Codes: C12N 11/082 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: C12N 11/087 Acrylic polymers
• CPC Class Codes: C12N 11/098 formed in the presence of the enzymes or microbial cells
• CPC Class Codes: Y10S 977/795 Composed of biological material
• CPC Class Codes: Y10S 977/897 Polymerization
• CPC Class Codes: Y10S 977/898 Enzymatic
• CPC Class Codes: Y10S 977/915 Therapeutic or pharmaceutical composition
• CPC Class Codes: Y10S 977/917 Vaccine
• CPC Class Codes: Y10S 977/918 Immunological

Abstract

There are described processes for the preparation of submicroscopic particles of physiologically acceptable polymer associated with a biologically active material, by polymerizing a monomer in the presence of the biologically active material or by adsorbing the biologically active material upon preformed submicroscopic polymer particles. Where the biologically active material is an antigen, the particles are useful as constituents of injectable vaccines having an adjuvant effect.

Claims

1. Submicroscopic particles of a polymerized styrene or acrylic monomer on which is absorbed insulin, in suspension or colloidal solution in a sterile aqueous medium, wherein the submicroscopic particles have a particle size of from 50 to 500 nm diameters, whereby the submicroscopic particles are formed by suspending the polymeric particles in a liquid medium containing the insulin.

2. A method of injecting insulin particles according to claim 1.