Selective chemical sensitive field effect transistor transducers

• US 4,273,636 A
• Filed: 05/19/1978
• Issued: 06/16/1981
• Est. Priority Date: 05/26/1977
• Status: Expired due to Term

• Current Assignee: Nihon Kohden Corporation
• Original Assignee: Kuraray Company Limited
• Inventors: Yano, Makoto, Shibatani, Kyoichiro, Shimada, Kiyoo, Makimoto, Tsutomu
• Primary Examiner(s): Kaplan, G. L.
• Application Number:
  US05/907,729
• Time in Patent Office: 1,124 Days
• Field of Search: 357/25, 204/195 P, 204/195 M, 128/635, 324/29, 435/817
• US Class Current: 204/415
• CPC Class Codes: G01N 27/414 Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• CPC Class Codes: Y10S 435/817 Enzyme or microbe electrode

Abstract

A chemical sensitive field effect transistor transducer is provided having a semipermeable membrane on the surface of a chemical selective system overlying an insulated gate field effect transistor. Such a field effect transistor transducer is effective for the measurement of chemical constituents of factory waste water containing micro-particles, saliva or blood containing proteins, etc., where conventional devices give unreliable results.

Claims

1. A selective chemically sensitive FET transducer which selectively detects specific chemical substances to which the transducer is exposed, which comprises:

an FET transducer whose gate region is overlayed with a chemically selective sensitive membrane, which reacts or interacts with a specific chemical substance(s) and which is provided with a semipermeable membrane having a water content greater than 10% overlying said chemically selective sensitive membrane, said semipermeable membrane consisting of a hydrophillic membrane material(s) or a hydrophobic membrane material(s), each of said maerial(s) containing a light darkening dye or pigment.

2. The transducer of claim 1, wherein said semipermeable membrane is prepared by dissolving or dispersing a light darkening dye or pigment in the polymer or monomer soluion from which said membrane is cast.

3. The transducer of claim 2, wherein said pigment is carbon black.

4. The transducer of claim 1, wherein said semipermeable membrane is dyed after it has been cast on said surface of the gate region.

6. The transducer of claim 1 or 5, wherein the thickness of said semipermeable membrane is between 0.1μ

and 5 mm.

7. The transducer of claim 1 or 5, wherein the average optical density of said semipermeable membrane using light of 350 nm to 700 nm wavelength is more than 0.7 when measured perpendicular to the surface.

8. The transducer of claim 1 or 5, wherein said semipermeable membrane is heparinized.

9. The transducer of claim 1, wherein said semipermeable membrane is formed of a hydrophilic material selected from the group consisting of a polymethacrylate, a polyacrylate, a polyacrylamide, a polyvinylpyrrolidone, a polyvinylalcohol and copolymers thereof.

5. A selective chemically sensitive FET transductor which selectively detects specific chemical substances to which the transducor is exposed, which comprises:

an FET transducer whose gate region is overlayed with a chemically selective sensitive membrane, which reacts or interacts with a specific chemical substance(s) and which is provided with a semipermeable membrane having a water content greater than 10%, overlying said chemically selective sensitive membrane, said semipermeable membrane being formed of a hydrophilic material selected from the group consisting of a polymethacrylate, a polyacrylate, a polyacrylamide, a polyvinylpyrrolidone, a polyvinyl alcohol and copolymers thereof.

10. The transducer of claim 5 or 9, wherein said membrane is a hydrogel containing 20-90% water.

11. The transducer of claim 5 or 9, wherein said semipermably membrane material is poly-β

-hydroxyethyl methacrylate.

12. The transducer of claim 5 or 9, wherein the said semipermeable membrane material is a copolymer formed from β

-hydroxyethylmethacrylate and comonomers selected from the group consisting of hydroxypropyl acrylate, acrylate or methacrylate esters having the formuls CH₂ ═

C(R)COO-(CH₂ CH₂ O)_n R'"'"', wherein R is H or CH₃ and R'"'"' is aryl, alkyl, --CH₂ CH₂ OH, --NH₂, --NHCH₃ m -N(CH₃)₂, --N(CH₃)₃ +, and n is an integer, styrene, methyl methacrylate ethylene glycol dimethacrylate, glycidyl methacrylate, and graft copolymers of poly-styrene or poly-methyl methacrylate on poly-β

-hydroxyethyl methacrylate.