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Ultrasonic image enhancement

  • US 4,276,885 A
  • Filed: 05/04/1979
  • Issued: 07/07/1981
  • Est. Priority Date: 05/04/1979
  • Status: Expired due to Term
First Claim
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1. A method of enhancing ultrasonic echographic imaging in a liquid enclosed in a vessel by increasing image contrast, comprising:

  • providing a plurality of microbubbles in said liquid, each of said microbubbles having a coalescence resistant surface membrane encapsulating a gas of a selected composition, said membrane including a multiplicity of non-toxic and non-antigenic organic molecules, said microbubbles having a diameter of no more than about 300 microns and no less than about 0.5 micron; and

    obtaining an enhanced ultrasonic echographic image of said liquid opposite a position therein containing said microbubbles by increasing the relative contrast between said liquid and said vessel.

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