Method and apparatus for metered infusion of fluids

• US 4,278,085 A
• Filed: 12/13/1979
• Issued: 07/14/1981
• Est. Priority Date: 12/13/1979
• Status: Expired due to Term

• Current Assignee: Baxter Travenol Laboratories Incorporated
• Original Assignee: Baxter Travenol Laboratories Incorporated
• Inventors: Shim, Norm
• Primary Examiner(s): Pellegrino, Stephen C.
• Application Number:
  US06/103,041
• Time in Patent Office: 579 Days
• Field of Search: 128/214 R, 128/214 B, 128/214 E, 128/214 F, 128/214.2, 128/330, 128/273, 128/DIG. 12, 128/DIG. 13, 417/474-477, 417/441, 251/7, 251/8, 222/14-22
• US Class Current: 604/500
• CPC Class Codes: A61M 5/14232 Roller pumps
• CPC Class Codes: A61M 5/16804 Flow controllers
• CPC Class Codes: A61M 5/16854 by monitoring line pressure
• CPC Class Codes: Y10S 128/12 Pressure infusion

Abstract

Metering apparatus for metering the flow of fluid through an administration set includes a peristaltic-type metering pump which repeatedly and progressively compresses a section of vinyl tubing of the administration set to provide a desired flow rate. For improved metering accuracy the fluid is maintained under pressure upline and downline of the metering pump to assist the tubing in becoming fully restored following each compression by the pump. In the illustrated embodiment, upline pressure is provided by a peristaltic-type pressure pump which is operated at a controlled rate to maintain a predetermined upline pressure, and downline pressure is provided by a spring-biased plunger which bears against the tubing downline of the metering pump to partially occlude the tubing.

Claims

1. In a flow system for infusing a fluid from a supply reservoir into the human body, having, in combination:

a length of flexible-walled tubing extending from the supply reservoir to the body, said tubing exhibiting incomplete restoration upon repeated compressive cycling thereof;

metering means continuously including at least one pressure means compressively engaged to the sidewall of said tubing for completely occluding the lumen thereof;

drive means for advancing the point of engagement of said pressure means along a segment of said tubing, the lumen of said tubing being repetitively and progressively compressed and restored along said segment to urge fluid through said tubing;

downline pressurization means for continuously at least partially restricting the lumen of said tubing downline of said tubing segment to increase the pressure of the fluid within said segment downline of said point of engagement;

the improvement comprising;

upline pressurization means operatively engaging said tubing for increasing the pressure of said fluid in said segment upline of said point of engagement, the increase in pressure of said fluid at said point of engagement assisting in post-compressive reformation of said tubing for improved metering accuracy.

2. A flow system as defined in claim 1 including pressure control means responsive to the pressure in said tubing upline of said point of engagement for varying the operation of said upline pressurization means to maintain said upline pressures at a predetermined level.

3. A flow system as defined in claim 2 wherein said pressure control means are also responsive to the rate of advance of said pressure means along said tubing segment.

4. A flow system as defined in claim 3 wherein said drive means advance said pressure means to maintain a predetermined fluid flow rate through said tubing, and wherein said predetermined upline pressure maintained by said upline pressurization means varies as a function of said predetermined rate.

5. A flow system as defined in claim 1 wherein said upline pressurization means comprise additional pressure means compressively engaged to the sidewall of said tubing for at least partially occluding the lumen thereof, and additional drive means for advancing the point of engagement of said additional pressure means along an additional segment of said tubing.

6. A flow system as defined in claim 5 including pressure control means responsive to the pressure of said fluid in said tubing between said pressure means and said additional pressure means to maintain a predetermined pressure in said tubing.

7. A flow system as defined in claim 6 wherein said pressure control means vary the rate of advance of said additional pressure means along said additional segment.

8. A flow system as defined in claim 6 including pressure sensing means disposed along said tubing between said segment and said additional segment for providing a control signal indicative of the fluid pressure level in said tubing between said pressure means and said additional pressure means, said additional drive means being responsive to said control signal to vary the drive of said additional pressure means to maintain a predetermined pressure level at said sensing means.

9. A flow system as defined in claim 8 wherein said control signal is applied to said additional drive means to vary the rate of advance of said additional pressure means along said additional segment.

10. A flow system as defined in claim 1 wherein said tubing is formed of vinyl.

11. A flow system as defined in claim 1 wherein said downline pressurization means comprise a slidably-mounted plunger spring-biased against the sidewall of said tubing.

12. In a flow system for infusing a fluid from a supply reservoir into the human body, having, in combination:

a length of flexible-walled tubing extending from the supply reservoir to the body, said tubing exhibiting incomplete restoration upon repeated compressive cycling thereof;

metering means including a rotor having along its circumference a plurality of pressure members, at all times at least one of said pressure members being in compressive engagement with the sidewall of said tubing and completely occluding the lumen thereof;

means including a pressure plate for bringing said tubing into compressive engagement with said one of said pressure members;

drive means for rotatably driving said rotor whereby the lumen of said tubing is repetitively and progressively compressed and restored along said segment to urge fluid through said tubing;

downline pressurization means for continuously at least partially restricting the lumen of said tubing downline of said tubing segment to increase the pressure of the fluid within said segment downline of said point of engagement of said pressure member;

the improvement comprising;

upline pressurization means operatively engaging said tubing for increasing the pressure of said fluid in said segment upline of said point of engagement, said increase in pressure of said fluid at said point of engagement assisting in post-compressive reformation of said tubing for improved metering accuracy.

13. A flow system as defined in claim 12 including pressure control means responsive to the pressure in said tubing upline of said point of engagement for varying the operation of said upline pressurization means to maintain said upline pressures at a predetermined level.

14. A flow system as defined in claim 13 wherein said pressure control means are also responsive to the rate of advance of said pressure means along said tubing segment.

15. A flow system as defined in claim 14 wherein said drive means rotate said rotor to maintain a predetermined fluid flow rate through said tubing, and wherein said predetermined upline pressure maintained by said upline pressurization means varies as a function of the speed of rotation of said rotor.

16. A flow system as defined in claim 12 wherein said upline pressurization means comprise additional pressure means compressively engaged to the sidewall of said tubing for at least partially occluding the lument thereof, and additional drive means for advancing the point of engagement of said additional pressure means along an additional segment of said tubing.

17. A flow system as defined in claim 16 including pressure control means responsive to the pressure of said fluid in said tubing between said pressure means and said additional pressure means for varying the operation of said additional pressure means to maintain a predetermined pressure in said tubing.

18. A flow system as defined in claim 12 wherein said pressure members are disposed in equispaced relationship on the circumference of said rotor, and said pressure plate brings said tubing into engagement with said pressure member only over a segment of said tubing substantially corresponding to the spacing of said pressure members on the circumference of said rotor.

19. A flow system as defined in claim 12 wherein said downline pressurization means comprise a slidably mounted plunger spring-biased against the wall of said tubing.

20. A flow system as defined in claim 12 wherein said upline pressurization means comprise:

an additional plurality of pressure members, at all times at least one of said pressure members being in compressive engagement with the sidewall of said tubing so as to at least partially occlude the lumen thereof;

means including an additional pressure plate for bringing said tubing into compressive engagement with said one of said pressure members; and

additional drive means for rotatably driving said rotor whereby the lumen of said tubing is repetitively and progressively restored along an additional segment of said tubing to increase the pressure of said fluid upline of said point of engagement.

21. A flow system as defined in claim 20 wherein said pressure plates are formed as a single unit and mounted for reciprocative movement into and out of engagement with said pressure members.

22. A flow system as defined in claim 20 wherein said additional drive means comprise a rotational coupling between said rotors.

23. A flow system as defined in claims 20 including a stepper motor for driving said rotor of said upline pressurization means, and pressure control means responsive to the pressure in said tubing upline of the point of engagement of said pressure member of said metering means, and downline of the point of engagement of said pressure member of said upline pressurization means, for applying stepping pulses to said stepper motor at a rate which maintains a desired predetermined upline pressure level at said point of engagement.

24. A flow system as defined in claim 12 wherein said tubing is formed of vinyl.

25. In a metering apparatus for infusing a fluid from a supply reservoir to the human body through a length of flexible-walled tubing of the type exhibiting incomplete restoration upon repeated compressive cycling thereof, having, in combination:

metering means continuously including at least one pressure means compressively engaged to the sidewall of the tubing for completely occluding the lumen thereof;

drive means for advancing the point of engagement of said pressure means along a segment of the tubing, the lumen of the tubing being repetitively and progressively compressed and restored along said segment to urge fluid through the tubing;

downline pressurization means for continuously at least partially restricting the lumen of the tubing downline of said tubing segment to increase the pressure of the fluid within said segment downline of said point of engagement;

the improvement comprising;

upline pressurization means operatively engaging said tubing for increasing the pressure of said fluid in said segment upline of said point of engagement, the increase in pressure of said fluid at said point of engagement assisting in post-compressive reformation of said tubing for improved metering accuracy.

26. Metering apparatus as defined in claim 25 including pressure control means responsive to the pressure in said tubing upline of said point of engagement for varying the operation of said upline pressurization means to maintain said upline pressures at a predetermined level.

27. Metering apparatus as defined in claim 26 wherein said pressure control means are also responsive to the rate of advance of said pressure means along said tubing segment.

28. Metering apparatus as defined in claim 27 wherein said drive means advance said pressure means to maintain a predetermined fluid flow rate through said tubing, and wherein said predetermined upline pressure maintained by said upline pressurization means varies as a function of said predetermined rate.

29. Metering apparatus as defined in claim 25 wherein said upline pressurization means comprise additional pressure means compressively engaged to the sidewall of said tubing for at least partially occluding the lumen thereof, and additional drive means for advancing the point of engagement of said additional pressure means along an additional segment of said tubing.

30. Metering apparatus as defined in claim 29 including pressure control means responsive to the pressure of said fluid in said tubing between said pressure means and said additional pressure means for varying the operation of said additional pressure means to maintain a predetermined pressure in said tubing.

31. Metering apparatus as defined in claim 30 wherein said pressure control means vary the rate of advance of said additional pressure means along said additional segment.

34. Metering apparatus as defined in claim 25 wherein said tubing is formed of vinyl.

35. Metering apparatus as defined in claim 25 wherein said downline pressurization means comprise a slidably-mounted plunger spring-biased against the sidewall of said tubing.

36. In a metering apparatus for infusing a fluid from a supply reservoir to the human body through a length of flexible-walled tubing of the type exhibiting incomplete restoration upon repeated compressive cycling thereof;

having;

metering means including a rotor having along its circumference a plurality of pressure members, at all times at least one of said pressure members being in compressive engagement with the sidewall of the tubing and completely occluding the lumen thereof;

means including a pressure plate for bringing the tubing into compressive engagement with said one of said pressure members along a segment of said tubing;

drive means for rotatably driving said rotor whereby the lumen of the tubing is repetitively and progressively compressed and restored along said segment to urge fluid through the tubing;

downline pressurization means for continuously at least partially restricting the lumen of the tubing downline of said tubing segment to increase the pressure of the fluid within said segment to increase the pressure of the fluid within said segment downline of point of engagement of said pressure member;

the improvement comprising;

upline pressurization means operatively engaging said tubing for increasing the pressure of said fluid in said segment upline of said point of engagement, the increase in pressure of said fluid at said point of engagement assisting in post-compressive reformation of said tubing for improved metering accuracy.

32. Metering apparatus as defined in claim 39 including pressure sensing means disposed along said tubing between said segment and said additional segment for providing a control signal indicative of the fluid pressure level in said tubing between said pressure means and said additional pressure means, said additional drive means being responsive to said control signal to vary the drive of said additional pressure means to maintain a predetermined pressure level at said sensing means.

33. Metering apparatus as defined in claim 32 wherein said control signal is applied to said additional drive means to vary the rate of advance of said additional pressure means along said additional segment.

37. Metering apparatus as defined in claim 36 including pressure control means responsive to the pressure in said tubing upline of said point of engagement for varying the operation of said upline pressurization means to maintain said upline pressures at a predetermined level.

38. Metering apparatus as defined in claim 37 wherein said pressure control means are also responsive to the rate of advance of said pressure means along said tubing segment.

39. Metering apparatus as defined in claim 38 wherein said drive means rotate said rotor to maintain a predetermined fluid flow rate through said tubing, and wherein said predetermined upline pressure maintained by said upline pressurization means varies as a function of the speed of rotation of said rotor.

40. Metering apparatus as defined in claim 36 wherein said upline pressurization means comprise additional pressure means compressively engaged to the sidewall of said tubing for at least partially occluding the lumen thereof, and additional drive means for advancing the point of engagement of said additional pressure means along an additional segment of said tubing.

41. Metering apparatus as defined in claim 40 including pressure control means responsive to the pressure of said fluid in said tubing between said pressure means and said additional pressure means for varying the operation of said additional pressure means to maintain a predetermined pressure in said tubing.

42. Metering apparatus as defined in claim 36 wherein said pressure members are disposed in equispaced relationship on the circumference of said rotor, and said pressure plate brings said tubing into engagement with said pressure member only over a segment of said tubing substantially corresponding to the spacing of said pressure members on the circumference of said rotor.

43. Metering apparatus as defined in claim 36 wherein said downline pressurization means comprise a slidably-mounted plunger spring-biased against the wall of said tubing.

44. Metering apparatus as defined in claim 36 wherein said upline pressurization means comprise:

an additional plurality of pressure members, at all times at least one of said pressure members being in compressive engagement with the sidewall of said tubing so as to at least partially occlude the lumen thereof;

means including an additional pressure plate for bringing said tubing into compressive engagement with said one of said pressure members; and

additional drive means for rotatably driving said rotor whereby the lumen of said tubing is repetitively and progressively restored along an additional segment of said tubing to increase the pressure of said fluid upline of said point of engagement.

45. Metering apparatus as defined in claim 44 wherein said pressure plates are formed as a single unit and mounted for reciprocative movement into and out of engagement with said pressure members.

46. Metering apparatus as defined in claim 44 wherein said additional drive means comprise a rotational coupling between said rotors.

47. Metering apparatus as defined in claim 44 including a stepper motor for driving said rotor of said upline pressurization means, and pressure control means responsive to the pressure in said tubing upline of the point of engagement of said pressure member of said metering means, and downline of the point of engagement of said pressure member of said upline pressurization means, for applying stepping pulses to said stepper motor at a rate which maintains a desired predetermined upline pressure level at said point of engagement.

48. Metering apparatus as defined in claim 36 wherein said tubing is formed of vinyl.

49. In a metering apparatus for infusing a fluid from a supply reservoir to the human body through a length of flexible-walled tubing of the type exhibiting incomplete restoration upon repeated compressive cycling thereof, having, in combination:

metering means including a rotor having in equispaced relationship along its circumference a plurality of pressure members, at all times at least one of said pressure members being in compressive engagement with the sidewall of said tubing and completely occluding the lumen thereof;

means including a pressure plate for bringing said tubing into compressive engagement with said one of said pressure members only over a segment of said tubing substantially corresponding to the spacing of said pressure members on the circumference of said rotor;

drive means for rotatably driving said rotor whereby the lumen of said tubing is repetitively and progressively compressed and restored along said segment to urge fluid through said tubing;

downline pressurization means comprising a movable plunger spring-biased against the wall of said tubing, for continuously at least partially restricting the lumen of said tubing downline of said tubing segment to increase the pressure of the fluid within said segment downline of said point of engagement of said pressure member;

the improvement comprising;

upline pressurization means comprising a rotor having along its circumference a plurality of pressure members, at all times at least one of said pressure members being in compressive engagement with the sidewall of said tubing and at least partially occluding the lumen thereof;

means including an additional pressure plate for bringing said tubing into compressive engagement with said one of said pressure members of said upline pressurization means;

additional drive means for rotatably driving said rotor whereby the lumen of said tubing is repetitively and progressively compressed and restored to urge fluid through said tubing; and

pressure control means responsive to the pressure of said fluid upline of said point of engagement of said pressure members of said metering means for varying the speed of rotation of said additional rotor to maintain said upline pressure at a predetermined level for improved metering accuracy.

50. The method of infusing a fluid from a supply reservoir into the human body, comprising the steps of:

establishing a flow path between the supply reservoir and the human body through a length of flexible-walled tubing of the type exhibiting incomplete restoration upon repeated compressive cycling thereof;

continuously compressing the sidewall of said tubing so as to completely occlude said tubing;

repetitively advancing the point of compression of said tubing along a segment thereof whereby the lumen of said tubing is repetitively and progressively compressed and restored along said segment to urge fluid through said tubing; and

increasing the pressure of the fluid within said segment upline of said point of compression to assist in reformation of said tubing segment for improved metering accuracy.

51. The method of infusing a fluid defined in claim 50 comprising the additional step of at least partially restricting the lumen of said tubing downline of said tubing segment to increase the pressure of the fluid within said segment both upline and downline of said point of compression.

52. The method of infusing fluid as defined in claim 50 wherein the flow path is established through flexible-walled vinyl tubing.