Preventative treatment for Otitis externae

• US 4,278,664 A
• Filed: 02/06/1978
• Issued: 07/14/1981
• Est. Priority Date: 08/12/1976
• Status: Expired due to Term

• Current Assignee: Ruth M. Van Cleave
• Original Assignee: Zarley McKee Thompte Voorhees & Sease
• Inventors: Van Cleave, Jon S.
• Primary Examiner(s): Waddell, Frederick E.
• Application Number:
  US05/875,320
• Time in Patent Office: 1,254 Days
• Field of Search: 424/148, 424/307, 424/308
• US Class Current: 424/659
• CPC Class Codes: A61F 11/00 Methods or devices for treatment of the ears or hearing sense implantable prostheses that substitute or replace internal ear parts, e.g. ear-drums, A61F2/18; methods or devices to cause a change in the state of auditory consciousness A61M21/00; electrotherapy applying electrical stimulation of the auditory system, or circuits therefor A61N1/36; radiotherapy using optical stimulation of the auditory system A61N5/06; electro-acoustic hearing aids H04R25/00; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand headwear, e.g. caps or helmets, with means for protecting the ears A42B1/0188, A42B3/16
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 9/0046 Ear

Abstract

A preventative composition for Otitis externae, commonly referred to as "Swimmer'"'"'s Ear," and for eliminating the discomfort of water remaining in the external canal, which comprises applying to the skin surface of the external auditory canal of a patient'"'"'s ear, a pharmaceutically safe, liquid, nonionic, substantially water insoluble, aqueous surface tension reducing agent.

Claims

1. A composition for preventive treatment for swimmer'"'"'s ear said composition comprising,

a pharmaceutically safe, liquid, non-ionic, substantially water insoluble aqueous surface tension reducing agent, in combination with an effective buffering amount of, a pharmaceutically safe non-skin irritating acidifying agent, and

a pharmaceutically acceptable medicinal agent which is non-irritating, in an amount which is effective to prevent said surfactant from providing a medium for bacterial growth.

2. The composition of claim 1 wherein said surface active agent is polyoxyethylene sorbitol oleate.

3. The composition of claim 2 wherein said boric acid is added within the range of from 0.1% to about 1.5% by weight of said surface active agent, to provide a pH within the range of from about 5 to about 6 to said composition.

4. The composition of claim 3 wherein said boric acid is added at a level of from 0.1% by weight to 1.0% by weight of said surfactant.

5. The composition of claim 1 wherein said medicinal agent is selected from the group consisting of methyl and propyl esters of para-hydroxybenzoic acid.

6. The composition of claim 5 wherein said esters are present at a percentage with level by weight of the surfactant within the range of from 0.1% up to about 2.0% by weight.

7. The composition of claim 6 wherein both methyl and propyl esters of para-hydroxybenzoic acid are present with the ratio of methyl to propyl being about 2 to 1.

8. The composition of claim 1 wherein said pharmaceutically safe, non-skin irritating acid is boric acid.

9. The composition of claim 1 wherein said pharmaceutically safe liquid non-ionic substantially water insoluble surface tension reducing agent is selected from the group consisting of those having an ether linkage, an ester linkage, an ester-ether linkage and an amide linkage.

10. A composition for preventive treatment for swimmer'"'"'s ear, said composition comprising,

a pharmaceutically safe, liquid, non-ionic substantially water insoluble aqueous surface tension reducing agent selected from the group consisting of those having an ether linkage, an ester linkage, an ester-ether linkage and an amide linkage, in combination with from about 1% to about 1.5% by weight of said surface active agent of a pharmaceutically safe, non-skin irritating acid, and from about 0.1% to about 2.0% by weight of said surface active agent of a medicinal agent selected from the group consisting of methyl and propyl esters of parahydroxybenzoic acid.

11. The composition of claim 10 wherein both methyl and propyl esters of parahydroxybenzoic acid are present with the ratio of methyl to propyl being about 2 to 1.