Analgesic mixture of nalbuphine and acetylsalicylic acid, derivative or salt thereof

• US 4,282,215 A
• Filed: 07/28/1980
• Issued: 08/04/1981
• Est. Priority Date: 06/17/1980
• Status: Expired due to Term

• Current Assignee: DuPont Pharmaceuticals Co (Bristol-Myers Squibb Company)
• Original Assignee: E. I. du Pont de Nemours and Company (Corteva, Inc.)
• Inventors: Schmidt, William K., Dudzinski, John R.
• Primary Examiner(s): Friedman, Stanley J.
• Application Number:
  US06/170,931
• Time in Patent Office: 372 Days
• Field of Search: 424/232
• US Class Current: 514/161
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof

Abstract

A composition consisting essentially of nalbuphine and acetylsalicylic acid, derivative or salt thereof, gives unexpectedly enhanced analgetic activity.

Claims

1. A pharmaceutical composition consisting essentially of (a) nalbuphine or a pharmaceutically suitable acid addition salt thereof and (b) acetylsalicylic acid, sodium acetylsalicylate, calcium acetylsalicylate, salicylic acid, or sodium salicylate or any combination thereof in a weight ratio of (a) to (b) of from about 1:

1.76 to about 1;

61.7.

2. A composition of claim 1 wherein component (b) is acetylsalicylic acid, sodium acetylsalicylate or calcium acetylsalicylate.

3. A composition of claim 2 wherein component (b) is acetylsalicylic acid.

4. A composition of claim 2 wherein component (b) is sodium acetylsalicylate.

5. A composition of claim 2 wherein component (b) is calcium acetylsalicylate.

6. A composition of claim 2 wherein the weight ratio is from about 1:

3 to about 1;

50.

7. A composition of claim 2 wherein the weight ratio is from about 1:

12 to about 1;

45.

8. A composition of claim 2 wherein the nalbuphine is present as the hydrochloride salt.

9. A composition of claim 1 which contains in addition a suitable pharmaceutical carrier.

10. A composition of claim 2 which contains in addition a suitable pharmaceutical carrier.

11. A composition of claim 3 which contains in addition a suitable pharmaceutical carrier.

12. A composition of claim 4 which contains in addition a suitable pharmaceutical carrier.

13. A composition of claim 5 which contains in addition a suitable pharmaceutical carrier.

14. A composition of claim 6 which contains in addition a suitable pharmaceutical carrier.

15. A composition of claim 7 which contains in addition a suitable pharmaceutical carrier.

16. A composition of claim 8 which contains in addition a suitable pharmaceutical carrier.

17. A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 1.

18. A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 2.

19. A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 3.

20. A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 4.

21. A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 5.

22. A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 6.

23. A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 7.

24. A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 8.