Method and apparatus for pumping blood within a vessel

• US 4,284,073 A
• Filed: 05/10/1979
• Issued: 08/18/1981
• Est. Priority Date: 10/11/1977
• Status: Expired due to Term

• Current Assignee: Edwin L. Stanley, Horst E. Krause
• Original Assignee: Edwin L. Stanley, Horst E. Krause
• Inventors: Stanley, Edwin L., Krause, Horst E.
• Primary Examiner(s): Truluck, Dalton L.
• Application Number:
  US06/037,766
• Time in Patent Office: 831 Days
• Field of Search: 128/1 D, 128/218 A, 128/348, 128/214 F, 128/227, 128/66
• US Class Current: 600/18
• CPC Class Codes: A61B 5/201 Assessing renal or kidney functions
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61M 2205/33 Controlling, regulating or measuring
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 60/13 by means of a catheter allowing explantation, e.g. catheter pumps temporarily introduced via the vascular system
• CPC Class Codes: A61M 60/139 inside the aorta, e.g. intra-aortic balloon pumps
• CPC Class Codes: A61M 60/274 the inlet and outlet being the same, e.g. para-aortic counter-pulsation blood pumps
• CPC Class Codes: A61M 60/295 Balloon pumps for circulatory assistance
• CPC Class Codes: A61M 60/33 of kidneys
• CPC Class Codes: A61M 60/497 for balloon pumps for circulatory assistance
• CPC Class Codes: A61M 60/515 Regulation using real-time patient data
• CPC Class Codes: A61M 60/89 Valves

Abstract

A dynamically augmenting pump system incorporates a sealed liquid-filled catheter which is inserted into a vessel such as an artery, and the pump system is operated in timed relation with the heart to aid the heart during episodes of impairment or failure of cardiac function by producing higher frequency pulsation or pressure waves within the blood during diastole and during the isometric contraction period of the heart. This frequency of pulsation is adjusted to the dynamic transmission characteristics of a selected circulatory subsystem, such as the coronary vascular system, to assure the transmission of a maximum of pulsatile energy into the subsystem. The catheter provides energy to maintain adequate blood flow through the healthy part of the myocardium and has a passage for injecting successive quantities of medication into the coronary arteries. The pump system also functions to penetrate the ischemic myocardial tissue with arterial blood and medication. The pump system may also be used to provide enhanced perfusion for other parts of the systemic circulatory system, for example, to prevent such detrimental effects as renal failure. Any one or combination of the functions may be used depending on the special medical conditions of the patient.

Claims

1. A method for perfusing a body organ or tissue containing a body fluid, comprising the steps of forming a catheter having an inflatable portion and enclosing a fluid adapted to be pulsated, inserting the inflatable portion of the fluid-filled catheter into a vessel within the organ or tissue, and pulsating the fluid enclosed within the catheter at a frequency substantially greater than the normal pulsation frequency of the heart for transmitting pulsatile energy and for producing an amplified dynamic pressure wave form in the body fluid in response to inflation and deflation of the inflatable catheter portion to increase the penetration of the body fluid into the microcirculatory resistance vessels within the body tissue or organ.

2. A method as defined in claim 1 and including the steps of monitoring the pulsation of the heart, and producing repetitive trains of pulses in timed relation with the pulsation of the heart.

3. A method as defined in claim 2 wherein the repetitive trains of pulses are produced during the diastolic period and/or isometric contraction period of the heart.

4. A method as defined in claim 1 and including the step of selecting the amplitude and frequency of pulsation in accordance with a specific physiological requirement.

5. A method as defined in claim 1 and including the step of repetitively inflating and deflating the inflatable catheter portion in timed relation with heart pulses for generating and transmitting amplified pressure waves into tissue areas or organs during selected portions of the cardiac cycle.

6. A method as defined in claim 1 and including the step of producing pressure waves with sufficient amplitude to open previously collapsed small vessels within the tissue or organ.

7. A method as defined in claim 1 including the steps of monitoring the aortic blood pressure and the heart pulse of a patient, producing a visual display of the blood pressure and heart pulse, and pulsating the blood at the substantially greater frequency and in timed relation with the pulsation of the heart.

8. A method as defined in claim 1 and including the step of injecting a predetermined volume of medication in timed relation with the pulsating of the liquid.

9. Apparatus for perfusing a body organ or tissue containing a body fluid, comprising a catheter having an inflatable portion and enclosing a fluid adapted to be pulsated, the inflatable portion of the fluid-filled catheter adapted to be inserted into a vessel within the organ or tissue, and means for pulsating the fluid within the catheter at a frequency substantially greater than the normal pulsation frequency of the heart for transmitting pulsatile energy and for producing an amplified dynamic pressure wave form in the body fluid in response to inflation and deflation of the inflatable catheter portion to increase the penetration of the body fluid into the microcirculatory resistance vessels within the body tissue or organ.

10. Apparatus as defined in claim 9 and including control means for operating said pulsating means in timed relation with the heart pulsation.

11. Apparatus as defined in claim 9 wherein said inflatable portion of the catheter defines an annular chamber surrounding a tubular catheter portion defining a passage.

12. Apparatus as defined in claim 9 including means for injecting a medication fluid through the catheter.

13. Apparatus as defined in claim 9 including means for sensing the pulsating of the heart, and time delay means for actuating said pulsating means in response to operation of said sensing means.