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Process for manufacturing device with dispersion zone

  • US 4,285,987 A
  • Filed: 11/01/1979
  • Issued: 08/25/1981
  • Est. Priority Date: 10/23/1978
  • Status: Expired due to Term
First Claim
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1. A process for manufacturing a drug delivery device, which process comprises the steps of:

  • (a) pressing a drug formulation into a shaped, solid mass;

    (b) coating the mass with a composition comprising a semipermeable polymer permeable to the passage of fluid and impermeable to the passage of drug to form a semipermeable wall surrounding a compartment housing the formulation;

    (c) drilling an outlet passageway in the semipermeable wall of a predetermined size for osmotically pumping the formulation through the passageway;

    (d) coating the semipermeable wall with a layer of a member soluble in fluid that enters the device and is selected from the group consisting of a salt, a carbohydrate, and mixtures thereof, which layer separates the semipermeable wall from a microporous wall, said microporous wall formed by;

    (e) coating the layer with a composition comprising a microporous polymer to form a microporous wall surrounding the layer, thereby forming the device.

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