Blood compatible polymers and medical devices made therefrom containing dioctyladipate plasticizer

• US 4,286,597 A
• Filed: 04/21/1980
• Issued: 09/01/1981
• Est. Priority Date: 10/26/1978
• Status: Expired due to Term

• Current Assignee: Baxter Travenol Laboratories Incorporated (Baxter International Inc.)
• Original Assignee: Baxter Travenol Laboratories Incorporated (Baxter International Inc.)
• Inventors: Grode, Gerald A., Miripol, Jeffrey E., Measells, Paul E., Gajewski, Henry M.
• Primary Examiner(s): Pellegrino, Stephen C.
• Assistant Examiner(s): Wallen, T. J.
• Application Number:
  US06/142,290
• Time in Patent Office: 498 Days
• Field of Search: 128/214 D, 128/214 R, 128/272, 128/DIG. 24, 260/31.8 XA, 260/31.8 P, 260/31.8R
• US Class Current: 604/408
• CPC Class Codes: A61J 1/10 Bag-type containers
• CPC Class Codes: A61L 33/0005 Use of materials characterised by their function or physical properties
• CPC Class Codes: A61L 33/0052 Plasticizers
• CPC Class Codes: A61M 1/3687 Chemical treatment A61M1/3675 takes precedence
• CPC Class Codes: C08K 5/12 of cyclic polycarboxylic acids
• CPC Class Codes: C08L 67/02 Polyesters derived from dicarboxylic acids and dihydroxy compounds C08L67/06 takes precedence
• CPC Class Codes: Y10S 128/24 Medical-surgical bags

Abstract

Blood-compatible, chlorine-free polymers such as a flexible, non-toxic, sterilizable polyester plastic formulation may contain from 5 to 70 percent by weight of a blood-extractable plasticizer such as di-2-ethylhexyladipate, to cause blood which is stored in contact with the polymer to exhibit a surprisingly low hemolysis rate when compared with corresponding polymers which are free of the plasticizer. Accordingly, blood bags, tubing and other medical blood-contacting devices may be advantageously made from these polymers.

Claims

1. The method of storing blood which comprises placing said blood for a period of days into a flexible, hemocompatible, sterilizable, chlorine-free plastic material which contains sufficient dioctyladipate to cause a reduced plasma hemoglobin content of blood stored in contact therewith for 21 days, when compared with blood stored in contact with the same blood compatible material free of dioctyladipate.

2. The method of claim 1 in which said dioctyladipate contains branched octyl groups.

3. The method of claim 2 in which said dioctyladipate is di-2-ethylhexyladipate.

4. The method of claim 1 in which said chlorine-free plastic material contains from 5 to 50 percent by weight of said dioctyladipate.

5. The method of claim 4 in which from 15 to 40 percent by weight of said dioctyladipate is present.

6. The method of claim 1 in which said chlorine-free plastic material is a polyester.