Neuromuscular block monitor

• US 4,291,705 A
• Filed: 09/10/1979
• Issued: 09/29/1981
• Est. Priority Date: 09/10/1979
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Severinghaus, John W., Severinghaus, Edwin M.
• Primary Examiner(s): Michell, Robert W.
• Assistant Examiner(s): Jaworski, Francis J.
• Application Number:
  US06/073,889
• Time in Patent Office: 750 Days
• Field of Search: 128/630, 128/731-733, 128/774, 128/213, 128/741
• US Class Current: 600/546
• CPC Class Codes: A61B 2505/05 Surgical care
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/1106 to assess neuromuscular blockade, e.g. to estimate depth of anaesthesia
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/395 Details of stimulation, e.g. nerve stimulation to elicit EMG response

Abstract

To determine the degree of neuromuscular blockage, the apparatus of the invention electrically, supramaximally stimulates the motor nerve of a patient by stimulus means, applies the resulting electromyogram (EMG) produced by the muscle associated with that motor nerve and integrates the amplified EMG with respect to time. The integrated, amplified EMG is then displayed. In a preferred embodiment of the invention means are also provided for displaying the integrated, amplified EMG, taken after a muscle relaxant has been administered to the patient, as a ratio of a control EMG taken with the apparatus before the administration of the drug.

Claims

1. Apparatus for monitoring the neuromuscular transmission of a motor nerve and the muscle associated with the nerve in a patient, the apparatus comprising

stimulator means for generating a plurality of electrical stimulus signals which are spaced apart by predetermined periods of time and for applying such stimulus signals to the motor nerve to supramaximally stimulate it,

amplifier and detector means connected to the stimulator means, and including a pair of sensing electrodes adapted to be attached to the patient, for sensing the electromyogram (EMG) produced by the associated muscle as a result of the stimulating electrical signals and for amplifying the EMG,

electronic integrator means connected to the amplifier and detector means for receiving each amplified EMG in response to each stimulus signal and for integrating it with respect to time over periods which fall between stimulus signals,

control standard means connected to the integrator means for storing a representation of a first integrated EMG,

comparator means connected to the integrator means for generating an output signal which is representative of the ratio of a select, integrated EMG and the first, integrated EMG, and

means for displaying the output signal of the comparator means.

2. Apparatus as recited in claim 1 wherein the control standard means produce a reference signal representative of the integrated and stored first EMG, and wherein the comparator means include means for resetting the integrator means to a predetermined initial value whenever the integrated EMG output of the integrator means exceeds the reference signal.

3. Apparatus as recited in claims 1 or 2 wherein the comparator means generate an output signal which is representative of the ratio of the integrated, amplified EMG'"'"'s obtained from a patient after the administration of a muscle relaxant drug to the first integrated EMG when taken with the monitoring apparatus before the administration of a muscle relaxant drug.

4. Apparatus as recited in claim 1 wherein the stimulator means comprise a mode control circuit for selectively producing either a single pulse, a rapid series of pulses, or a predetermined number of pulses at regular intervals.

5. Apparatus as recited in claim 1 wherein the amplifier and detector means further comprise a rectifier for passing only negative polarity EMG'"'"'s.

6. Apparatus as recited in claim 1 wherein the integrating means integrates over a period of up to 8 milliseconds.

7. A method of monitoring meuromuscular blockage in a patient comprising the steps of

electrically, supramaximally stimulating a motor nerve of a patient before the administration of a muscle relaxant drug,

detecting amplifying the resulting electromyogram (EMG) produced by the muscle associated with the stimulated motor nerve,

integrating and holding the amplified EMG with respect to time to obtain an integrated control EMG,

repeating the stimulating, amplifying, integrating and holding steps after the administration of a muscle relaxant drug to the patient to obtain a second integrated EMG, and

displaying the ratio of the second integrated EMG to the integrated control EMG.

8. The method as recited in claim 7 comprising the further steps of repeating the stimulating, amplifying, and integrating steps after the administration of an antagonist drug to obtain a third integrated EMG and displaying the ratio of the third integrated EMG to the integrated control EMG.

9. The method as recited in claims 7 or 8 wherein in performing the repeated integrating steps the rate of integration is adjusted to be reference to a function of the integrated control EMG.