Apparatus and method for detection of tumors in tissue

• US 4,291,708 A
• Filed: 11/02/1978
• Issued: 09/29/1981
• Est. Priority Date: 11/02/1977
• Status: Expired due to Term

• Current Assignee: Transscan Medical Ltd.
• Original Assignee: Yeda Research and Development Co. Ltd. (Weizmann Institute of Science)
• Inventors: Frei, Ephraim H., Sollish, Bruce D.
• Primary Examiner(s): Michell, Robert W.
• Assistant Examiner(s): Jaworski, Francis J.
• Application Number:
  US05/956,926
• Time in Patent Office: 1,062 Days
• Field of Search: 128/630, 128/653, 128/734, 324/57 R, 324/575 S, 324/60 R, 324/62 R, 324/65 R, 364/481-482
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0091 for mammography
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence

Abstract

An apparatus for detecting tumors in living human breast tissue includes instrumentalities for determining the dielectric constants of a plurality of localized regions of living human breast tissue. These instrumentalities include a bridge which is provided with a circuit for automatically nulling the bridge while in operation. Instrumentalities are provided for measuring variations in the dielectric constants over a plurality of the regions and for indicating the possible presence of a tumor as result of the measurement. The apparatus may be utilized in carrying out a method of detecting tumors which includes the steps of applying a plurality of probe elements to human breast tissue for sensing characteristics of localized regions thereof, applying an electrical signal to the probe elements for determining dielectric constants of localized regions of the tissue, sensing variations in the dielectric constants and determining the rate-of-change of dielectric constant at each of the localized regions.

Claims

1. Apparatus for detecting tumors in living human breast tissue comprising:

means for determining the dielectric constants of a plurality of localized regions of living human breast tissue including a bridge means having means for automatically nulling said brigde means while in operation; and

means for measuring variations in said dielectric constants over a plurality of said regions and for indicating the possible presence of a tumor as a result of said measurement.

2. Apparatus for detecting tumors according to claim 1 and wherein said determining means comprises:

probe means;

means for applying a swept frequency signal to said probe means;

signal processing circuitry, coupled to said bridge for providing an output indication of dielectric constant of the localized region of breast tissue associated with said probe means.

3. Apparatus for detecting tumors according to claim 2 wherein said swept frequency signal varies in frequency between 0.1 and 10 KHz.

4. Apparatus according to claim 1 and also comprising means for recording a plurality of dielectric constant patterns for subsequent reference.

5. Apparatus according to claim 1 and wherein said determining means comprises:

probe means comprising a plurality of probe elements;

means for providing a swept frequency signal

switching means for selectably and sequentially connecting individual ones of said plurality of probe elements to said bridge and for connecting said probe elements not currently connected to said bridge to said means for providing a swept frequency signal; and

wherein

said indiciating means comprises a cathode ray tube display; and

wherein said apparatus also comprises

microcomputer controlled recording means for recording the dielectric constant information produced by said indicating means.

6. Apparatus for detecting tumors in living human breast tissue comprising:

means for determining the dielectric constants of a plurality of localized regions of living human breast tissue; and

means for indicating variations in said dielectric constants over a plurality of said regions, said variations indicating the possible presence of a tumor;

and wherein said determining means comprises;

probe means comprising a plurality of probe elements arranged for sensing different ones of said localized regions;

switching means for selectably applying an electrical signal to said probe elements;

a balancing bridge circuit coupled to said probe elements;

and

signal processing circuitry coupled to said balancing bridge for providing an output indication of dielectric constants of the localized regions of breast tissue associated with each of said probe elements.

7. Apparatus according to claim 6 and wherein said signal processing circuitry comprises an analog to digital converter.

8. Apparatus according to claim 6 and wherein said switching means comprises a multiplexer operated by a microcomputer.

9. Apparatus according to claim 6 and wherein said probe comprises an insulative housing and an 8×

8 array of probe elements and wherein said switching means is operative to couple only one of said probe elements at a time to said bridge.

10. Apparatus for detecting tumors in living human breast tissue comprising:

means for determining the variation of the dielectric constant of localized regions of living human breast tissue as a function of frequency of a signal applied thereto and including automatic balancing bridge means which do not require nulling for each measurement; and

means for indicating differences in said variation over a plurality of said localized regions, said differences indicating the possible presence of a tumor.

11. Apparatus according to claim 10 and wherein said determining means comprises:

probe means comprising a plurality of probe elements;

means for providing a swept frequency signal;

switching means for selectively and sequentially connecting individual ones of said plurality of probe elements to said balancing bridge and for connecting said probe elements not currently connected to said balancing bridge to said means for providing a swept frequency signal.

12. Apparatus according to claim 11 and wherein said indicating means comprises a cathode ray tube display and wherein said apparatus also comprises microcomputer controlled recording means for recording the dielectric constant variation information produced by said indicating means.

13. A method for detecting tumors in living human breast tissue comprising the steps of:

applying probe means comprising a plurality of probe elements to human breast tissue in vivo such that individual ones of said probe elements are arranged for sensing characteristics of individual localized regions of human breast tissue;

selectably applying an electrical signal to said probe elements for determining the dielectric constants of said localized regions of living human breast tissue; and

detecting a possible tumor by sensing variations in said dielectric constants over a plurality of said regions.

14. A method according to claim 13 and also comprising the step of:

determining the dielectric constants of said localized regions at a plurality of signal frequencies.

15. A method for detecting tumors in living human breast tissue comprising the steps of:

applying probe means comprising a plurality of probe elements to human breast tissue in vivo such that individual ones of said probe elements are arranged for sensing characteristics of individual localized regions of human breast tissue;

selectably applying an electric signal to said probe elements for determining the dielectric constants of said localized regions of living human breast tissue;

sensing variations in said dielectric constants over a plurality of said regions to indicate the possible presence of a tumor; and

determining the rate of change of dielectric constant with frequency at each of said localized regions.

16. A method for detecting tumors in living human breast tissue comprising the steps of:

applying probe means comprising a plurality of probe elements to human breast tissue in vivo such that individual ones of said probe elements are arranged for sensing characteristics of individual localized regions of human breast tissue;

selectably applying an electrical signal to said probe elements for determining the dielectric constants of said localized regions of living human breast tissue;

sensing variations in said dielectric constants over a plurality of said regions to indicate the possible presence of a tumor; and

determining the rate of change of dielectric constant with log of frequency at each of said localized regions.