Slow-releasing medical preparation to be administered by adhering to a wet mucous surface

• US 4,292,299 A
• Filed: 07/07/1980
• Issued: 09/29/1981
• Est. Priority Date: 11/06/1978
• Status: Expired due to Term

• Current Assignee: Teijin Limited
• Original Assignee: Teijin Limited
• Inventors: Suzuki, Yoshiki, Ikura, Hiroshi, Yamashita, Gentaro
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US06/202,384
• Time in Patent Office: 449 Days
• Field of Search: 128/156, 128/260, 128/268, 424/14, 424/16, 424/19-22, 424/28
• US Class Current: 424/435
• CPC Class Codes: A61K 9/006 Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
• CPC Class Codes: A61K 9/209 containing drug in at least two layers or in the core and in at least one outer layer
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092

Abstract

PCT No. PCT/JP79/00284 Sec. 371 Date Nov. 6, 1979 Sec. 102(e) Date July 7, 1980 PCT Filed July 7, 1980 PCT Pub. No. WO80/00916 PCT Pub. Date May 15, 1980

A medical preparation composed of an adhesive layer comprising polymers which have adhesiveness to a wet mucous surface and swellability upon moistening and a nonadhesive layer which has no adhesiveness to a wet mucous surface and is water soluble or water disintegrable, with at least one of the layers made to contain a medicament. The medical preparation is administered by adhering to a wet mucous surface of the mucous membrane and skin of men or animals, whereby exhibiting a property to release the medicament slowly extending over a long period of time to cure or prevent general or local diseases.

Claims

1. A slow-releasing medical preparation to be administered by adhering to a wet mucous surface comprising an adhesive layer composed of a polymer which has the adhesiveness to a wet mucous surface and a property to swell upon moistening and a nonadhesive, either water soluble or disintegrable, layer which has no adhesiveness to a wet mucous surface and at least either one of said adhesive layer and nonadhesive layer is made to contain a medicament.

2. A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein a medicament is contained in the adhesive layer as an intimate mixture.

3. A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the thickness of the adhesive layer is about 0.1 to 2.5 mm.

4. A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the adhesive layer has the adhesiveness of about 40 g/cm² (adhesion area) or more.

5. A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the preparation assumes the form of a tablet consisting of two layers.

6. A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the polymer of the adhesive layer is at least one polymer selected from a group comprising acrylic acids or their pharmaceutically acceptable nontoxic salts, copolymers of acrylic acid or their pharmaceutically acceptable nontoxic salts, hydrophilic vinyl copolymers not copolymerized with acrylic acid as a main component, hydrophilic cellulose derivatives, polysaccharides or their derivatives and gelatine or collagen or their derivatives with improved swellability.

7. A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the polymer of the adhesive layer is a mixture of cellulose ether and polyacrylic acid (or its salt) or copolymer of acrylic acid (or its salt).

8. A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the nonadhesive layer comprises lactose or glucose or their mixture.

9. A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 7, wherein the cellulose ether is methyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose or their mixture.