Therapeutic dimethyl sulfoxide composition and methods of use

• US 4,296,104 A
• Filed: 08/30/1979
• Issued: 10/20/1981
• Est. Priority Date: 08/30/1979
• Status: Expired due to Term

• Current Assignee: Robert J. Herschler
• Original Assignee: Robert J. Herschler
• Inventors: Herschler, Robert J.
• Primary Examiner(s): Friedman, Stanley J.
• Application Number:
  US06/071,072
• Time in Patent Office: 782 Days
• Field of Search: 424/322, 424/153, 424/337
• US Class Current: 424/679
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/10 Sulfides; Sulfoxides; Sulfones
• CPC Class Codes: A61K 31/16 Amides, e.g. hydroxamic acids
• CPC Class Codes: A61K 31/17 having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine isoureas, isothioureas A61K31/155; sulfonylureas A61K31/64
• CPC Class Codes: A61K 33/14 Alkali metal chlorides; Alkaline earth metal chlorides
• CPC Class Codes: A61K 8/42 Amides
• CPC Class Codes: A61K 8/46 containing sulfur A61K8/44 takes precedence
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 3/00 Manicure or pedicure preparations

Abstract

The use of urea and/or ethanol with pharmaceutical compositions containing DMSO is disclosed. The result is a reduction in the undesirable side-effects normally associated with the application of DMSO compositions, enhancement of the desired physiological effects produced by DMSO compositions, and other benefits. Specific compositions contain DMSO with urea and/or alcohol and may also contain NaCl, KCl and/or acetamide.

The use of DMSO to reduce the mortality rate of fish treated by hyperosmotic delivery is also disclosed.

Claims

1. In a method for administrating dimethyl sulfoxide to a host, the improvement comprising reducing the side effects of malodorous breath and skin reactions normally associated with such dimethyl sulfoxide administration, comprising the step of:

administrating to said host a composition comprising dimethyl sulfoxide and a side-effect reducing agent taken from the group consisting of urea, or ethanol or mixtures thereof in an amount which is effective for said purpose.

2. A method according to claim 1 wherein said composition further includes acetamide.

3. The method according to claim 1 wherein said composition further includes sodium chloride.

4. The method according to claim 1 wherein said composition further includes potassium chloride.

5. The method according to claim 1 wherein said composition further includes water.

6. The method according to claim 1 wherein the weight ratio of urea to dimethyl sulfoxide is greater than 1:

99.

7. The method according to claim 1 wherein the ratio of urea to dimethyl sulfoxide is greater than 1:

9.

8. The method according to claim 1 wherein said composition has the following formulation:

space="preserve" listing-type="tabular">______________________________________ dimethyl sulfoxide about 19 grams;

urea about 9 grams;

sodium chloride about 1 gram; and

water at least about 6 grams;

______________________________________

whereby the aforementioned composition formulation is provided with the weight ratios noted.