Methylsulfonylmethane and methods of use

• US 4,296,130 A
• Filed: 08/30/1979
• Issued: 10/20/1981
• Est. Priority Date: 08/30/1979
• Status: Expired due to Term

• Current Assignee: Cardinal Associates, Inc. (Balchem Corporation)
• Original Assignee: Robert J. Herschler
• Inventors: Herschler, Robert J.
• Primary Examiner(s): Friedman, Stanley J.
• Application Number:
  US06/071,068
• Time in Patent Office: 782 Days
• Field of Search: 424/337
• US Class Current: 514/711
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/75 Anti-irritant
• CPC Class Codes: A61K 31/10 Sulfides; Sulfoxides; Sulfones
• CPC Class Codes: A61K 31/17 having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine isoureas, isothioureas A61K31/155; sulfonylureas A61K31/64
• CPC Class Codes: A61K 31/7004 Monosaccharides having only carbon, hydrogen and oxygen atoms
• CPC Class Codes: A61K 33/14 Alkali metal chlorides; Alkaline earth metal chlorides
• CPC Class Codes: A61K 8/46 containing sulfur A61K8/44 takes precedence
• CPC Class Codes: A61P 7/08 Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock artificial tears A61P27/04
• CPC Class Codes: A61Q 17/02 containing insect repellants
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 3/00 Manicure or pedicure preparations
• CPC Class Codes: A61Q 3/02 Nail coatings
• CPC Class Codes: A61Q 5/006 Antidandruff preparations
• CPC Class Codes: A61Q 5/02 Preparations for cleaning the hair
• CPC Class Codes: A61Q 5/06 Preparations for styling the hair, e.g. by temporary shaping or colouring

Abstract

Preparations containing methylsulfonylmethane (MSM) for administration to the skin, nails, other tissue and/or body fluids of a human or other animal subject are disclosed. Such compositions soften skin, strengthen nails and provide other benefits when applied topically. And, MSM compositions may also be administered orally, by injection and by inhalation.

In many instances, the effectiveness of MSM compositions is enhanced when such compositions contain carbamide (urea). Also, carbamide compositions are stabilized when they contain the MSM.

For topical administration, MSM compositions may be formulated in creams, lotions or gels which may be used alone or to serve as stable, neutral vehicles for other skin conditioning substances or therapeutically active drugs. Aqueous MSM solutions are suitable blood diluents.

Claims

1. A method of extending the blood supply of a warm blooded animal which method comprises:

intravenously introducing into the blood of said warm blooded animal requiring such treatment a blood diluent comprising an aqueous solution of methylsulfonylmethane, present in an amount of about 0.1-50 weight percent.

2. A method for softening the skin and nails of warm blooded animals, which method comprises:

topically applying to the skin or nails of said warm blooded animal requiring such treatment an effective amount of a composition consisting essentially of methylsulfonylmethane.